CAS 2098-66-0

Ciproterona

Descrição:

Ciproterona é um antiandrógeno esteroidal sintético e progestágeno, utilizado principalmente no tratamento de condições relacionadas a níveis excessivos de andrógenos, como hirsutismo, acne e certos tipos de queda de cabelo em mulheres. Também é utilizado na terapia hormonal para mulheres transgênero e no manejo do câncer de próstata. Quimicamente, Ciproterona é caracterizado por sua capacidade de inibir a ação dos andrógenos bloqueando os receptores androgênicos e reduzindo a produção de testosterona. Possui uma fórmula molecular que inclui carbono, hidrogênio e oxigênio, e sua estrutura apresenta um núcleo de ciclopentanoperhidrofenantreno típico dos compostos esteroides. Ciproterona é administrado por via oral ou por injeção, e seus efeitos farmacológicos incluem propriedades antiandrogênicas, anti-inflamatórias e progestacionais. Os efeitos colaterais podem incluir ganho de peso, alterações de humor e potenciais impactos na função hepática, necessitando monitoramento durante o tratamento. No geral, Ciproterona é um composto significativo em endocrinologia e saúde reprodutiva, demonstrando a complexa interação de hormônios na fisiologia humana.

Fórmula: C₂₂H₂₇ClO₃

InChI: InChI=1/C22H27ClO3/c1-11(24)22(26)7-5-14-12-9-18(23)17-10-19(25)13-8-16(13)21(17,3)15(12)4-6-20(14,22)2/h9-10,12-16,26H,4-8H2,1-3H3/t12?,13-,14?,15?,16?,20+,21+,22+/m1/s1

Chave InChI: InChIKey=DUSHUSLJJMDGTE-ZJPMUUANSA-N

SMILES: C[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@]5(C(C)=O)O)[H])[H])[H])[H])[H]

Sinónimos:

• (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8bS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3′H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 1,2α-Methylene-6-chloro-⁶-17α-hydroxyprogesterone
• 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1β,2β-dihydro-17-hydroxy-
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron [German]
• 6-Chloro-1,2α-methylene-4,6-pregnadien-17α-ol-3,20-dione
• 6-Chloro-17-hydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione
• 6-Chloro-6-dehydro-17α-hydroxy-1,2α-methyleneprogesterone
• Bay 94-8367
• Bay94-8367
• Ciproterona
• Ciproterona [INN-Spanish]
• Ciproterone
• Ciproterone [DCIT]
• Cyproteron
• Cyproterone [INN:BAN]
• Cyproteronum
• Cyproteronum [INN-Latin]
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-
• Sh 80881
• Sh 881
• Unii-E61Q31Ek2F
• Cyproterone
• Cyproterone USP/EP/BP
• 6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione
• Cyproterone Acetate IMpurity F (Cyproterone)
• Cyproterone Acetate EP Impurity F
• Cyproterone Acetate 427-51-0 /Base
• 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chloro-1β,2β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• Cyproterone Acetate Impurity 6（Cyproterone Acetate EP Impurity F）
• Cyproterone Acetate Impurity F
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4
• Cyproterone-d5
• 1,2α-Methylene-6-chloro-6-17α-hydroxyprogesterone
• ro-17-hydroxy-
• 3’h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione,6-chloro-1-beta,2-beta-dihyd
• Cyproterone Acetate EP Impurity F (Cyproterone)

Cyproterone Acetate EP Impurity F-d3 (Cyproterone-d3)

CAS: 2098-66-0

Fórmula: C₂₂H₂₄D₃ClO₃

Peso molecular: 377.92

Ref: 4Z-C-2819

Cyproterone Acetate EP Impurity F (Cyproterone)

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Cor e Forma: Pale Yellow Solid

Peso molecular: 374.91

Ref: 4Z-C-281

Cyproterone Acetate EP Impurity D

CAS: 2098-66-0

Fórmula: C₂₄H₃₁ClO₅

Cor e Forma: Pale Yellow Solid

Peso molecular: 434.96

Ref: 4Z-C-2817

Cyproterone

Produto Controlado

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Cor e Forma: Neat

Peso molecular: 374.90

Ref: 04-C11917000

Cyproterone-d5

CAS: 2098-66-0

Fórmula: C₂₂H₂₂D₅ClO₃

Peso molecular: 379.94

Ref: 4Z-C-282

Cyproterone-d4

Produto Controlado

CAS: 2098-66-0

Applications Labelled Cyproterone (C989090). An antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Fórmula: C₂₂H₂₃D₄ClO₃

Cor e Forma: Neat

Peso molecular: 378.93

Ref: TR-C989092

Cyproterone

Produto Controlado

CAS: 2098-66-0

Impurity Cyproterone Acetate EP Impurity F
Applications Cyproterone (Cyproterone Acetate EP Impurity F) is an antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Fórmula: C₂₂H₂₇ClO₃

Cor e Forma: Off White Solid

Peso molecular: 374.90

Ref: TR-C989090

Cyproterone

Produto Controlado

CAS: 2098-66-0

Cyproterone is a steroidal anti-androgen that is used in the treatment of prostate cancer and other diseases. Cyproterone acetate (CPA) is an ester prodrug of cyproterone, which has been used as a contraceptive for more than 25 years. It binds to cytoplasmic receptors, blocking the effects of androgens on these receptors. CPA also inhibits transcriptional regulation by reducing the basal level of androgen receptor expression in target tissues. Cyproterone acetate has been shown to inhibit the growth of breast cancer cells through its ability to bind to and activate growth factor-β1 (GF-β1). CPA also has been shown to have positive effects on energy metabolism by regulating the activity of enzymes in this process. Cyproterone acetate is not active against many Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).

Fórmula: C₂₂H₂₇ClO₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 374.9 g/mol

Ref: 3D-FC20763

Cyproterone-13C2,d8

Produto Controlado

CAS: 2098-66-0

Fórmula: C₂C₂₀D₈H₁₉ClO₃

Cor e Forma: Neat

Peso molecular: 384.936

Ref: TR-C989093

Cyproterone Acetate EP Impurity F

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Peso molecular: 374.9

Ref: ST-EA-CP-C148017

Cyproterone

CAS: 2098-66-0

Cyproterone, an anti-androgen, treats female hirsutism and acne, and is used palliatively in prostate cancer.

Fórmula: C₂₂H₂₇ClO₃

Cor e Forma: Solid

Peso molecular: 374.9

Ref: TM-T21016