CAS 1968-05-4

3,3'-Diindolilmetano

Descrição:

3,3'-Diindolilmetano (DIM) é um composto orgânico derivado do indol, formado especificamente através da dimerização do indol-3-carbinol, que é encontrado em vegetais crucíferos como brócolis e couve de Bruxelas. É caracterizado por seus dois anéis de indol conectados por uma ponte de metileno. O DIM é conhecido por seus potenciais benefícios à saúde, particularmente no contexto da prevenção do câncer e do equilíbrio hormonal, pois pode influenciar o metabolismo do estrogênio e exibir propriedades anti-inflamatórias. O composto é tipicamente um sólido cristalino amarelo a laranja e é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Sua fórmula molecular é C18H16N2, e possui um peso molecular relativamente baixo. O DIM despertou interesse na pesquisa nutricional e farmacêutica devido às suas propriedades bioativas, e estudos exploraram seu papel na modulação de várias vias biológicas, incluindo apoptose e regulação do ciclo celular. No entanto, mais pesquisas são necessárias para entender completamente seus mecanismos e potencial terapêutico.

Fórmula: C₁₇H₁₄N₂

InChI: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

Chave InChI: InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N

SMILES: C(C=1C=2C(NC1)=CC=CC2)C=3C=4C(NC3)=CC=CC4

Sinónimos:

• 1H-Indole, 3,3′-methylenebis-
• 3,3'-Methylenebisindole
• 3,3'-methanediylbis(1H-indole)
• 3,3'Diindolemethane
• 3,3-Methylenediindole
• 3,3′-Bisindolylmethane
• 3,3′-Methanediyldi(1H-indole)
• 3,3′-Methylenebis[1H-indole]
• 3-[(1H-Indol-3-yl)methyl]-1H-indole
• Arundine
• Bis(1H-indol-3-yl)methane
• Bis(3-indolyl)methane
• Cervicon-DIM
• DIM
• DIM (AhR agonist)
• DIM (diindolylmethane)
• Di(1H-indol-3-yl)methane
• Diindolylmethane
• Diindoylmethane
• Hb 236
• Indole, 3,3′-methylenedi-
• Infemin
• 3,3-Diindolylmethane

3,3'-Methylenediindole

CAS: 1968-05-4

Fórmula: C₁₇H₁₄N₂

Pureza: >98.0%(N)

Cor e Forma: White to Light yellow to Light red powder to crystal

Peso molecular: 246.31

Ref: 3B-M1399

3,3'-Bisindolylmethane

CAS: 1968-05-4

Fórmula: C₁₇H₁₄N₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 246.3065

Ref: IN-DA003BAM

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.

Fórmula: C₁₇H₁₄N₂

Pureza: 99.09%

Cor e Forma: Solid

Peso molecular: 246.31

Ref: TM-T2991

3,3''-Diindolylmethane

CAS: 1968-05-4

Fórmula: C₁₇H₁₄N₂

Pureza: ≥ 98.0% (anhydrous basis)

Cor e Forma: White to off-white crystalline powder

Peso molecular: 246.31

Ref: 7W-GK6642

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane

Pureza: ≥98%

Peso molecular: 246.31g/mol

Ref: 54-BUP14951

3,3-MethylenedIIndole

CAS: 1968-05-4

3,3-MethylenedIIndole

Pureza: 98%

Peso molecular: 246.31g/mol

Ref: 54-OR1010762

3,3'-Diindolylmethane

CAS: 1968-05-4

Fórmula: C₁₇H₁₄N₂

Cor e Forma: Neat

Peso molecular: 246.31

Ref: 04-C12635850

3,3'-Diindolylmethane

Produto Controlado

CAS: 1968-05-4

Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),

Fórmula: C₁₇H₁₄N₂

Cor e Forma: Neat

Peso molecular: 246.31

Ref: TR-D455190

Bis (3-indolyl)methane

CAS: 1968-05-4

Fórmula: C₁₇H₁₄N₂

Pureza: 98%

Cor e Forma: Solid, White to pale reddish yellow powder

Peso molecular: 246.313

Ref: 10-F024220

3,3'-Diindolymethane (synthetic)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries.
It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Fórmula: C₁₇H₁₄N₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 246.31 g/mol

Ref: 3D-FD14886

3,3'-Diindolymethane (natural)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries.
It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Fórmula: C₁₇H₁₄N₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 246.31 g/mol

Ref: 3D-FD14887