CAS 2140-72-9

2'-O-Metilcitidina

Descrição:

2'-O-Metilcitidina é um nucleosídeo modificado que desempenha um papel significativo em vários processos biológicos, particularmente na biologia do RNA. É caracterizado pela presença de um grupo metila na posição 2′ do açúcar ribose da citidina, o que aumenta a estabilidade das moléculas de RNA e influencia suas interações com proteínas e outros ácidos nucleicos. Essa modificação é comumente encontrada na estrutura de certos tRNAs e rRNAs, contribuindo para sua integridade funcional e eficiência. A presença do grupo metila também pode afetar as propriedades de emparelhamento de bases e a conformação geral do RNA, impactando processos como tradução e regulação gênica. 2'-O-Metilcitidina é frequentemente utilizado em pesquisas e aplicações terapêuticas, incluindo o desenvolvimento de medicamentos e vacinas baseados em RNA, devido à sua capacidade de modular respostas imunológicas e melhorar as propriedades farmacocinéticas de oligonucleotídeos. Seu número CAS, 2140-72-9, é um identificador único que facilita a catalogação e o estudo deste composto na literatura científica e em bancos de dados.

Fórmula: C₁₀H₁₅N₃O₅

InChI: InChI=1/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7+,8+,9-/m1/s1

Chave InChI: InChIKey=RFCQJGFZUQFYRF-ZOQUXTDFSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Sinónimos:

• Cytidine, 2′-O-methyl-
• O2′-Methylcytidine
• 2′-O-Methylcytidine
• 4-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
• 2'-O-Methylcytidineanhydrous
• 2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM
• 2'-O-Methyl-D-cytidine

2'-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 257.25

Ref: 3B-M2317

2'-O-Methylcytidine, 99%

CAS: 2140-72-9

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 99%

Peso molecular: 257.24

Ref: 02-J65528

Cytidine, 2'-​O-​methyl-

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 257.2432

Ref: IN-DA00I44O

2''-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.24

Ref: 7W-GE9294

2’-O-Methylcytidine

CAS: 2140-72-9

2’-O-Methylcytidine

Pureza: 98%

Peso molecular: 257.24g/mol

Ref: 54-OR1010238

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine

Pureza: ≥98%

Peso molecular: 257.24g/mol

Ref: 54-BUP17963

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 99.72%

Cor e Forma: Solid

Peso molecular: 257.24

Ref: TM-T38237

2’-O-Methyl Cytidine

Produto Controlado

CAS: 2140-72-9

Applications Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Fórmula: C₁₀H₁₅N₃O₅

Cor e Forma: White

Peso molecular: 257.24

Ref: TR-M294660

2'-O-Methyl-d3 Cytidine

Produto Controlado

CAS: 2140-72-9

Applications 2’-O-Methyl-d3 Cytidine is an isotopic labeled cytidine(M294660) analog. 2’-O-Methyl Cytidine is used for the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B.

Fórmula: C₁₀H₁₂D₃N₃O₅

Cor e Forma: White To Off-White

Peso molecular: 260.26

Ref: TR-M294662

2'-O-Methylcytidine

CAS: 2140-72-9

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.

Fórmula: C₁₀H₁₅N₃O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 257.24 g/mol

Ref: 3D-NM06302

2′-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 95%

Cor e Forma: Solid, Crystalline Powder

Peso molecular: 257.246

Ref: 10-F219012

2'-O-Methylcytidine

CAS: 2140-72-9

Cis-2'-O-methylcytidine is a modified nucleoside that has shown antiviral and anticancer activity. It is a monophosphate analog of cytidine with high antiviral activity against HIV, HSV-1, HSV-2, EBV, and CMV. Cis-2'-O-methylcytidine also inhibits tumor growth in mice by inhibiting the synthesis of DNA. Cis-2'-O-methylcytidine has been synthesized from ribonucleosides and deoxyribonucleosides to provide high purity and quality.

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.24 g/mol

Ref: 3D-J-700064