CAS 2097136-42-8

(3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one

CAS: 2097136-42-8

(3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is an alkaloid compound, which is characterized by its complex polycyclic structure. Derived from natural sources such as plant species or synthesized through advanced organic chemistry techniques, this compound demonstrates potential through its complex pharmacodynamics. It exhibits activity by interacting with specific biological receptors, influencing signal transduction pathways, and modulating enzyme activities, thereby eliciting a variety of physiological responses.

Fórmula: C₁₈H₁₆N₂O₃

Pureza: Min. 95%

Peso molecular: 308.3 g/mol

Ref: 3D-XID13642

(S)-3'-hydroxy Blebbistatin

CAS: 2097136-42-8

(S)-3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (–)-blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S)-3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm). It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 µM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 µM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (–)-blebbistatin enantiomer in mechanism and efficacy.

Fórmula: C₁₈H₁₆N₂O₃

Cor e Forma: Solid

Peso molecular: 308.33

Ref: TM-T85155