CAS 208255-80-5

Inibidor de γ-secretase IX

Descrição:

Inibidor de γ-secretase IX é um composto de molécula pequena conhecido por seu papel na inibição do complexo γ-secretase, que é crucial no processamento da proteína precursora de amiloide (APP) e na produção de peptídeos de amiloide-beta. Essa inibição é de particular interesse na pesquisa sobre a doença de Alzheimer, uma vez que o acúmulo de amiloide-beta está associado à neurodegeneração. O composto é caracterizado por sua capacidade de interferir seletivamente na atividade enzimática da γ-secretase, modulando assim as vias de sinalização envolvidas na proliferação e diferenciação celular. Sua estrutura química geralmente inclui grupos funcionais específicos que aumentam sua afinidade de ligação ao sítio ativo do complexo γ-secretase. Em ambientes de laboratório, Inibidor de γ-secretase IX é utilizado em vários ensaios para estudar os efeitos da inibição da γ-secretase nos processos celulares e explorar estratégias terapêuticas potenciais para doenças neurodegenerativas. Assim como muitos agentes farmacológicos, a eficácia e o perfil de segurança do composto são críticos para sua aplicação potencial em ambientes clínicos.

Fórmula: C₂₃H₂₆F₂N₂O₄

InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1

Chave InChI: InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N

SMILES: [C@@H](NC([C@@H](NC(CC1=CC(F)=CC(F)=C1)=O)C)=O)(C(OC(C)(C)C)=O)C2=CC=CC=C2

Sinónimos:

• An-37124
• DAPT (enzyme inhibitor)
• Dapt
• Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Gsi-Ix
• Ly-374973
• N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
• N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
• N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
• tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
• γ-Secretase inhibitor IX
• Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

DAPT

CAS: 208255-80-5

Fórmula: C₂₃H₂₆F₂N₂O₄

Pureza: >97.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 432.47

Ref: 3B-D4257

DAPT

CAS: 208255-80-5

A cell-permeable dipeptide that suppresses A production by blocking -secretase

Fórmula: C₂₃H₂₆F₂N₂O₄

Cor e Forma: Solid, White

Peso molecular: 432.47

Ref: 02-J65864

Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

CAS: 208255-80-5

Fórmula: C₂₃H₂₆F₂N₂O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 432.4603

Ref: IN-DA002JLH

DAPT

CAS: 208255-80-5

DAPT

Pureza: ≥98%

Peso molecular: 432.46g/mol

Ref: 54-BUP15441

DAPT

CAS: 208255-80-5

DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.

Fórmula: C₂₃H₂₆F₂N₂O₄

Pureza: 98.06% - 99.81%

Cor e Forma: White Solid

Peso molecular: 432.46

Ref: TM-T6202

DAPT

CAS: 208255-80-5

DAPT

Pureza: 98%

Peso molecular: 432.46g/mol

Ref: 54-BISN0140

DAPT

CAS: 208255-80-5

Fórmula: C₂₃H₂₆F₂N₂O₄

Pureza: (NMR) ≥ 98.0%

Cor e Forma: White to off-white solid

Peso molecular: 432.50

Ref: 7W-GK0567

DAPT

CAS: 208255-80-5

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2).
References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)

Fórmula: C₂₃H₂₆F₂N₂O₄

Cor e Forma: Off White Solid

Peso molecular: 432.46

Ref: TR-D193290

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid. It has been shown to prevent the formation of plaques in the brain and may be used to treat Alzheimer's disease. (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu has also been shown to inhibit the production of tumor necrosis factor alpha (TNFα), which is involved in inflammation and carcinogenesis. The drug has been shown to reduce myocardial infarct size by preventing cardiac cell death and reducing inflammation following a heart attack. It is also active against multiple types of cancer cells, including carcinoma cell lines and multidrug resistant cells.

Fórmula: C₂₃H₂₆N₂O₄F₂

Pureza: Min. 95%

Peso molecular: 432.47 g/mol

Ref: 3D-IGS-3641-PI

DAPT

CAS: 208255-80-5

Inhibitor of proteaseγ‐secretase, which allows to modulate of the activity of γ‐secretase substrates Notch, E-cadherin, ErbB4, and amyloid precursor protein (APP). The compound can inhibit the growth of tongue carcinoma cells by arresting cell cycle in G0–G1 phase, modulate the activity of Notch1 receptor and Caspase-3 protease and induce apoptosis. It was also demonstrated that this inhibitor reduces the levels of β-amyloid peptide in the brain of mice model for Alzheimer’s disease. This compound also enhances the neuronal differentiation embryonic cells.

Fórmula: C₂₃H₂₆O₄N₂F₂

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 432.46 g/mol

Ref: 3D-FT34136

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.

Fórmula: C₂₃H₂₆N₂O₄F₂

Pureza: Min. 95%

Peso molecular: 432.46 g/mol

Ref: 3D-IGS-3219-V