CAS 2031177-48-5

Fórmula: C23H17F3N4O2S2

InChI: InChI=1S/C23H17F3N4O2S2/c24-23(25,26)14-3-1-13(2-4-14)21(32)30-22-29-18-10-7-16(11-19(18)34-22)28-20(31)12-33-17-8-5-15(27)6-9-17/h1-11H,12,27H2,(H,28,31)(H,29,30,32)

Chave InChI: XPPKZMFJCSEUSX-UHFFFAOYSA-N

SMILES: C1=CC(=CC=C1C(=O)NC2=NC3=C(S2)C=C(C=C3)NC(=O)CSC4=CC=C(C=C4)N)C(F)(F)F

ZM223

CAS: 2031177-48-5

Ref: IN-DA01V3N1

ZM223

CAS: 2031177-48-5

ZM223

Fórmula: C₂₃H₁₇F₃N₄O₂S₂

Pureza: ≥98%

Peso molecular: 502.53

Ref: 54-BUP04561

ZM223

CAS: 2031177-48-5

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

Fórmula: C₂₃H₁₇F₃N₄O₂S₂

Pureza: 99.73%

Cor e Forma: Solid

Peso molecular: 502.53

Ref: TM-T13412

ZM223

CAS: 2031177-48-5

ZM223 is a potent and selective covalent inhibitor of ubiquitin ligases. It has shown potent antitumor activity in various animal tumor models, including pleural mesothelioma, and inhibits the growth of cancer cells. ZM223 inhibits the activation of signal proteins by ubiquitin ligases and prevents the formation of new protein complexes. ZM223 also has anticancer activities that are independent of its inhibitory effects on ubiquitin ligases. These anticancer activities may be due to its ability to inhibit cellular proliferation and promote apoptosis in cancer cells.

Fórmula: C₂₃H₁₇F₃N₄O₂S₂

Pureza: Min. 95%

Peso molecular: 502.5 g/mol

Ref: 3D-GGD17748