CAS 206361-99-1

Darunavir

Descrição:

Darunavir é um medicamento antirretroviral utilizado principalmente no tratamento do HIV/AIDS. Pertence à classe de medicamentos conhecidos como inibidores da protease, que atuam inibindo a enzima protease, crucial para o processo de replicação viral. Darunavir é caracterizado por sua alta potência contra cepas de HIV, incluindo aquelas resistentes a outros inibidores da protease. A fórmula química de Darunavir é C27H37N3O4S, e apresenta um grupo sulfonamida, que contribui para sua atividade antiviral. A substância é tipicamente administrada em combinação com outros agentes antirretrovirais para aumentar a eficácia e reduzir o risco de resistência. Darunavir é conhecido por seu perfil farmacocinético favorável, permitindo a dosagem uma vez ao dia em muitos casos. Geralmente é bem tolerado, embora possa causar efeitos colaterais como distúrbios gastrointestinais e possíveis elevações das enzimas hepáticas. Assim como em todas as terapias antirretrovirais, o monitoramento de interações medicamentosas e a adesão aos regimes de tratamento são essenciais para resultados ótimos no manejo do HIV.

Fórmula: C₂₇H₃₇N₃O₇S

InChI: InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

Chave InChI: InChIKey=CJBJHOAVZSMMDJ-HEXNFIEUSA-N

SMILES: O(C(N[C@H]([C@@H](CN(S(=O)(=O)C1=CC=C(N)C=C1)CC(C)C)O)CC2=CC=CC=C2)=O)[C@@H]3[C@]4([C@@](OC3)(OCC4)[H])[H]

Sinónimos:

• (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
• (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
• Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, hexahydrofuro[2,3-b]furan-3-yl ester, [3R-[3α(1S*,2R*),3aβ,6aβ]]-
• Darunavir & its intermediates
• Darunavir & its intermediates (R&D)
• Prezista
• TMC 114 (inhibitor)
• Tmc 114
• Tmc 41629
• Uic 94017

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Cor e Forma: White To Off-White Solid

Peso molecular: 547.67

Ref: 4Z-D-371

Darunavir

CAS: 206361-99-1

Darunavir

Pureza: ≥98%

Peso molecular: 547.66g/mol

Ref: 54-BUP13325

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder or solid

Peso molecular: 547.66

Ref: 7W-GP5767

Darunavir

CAS: 206361-99-1

Darunavir

Pureza: 98%

Peso molecular: 547.66g/mol

Ref: 54-OR1027115

Darunavir

Produto Controlado

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Cor e Forma: Neat

Peso molecular: 547.66

Ref: 04-C11965000

Darunavir

CAS: 206361-99-1

Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS.

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: 99.67% - 99.76%

Cor e Forma: White Amorphous Solid

Peso molecular: 547.66

Ref: TM-T2324

Darunavir

CAS: 206361-99-1

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Fórmula: C₂₇H₃₇N₃O₇S

Cor e Forma: Beige

Peso molecular: 547.66

Ref: TR-D193500

Darunavir

CAS: 206361-99-1

Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 547.66 g/mol

Ref: 3D-FH20801

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: 98%

Cor e Forma: Liquid, No data available.

Peso molecular: 547.67

Ref: 10-F547231