CAS 203120-17-6
:Laninamivir
Descrição:
Laninamivir é um composto antiviral usado principalmente no tratamento da influenza. Pertence à classe dos inibidores da neuraminidase, que funcionam bloqueando a enzima viral neuraminidase, impedindo assim a liberação de novas partículas virais das células infectadas e limitando a propagação do vírus nas vias respiratórias. Laninamivir é caracterizado por sua longa meia-vida, permitindo uma dosagem menos frequente em comparação com outros medicamentos antivirais. É tipicamente administrado por inalação, o que facilita a entrega direta ao local da infecção nos pulmões. O composto mostrou eficácia contra várias cepas de influenza, incluindo aquelas resistentes a outros agentes antivirais. Além disso, Laninamivir tem um perfil de segurança favorável, com efeitos colaterais comuns sendo leves e transitórios. Suas propriedades farmacocinéticas únicas e mecanismo de ação o tornam uma opção valiosa no manejo da influenza, particularmente em populações de alto risco para complicações do vírus.
Fórmula:C13H22N4O7
InChI:InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1
Chave InChI:InChIKey=QNRRHYPPQFELSF-CNYIRLTGSA-N
SMILES:[C@H]([C@@H](CO)O)(OC)[C@]1([C@H](NC(C)=O)[C@@H](NC(=N)N)C=C(C(O)=O)O1)[H]
Sinónimos:- (4S,5R,6R)-5-Acetamido-4-carbamimidamido-6-((1R,2R)-3-hydroxy-2-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
- (4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
- 203120-17-6
- 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-<span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-non-2-enonic acid
- <span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
- Laninamivir
- R 125489
- D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
- 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid
Ordenar por
Pureza (%)
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100
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0
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50
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90
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95
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100
9 produtos.
D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
CAS:Fórmula:C13H22N4O7Pureza:98%Cor e Forma:SolidPeso molecular:346.3364Laninamivir
CAS:<p>Laninamivir (R 125489) inhibits influenza NA (IC50: 0.90-3.12 nM) across strains H12N5, pH1N1, and H2N2.</p>Fórmula:C13H22N4O7Pureza:99%Cor e Forma:SolidPeso molecular:346.34(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid
CAS:(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic AcidPureza:98%Peso molecular:346.34g/molLaninamivir
CAS:<p>Applications A new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.<br>References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),<br></p>Fórmula:C13H22N4O7Cor e Forma:White To Off-WhitePeso molecular:346.34(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-4-guanidino-3,4-dihydro-2H-pyran-6-carboxylic acid
CAS:Fórmula:C13H22N4O7Pureza:98%Peso molecular:346.34Laninamivir-13C,15N2
CAS:Produto Controlado<p>Applications Isotope labelled Laninamir (L174000) is a new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.<br>References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),<br></p>Fórmula:C13H22N4O7Cor e Forma:NeatPeso molecular:346.34Laninamivir
CAS:<p>Laninamivir is an antiviral drug that inhibits the neuraminidase activity of influenza A and B viruses. It is a prodrug that is activated by esterases to form the active metabolite laninamivir carboxylate, which inhibits virus replication. Laninamivir has been shown to be effective against oseltamivir-resistant mutants and has been used in combination with oseltamivir as a treatment for pandemic influenza. Laninamivir has also been studied in pediatric patients with influenza-like symptoms, with significant reductions in symptom severity, duration of symptoms, and viral load.</p>Fórmula:C13H22N4O7Pureza:Min. 95%Cor e Forma:PowderPeso molecular:346.34 g/mol
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