CAS 19774-82-4

Cloridrato de amiodarona

Descrição:

Cloridrato de amiodarona é um medicamento antiarrítmico sintético usado principalmente para tratar vários tipos de arritmias cardíacas, particularmente taquicardia ventricular e fibrilação atrial. É classificado como um agente antiarrítmico de Classe III, o que significa que atua prolongando a duração do potencial de ação e o período refratário no tecido miocárdico. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-a adequada para administração intravenosa. Sua estrutura química inclui um moiety de benzofurano, que contribui para suas propriedades farmacológicas. Cloridrato de amiodarona exibe uma longa meia-vida, permitindo efeitos terapêuticos sustentados, mas também pode levar a potenciais efeitos colaterais, incluindo disfunção da tireoide, toxicidade pulmonar e alterações na pele. Devido à sua farmacocinética complexa, o monitoramento cuidadoso dos pacientes é essencial durante o tratamento. O número CAS 19774-82-4 identifica exclusivamente este composto em bancos de dados químicos, facilitando a pesquisa e os processos regulatórios.

Fórmula: C₂₅H₂₉I₂NO₃·ClH

InChI: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

Chave InChI: InChIKey=ITPDYQOUSLNIHG-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl

Sinónimos:

• 2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
• Amiodar
• Amiodarone hydrochlorde
• Amiodarone hydrochloride
• Amiodaronum hydrochloride
• Ancoron
• Angiodarona
• Atlansil
• Cordarex
• Cordarone
• Cordarone X
• Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl, hydrochloride
• L 3428
• L 3428-Labaz
• Methanone, (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-, hydrochloride
• Methanone, (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-, hydrochloride (1:1)
• Miocard
• Miodaron
• Nexterone
• Ortacrone
• Pacerone
• Ritmocardyl
• Rythmarone
• Skf 33134A

Amiodarone Hydrochloride

CAS: 19774-82-4

Fórmula: C₂₅H₃₀ClI₂NO₃

Peso molecular: 681.8

Ref: BE-MU-5331

Amiodarone hydrochloride

CAS: 19774-82-4

Fórmula: C₂₅H₃₀ClI₂NO₃

Peso molecular: 681.8

Ref: BE-RMCA179001

(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone hydrochloride

CAS: 19774-82-4

Pureza: 97%

Peso molecular: 681.7800293

Ref: 10-F869167

Amiodarone hydrochloride (Standard)

CAS: 19774-82-4

Amiodarone hydrochloride (Standard) is a reference standard for research and analysis in studies involving Amiodarone hydrochloride. Amiodarone hydrochloride is an anti-anginal agent and a class III antiarrhythmic drug that inhibits potassium channels (including wild-type hERG channels and their tail currents, with an IC₅₀ of approximately 45 nM) as well as voltage-gated sodium channels. This leads to prolonged action potential duration in ventricular and atrial myocytes, resulting in reduced heart rate and vascular resistance. It activates ERK1/2 and p38 MAPK signaling pathways in fibroblasts, promoting cell proliferation and myofibroblast differentiation. Amiodarone hydrochloride is widely used in the study of supraventricular and ventricular arrhythmias and can also be used to establish pulmonary fibrosis animal models.

Fórmula: C₂₅H₃₀ClI₂NO₃

Peso molecular: 681.773

Ref: TM-TMSM-3338

Amiodarone HCl - Bio-X ™

CAS: 19774-82-4

Amiodarone, a class III anti-arrhythmic agent is used to treat and prevent certain types of irregular heartbeats. It is a competitor for natural ligands of alpha and beta adrenergic receptors, muscarinic acetylcholine receptors, histamine H1 receptors, and serotonin 5HT2A/5HT2C receptors. Amiodarone has been shown to reduce the number of atrial and ventricular arrhythmias in patients with structural heart disease, and has been used to treat atrial fibrillation, ventricular tachycardia, and Wolff-Parkinson-White Syndrome. It has also been used in the prevention of myocardial infarcts due to its ability to modify blood pressure and maintain cardiac function. In addition, amiodarone inhibits prostaglandin synthesis by inhibiting cyclooxygenase enzymes. This prevents inflammation in the gastrointestinal tract and reduces bowel disease symptoms such as cramping or diarrhoea. Amiodarone HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₅H₂₉I₂NO₃•HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 681.77 g/mol

Ref: 3D-BA139263