CAS 20830-75-5

Digoxina

Descrição:

Digoxina é um glicosídeo cardíaco derivado das folhas da planta dedaleira (Digitalis purpurea) e é utilizado principalmente no tratamento de várias condições cardíacas, particularmente fibrilação atrial e insuficiência cardíaca. Funciona inibindo a bomba de ATPase sódio-potássio, levando a um aumento nas concentrações de cálcio intracelular, o que melhora a contratilidade cardíaca. Digoxina é caracterizado por sua janela terapêutica relativamente estreita, o que significa que a diferença entre uma dose eficaz e uma dose tóxica é pequena, exigindo monitoramento cuidadoso dos níveis séricos em pacientes. Geralmente é administrado por via oral ou intravenosa e é conhecido por seus potenciais efeitos colaterais, que podem incluir distúrbios gastrointestinais, alterações visuais e arritmias. A substância tem uma fórmula molecular de C41H64O14 e um peso molecular de aproximadamente 780,94 g/mol. A farmacocinética de Digoxina é influenciada por fatores como a função renal e interações com outros medicamentos, tornando a dosagem individualizada essencial para um uso seguro e eficaz.

Fórmula: C₄₁H₆₄O₁₄

InChI: InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

Chave InChI: InChIKey=LTMHDMANZUZIPE-PUGKRICDSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinónimos:

• (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 12β-Hydroxydigitoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Cardigox
• Cardiogoxin
• Cardioxin
• Cardixin
• Cardoxin
• Chloroformic digitalin
• Coragoxine
• Cordioxil
• Davoxin
• Digacin
• Digicor
• Digitek
• Digitoxin, 12β-hydroxy-
• Digomal
• Digon
• Digosin
• Digoxin (FDA)
• Digoxin Nativelle
• Digoxina
• Digoxine
• Dilanacin
• Dixina
• Dokim
• Dynamos
• Eudigox
• Fargoxin
• Grexin
• Homolle's digitalin
• Lanacordin
• Lanacrist
• Lanicor
• Lanikor
• Lanocardin
• Lanorale
• Lanoxicaps
• Lanoxin
• Lanoxin PG
• Lenoxicaps
• Lenoxin
• Longdigox
• Mapluxin
• Natigoxin
• NeoDioxanin
• Novodigal-Amp.
• Nsc 95100
• Purgoxin
• Rougoxin
• Stillacor
• Toloxin
• Vanoxin
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin, 96%

CAS: 20830-75-5

Digoxin, 96%, Thermo Scientific Chemicals

Fórmula: C₄₁H₆₄O₁₄

Pureza: 96%

Cor e Forma: Powder, White

Peso molecular: 780.95

Ref: 02-B21902

Digoxin

CAS: 20830-75-5

Digoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₄₁H₆₄O₁₄

Pureza: (HPLC) ≥95%

Cor e Forma: Powder

Peso molecular: 780.95

Ref: 11-0830

Digoxin 1.0 mg/ml in Methanol

CAS: 20830-75-5

Cor e Forma: Single Solution

Ref: 61-AMP0212.00-01

Digoxin, 1mg/ml in Methanol

CAS: 20830-75-5

Cor e Forma: Single Solution

Ref: LP-DOX-1921-1LM

Digoxin

CAS: 20830-75-5

Cor e Forma: Neat

Ref: 61-FOR0212.00

DIGOXIN FOR PEAK IDENTIFICATION CRS

CAS: 20830-75-5

DIGOXIN FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.9385

Ref: 41-Y0000554

DIGOXIN CRS

CAS: 20830-75-5

DIGOXIN CRS

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: White. Whitish. Powder.

Peso molecular: 780.9385

Ref: 41-D1900000

DIGOXIN RS

CAS: 20830-75-5

DIGOXIN RS

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.9385

Ref: 41-ICRS0289

Digoxin

CAS: 20830-75-5

Other glycosides, natural or reproduced by synthesis, a

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: White Translucent Crystalline Powder Crystals

Peso molecular: 780.94

Ref: 45-1200000

Digoxin

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Pureza: ≥ 94.5% (anhydrous basis)

Cor e Forma: White to off-white powder

Peso molecular: 780.95

Ref: 7W-GC1807

Digoxin

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 780.95

Ref: 4Z-D-751

Digoxin, USP grade

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.95

Ref: 7W-GC1100

Digoxin

CAS: 20830-75-5

Digoxin

Pureza: 96%

Cor e Forma: White Solid

Peso molecular: 780.94g/mol

Ref: 54-BID2190

Digoxin-d3

CAS: 127299-95-0, 20830-75-5

Fórmula: C₄₁H₆₁D₃O₁₄

Cor e Forma: Off-White Solid

Peso molecular: 783.98

Ref: 4Z-D-752

Digoxin

Produto Controlado

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: Neat

Peso molecular: 780.94

Ref: 04-C12633850

Digoxin

CAS: 20830-75-5

Cor e Forma: White

Ref: LP-DOX-1921-10

Digoxin

CAS: 20830-75-5

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. Digoxin and other cardiac glycosides can inhibit hypoxia-inducible factor 1 (HIF-1)α synthesis and block tumor growth.

Fórmula: C₄₁H₆₄O₁₄

Pureza: 95%~99%

Peso molecular: 780.949

Ref: BP-BP0490

Digoxin

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Pureza: >96.0%(HPLC)

Cor e Forma: White to Almost white powder to crystaline

Peso molecular: 780.95

Ref: 3B-D1828

Digoxin

Produto Controlado

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: Neat

Peso molecular: 780.94

Ref: 86-MM0212.00

Digoxin RS

CAS: 20830-75-5

Cor e Forma: Colorless To White

Ref: 2K-1065000021

Digoxin

Produto Controlado

CAS: 20830-75-5

Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aronson, J.K., et al.: Clin. Pharmacokinet, 5,137 (1980), Foss, P.R.B., Anal. Profiles Drug Subs., 9, 207 (1980),

Fórmula: C₄₁H₆₄O₁₄

Cor e Forma: White

Peso molecular: 780.94

Ref: TR-D446575

12β-Hydroxydigitoxin

CAS: 20830-75-5

Please enquire for more information about 12beta-Hydroxydigitoxin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fórmula: C₄₁H₆₄O₁₄

Peso molecular: 780.95 g/mol

Ref: 3D-J-013666

Digoxin

CAS: 20830-75-5

Digoxin and its derivatives are the most widely used as cardiac glycosides. Digoxin is isolated from the foxglove plant, Digitalis lanata, and has pharmacokinetic properties that are intermediate between digitoxin and the short acting strophanthus glycosides. Digoxin is regarded as the drug of choice for the treatment of congestive heart failure as its main assets are the rapid onset of action, good absorption ratio and the medium half-life which makes toxic reactions easier to manage (Albrecht, 1999).

Fórmula: C₄₁H₆₄O₁₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 780.94 g/mol

Ref: 3D-OD01513

Digoxin extrapure, 95%

CAS: 20830-75-5

Fórmula: C₄₁H₆₄O₁₄

Pureza: min. 95%

Cor e Forma: White to off white, Crystalline powder, Clear

Peso molecular: 780.94

Ref: SR-48712