CAS 20830-81-3

Daunorrubicina

Descrição:

Daunorrubicina é um antibiótico antraciclínico que é usado principalmente na quimioterapia do câncer, particularmente para tratar certos tipos de leucemia, como leucemia mieloide aguda (LMA) e leucemia linfoblástica aguda (LLA). É derivado da bactéria Streptomyces peucetius e funciona intercalando-se no DNA, inibindo assim a síntese de DNA e RNA, o que leva à morte celular. Daunorrubicina é caracterizado por sua cor vermelha, que é indicativa de sua estrutura antraciclínica. O composto possui uma estrutura molecular complexa que inclui um sistema de anel tetracíclico, que é essencial para sua atividade biológica. Geralmente é administrado por via intravenosa e pode apresentar efeitos colaterais como cardiotoxicidade, mielossupressão e náuseas. Devido aos seus efeitos potentes, Daunorrubicina é frequentemente usado em combinação com outros agentes quimioterápicos para aumentar a eficácia terapêutica enquanto gerencia a resistência potencial. Seu uso é cuidadosamente monitorado e a dosagem é ajustada com base na resposta e tolerância do paciente.

Fórmula: C₂₇H₂₉NO₁₀

InChI: InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1

Chave InChI: InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

Sinónimos:

• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,l 1-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• (7S,9S)-9-acetyl-6,9,11-trihydroxy-4-methoxy-7-tetrahydropyran-2-yloxy-8,10-dihydro-7H-tetracene-5,12-dione
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• (8S-Cis)-8-Acetyl-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-5,12-Naphthacenedione Hydrochloride
• (8S-Cis)-8-Acetyl-10-[(3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyrannosyl)Oxy]
• (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• 3-Acetyl-1,2,3,4,6,11-Hexahydro-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1-Naph
• 3-Acetyl-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1,2,3,4,6,11-Hexahydrotetracen-1-Yl 3-Amino-2,3,6-Trideoxyhexopyranoside
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[3-amino,2,3,6-trideoxy-α-L-lyoxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)
• Acetyladriamycin
• Ammonia
• Cerubidin
• D-Glucose, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-
• DaunoXome
• Daunoblastina
• Daunomycin Hydrochloride
• Daunomycine
• Daunorrubicina
• Daunorubicin
• Daunorubicine
• Daunorubicine Hydrochloride
• Fsl 0507
• Hydrate
• Hydrochloride
• Leukaemomycin C
• Leukaemomycin C Hydrochloride
• Methane
• Molecular Hydrogen
• Nsc 82151
• Nsc 83142
• Rp 13057
• Rubidomycin
• Rubomycin C
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione

Daunorubicin Hydrochloride

CAS: 20830-81-3, 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·HCl

Pureza: >98.0%(N)

Cor e Forma: Orange to Red powder to crystal

Peso molecular: 563.98

Ref: 3B-D4532

Daunorubicin-13C-d3 Trifluoroacetate (Epirubicin EP Impurity D-13C-d3 Trifluoroacetate)

CAS: 20830-81-3

Fórmula: C₂₆₁₃CH₂₆D₃NO₁₀·C₂HF₃O₂

Peso molecular: 531.54 114.02

Ref: 4Z-D-4810

Daunorubicin

CAS: 20830-81-3

Daunorubicin is an anthracycline antibiotic and topoisomerase II inhibitor with anticancer activity, inhibiting DNA and RNA synthesis, leukaemia (AML)(ALL).

Fórmula: C₂₇H₂₉NO₁₀

Pureza: 97.84%

Cor e Forma: Reddish Needles

Peso molecular: 527.52

Ref: TM-T1511L

Daunorubicin

CAS: 20830-81-3

Daunorubicin

Pureza: ≥95%

Ref: 54-BUP22318

Daunorubicin-13C,d3 (>85%)

Produto Controlado

CAS: 20830-81-3

Fórmula: CC₂₆D₃H₂₆NO₁₀

Pureza: >85%

Cor e Forma: Neat

Peso molecular: 531.53

Ref: TR-D194502

Daunorubicin

CAS: 20830-81-3

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Fórmula: C₂₇H₂₉NO₁₀

Pureza: Min. 95%

Peso molecular: 527.52 g/mol

Ref: 3D-MD32002