CAS 2140-61-6

5-Metilcitidina

Descrição:

5-Metilcitidina é um derivado de nucleosídeo da citidina, caracterizado pela presença de um grupo metila na posição 5 do anel de pirimidina. Essa modificação desempenha um papel significativo em vários processos biológicos, particularmente na regulação da expressão gênica e na estabilidade do RNA. É comumente encontrado em moléculas de RNA, especialmente em tRNA e rRNA, onde contribui para a integridade estrutural e função dessas biomoléculas essenciais. A presença do grupo metila pode influenciar a interação do RNA com proteínas e outros ácidos nucleicos, afetando assim processos celulares como tradução e transcrição. 5-Metilcitidina também está envolvido na regulação epigenética, pois pode ser um marcador para padrões de metilação do DNA. Em termos de propriedades físicas, é tipicamente um sólido cristalino branco a off-white, solúvel em água e exibe estabilidade em condições fisiológicas. Sua fórmula química é C₈H₁₁N₃O₅, e é utilizado em várias aplicações de bioquímica e biologia molecular, incluindo estudos sobre modificações de RNA e epigenética.

Fórmula: C₁₀H₁₅N₃O₅

InChI: InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1

Chave InChI: InChIKey=ZAYHVCMSTBRABG-JXOAFFINSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C(C)=C2

Sinónimos:

• 4-amino-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one
• Cytidine, 5-methyl-
• Nsc 363933
• 5-Methylcytidine
• 3: PN: US20060035254 PAGE: 63 claimed sequence

5-Methylcytidine

CAS: 2140-61-6

Fórmula: C₁₀H₁₅N₃O₅

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 257.25

Ref: 3B-M1931

5-Methylcytidine

CAS: 2140-61-6

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 257.2432

Ref: IN-DA0034AT

5-Methylcytidine

CAS: 2140-61-6

Fórmula: C₁₀H₁₅N₃O₅

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to almost white powder

Peso molecular: 257.24

Ref: 7W-GE4109

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Pureza: ≥95%

Peso molecular: 257.24g/mol

Ref: 54-BUP14699

Cytarabine EP Impurity G

CAS: 2140-61-6

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.25

Ref: 4Z-C-150030

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Pureza: 98%

Peso molecular: 257.25g/mol

Ref: 54-OR72458

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms.

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 99.02% - 99.88%

Cor e Forma: Solid

Peso molecular: 257.24

Ref: TM-T5912

5-Methylcytidine

CAS: 2140-61-6

M02111 - 5-Methylcytidine

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 97%

Cor e Forma: Solid, White - Very pale yellow powder

Peso molecular: 257.246

Ref: 10-M02111

5-Methylcytidine

Produto Controlado

CAS: 2140-61-6

Stability Hygroscopic
Applications 5-Methylcytidine is a derivative of Cytidine (C998300), found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling.
References Kammerer, B., et al.: Anal. Biol. Chem., 382, 1017 (2005); Strong, L. and Matsunaga, H.: J. Surg. Oncol., 4, 528 (1972)

Fórmula: C₁₀H₁₅N₃O₅

Cor e Forma: Neat

Peso molecular: 257.24

Ref: TR-M294850

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to 5-methylcytosine. This reaction is essential for DNA replication and repair. 5-Methylcytidine has been shown to be an important factor in the regulation of mitochondrial functions, as well as other cellular processes such as protein synthesis, nuclear DNA replication, and tumor suppression. It also has been shown to inhibit the replication of murine sarcoma virus and Toll-like receptor. 5-Methylcytidine can be used in chemotherapy treatment against mouse tumors and murine sarcoma virus by preventing viral RNA synthesis with monoclonal antibodies.

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.24 g/mol

Ref: 3D-W-201877

Cytarabine EP Impurity G

CAS: 2140-61-6

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.2

Ref: ST-EA-CP-C163007

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a nucleoside that is found in DNA and RNA. It is used in structural biology to probe the structure of DNA. 5-Methylcytidine binds to the enzyme methyl transferase, which catalyzes the transfer of a methyl group from S-adenosylmethionine to produce 5-methyluridine. This reaction occurs in long-term toxicity studies using primary cells, such as lymphocytes and fibroblasts. 5-Methylcytidine has been shown to inhibit tumour growth in mice by binding to nuclear dna polymerase and blocking transcription. The binding site for this drug on the polymerase is located at the same site as that for nucleoside analogues like azidothymidine (AZT) and zidovudine (AZT).

Fórmula: C₁₀H₁₅N₃O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 257.24 g/mol

Ref: 3D-NM03720