CAS 2140-71-8

2'-O-Metilguanosina

Descrição:

2'-O-Metilguanosina é um nucleosídeo modificado que desempenha um papel significativo em vários processos biológicos, particularmente no metabolismo do RNA. Consiste em uma base de guanina ligada a um açúcar ribose, que é ainda metilada no grupo hidroxila 2′. Essa modificação é comumente encontrada em tRNA e rRNA, contribuindo para a estabilidade e funcionalidade dessas moléculas. A presença do grupo metila melhora a integridade estrutural do RNA, influenciando seu dobramento e interação com proteínas. 2'-O-Metilguanosina também está envolvido na regulação da expressão gênica e pode afetar o splicing e a tradução do RNA. Sua fórmula química reflete a presença de átomos de carbono, hidrogênio, nitrogênio e oxigênio, característicos dos nucleosídeos. O composto é solúvel em água e exibe propriedades típicas dos nucleosídeos, como formar ligações de hidrogênio e participar do emparelhamento de bases. Devido à sua importância biológica, 2'-O-Metilguanosina é de interesse na pesquisa relacionada à biologia do RNA, terapias e ao desenvolvimento de medicamentos baseados em RNA.

Fórmula: C₁₁H₁₅N₅O₅

InChI: InChI=1/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

Chave InChI: InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N

SMILES: O(C)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](CO)[C@H]1O

Sinónimos:

• 1-Methylguanosine = 2-O-Methylguanosine
• Guanosine, 2′-O-methyl-
• 2′-O-Methylguanosine
• 2'-O-Methyl-D-guanosine

2'-O-Methylguanosine

CAS: 2140-71-8

Fórmula: C₁₁H₁₅N₅O₅

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 297.27

Ref: 3B-M2318

2'-O-Methylguanosine, 99%

CAS: 2140-71-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₁₁H₁₅N₅O₅

Pureza: 99%

Peso molecular: 297.27

Ref: 02-J65770

2'-O-Methylguanosine

CAS: 2140-71-8

Fórmula: C₁₁H₁₅N₅O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 297.2673

Ref: IN-DA00BHLE

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

CAS: 2140-71-8

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

Pureza: 98%

Peso molecular: 297.27g/mol

Ref: 54-OR1010293

2’-OMe-Guanosine

CAS: 2140-71-8

2’-OMe-Guanosine

Pureza: ≥98%

Peso molecular: 297.27g/mol

Ref: 54-BUP17632

2''-O-Methyl guanosine

CAS: 2140-71-8

Fórmula: C₁₁H₁₅N₅O₅

Pureza: ≥ 98.0%

Cor e Forma: White to almost white powder or crystals

Peso molecular: 297.27

Ref: 7W-GC3937

2'-O-Methylguanosine

CAS: 2140-71-8

Fórmula: C₁₁H₁₅N₅O₅

Peso molecular: 297.27

Ref: 4Z-G-2429

2'-OMe-Guanosine

CAS: 2140-71-8

2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.

Fórmula: C₁₁H₁₅N₅O₅

Pureza: 99.93%

Cor e Forma: White Solid

Peso molecular: 297.27

Ref: TM-T9726

2'-O-Methyl Guanosine-d3

Produto Controlado

CAS: 2140-71-8

Applications 2'-O-Methyl Guanosine-d3 is a labeled analogue of 2'-O-Methyl Guanosine (M311825), which is a Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Fórmula: C₁₁D₃H₁₂N₅O₅

Cor e Forma: Neat

Peso molecular: 300.29

Ref: TR-M311827

2'-O-Methyl Guanosine

Produto Controlado

CAS: 2140-71-8

Applications Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Fórmula: C₁₁H₁₅N₅O₅

Cor e Forma: Neat

Peso molecular: 297.27

Ref: TR-M311825

2'-O-Methylguanosine

CAS: 2140-71-8

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme's active site. 2'-O-Methylguanosine is present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. The optimum concentration for detection by analytical methods varies depending on the type of detector used.

Fórmula: C₁₁H₁₅N₅O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 297.27 g/mol

Ref: 3D-NM02941

2′-O-Methylguanosine

CAS: 2140-71-8

Fórmula: C₁₁H₁₅N₅O₅

Pureza: 98%

Cor e Forma: Solid, White to almost white powder

Peso molecular: 297.271

Ref: 10-F225192