CAS 2182-14-1

(-)-Vindolina

Descrição:

(-)-Vindolina é um alcaloide que ocorre naturalmente, extraído principalmente da planta Catharanthus roseus, comumente conhecida como a vinca de Madagascar. É caracterizado por sua estrutura complexa, que inclui uma estrutura tetracíclica e vários grupos funcionais, contribuindo para sua atividade biológica. Este composto é conhecido por seu papel na biossíntese do medicamento anticancerígeno vincristina, tornando-o significativo na química medicinal. (-)-Vindolina exibe um centro quiral, resultando em sua atividade óptica específica, que é crucial para suas propriedades farmacológicas. A substância é tipicamente um sólido cristalino branco a off-white e é solúvel em solventes orgânicos como metanol e etanol, mas menos solúvel em água. Sua fórmula molecular reflete um grau relativamente alto de complexidade, e é frequentemente estudada por seus potenciais efeitos terapêuticos, particularmente em oncologia. Além disso, as interações de (-)-Vindolina com mecanismos celulares e sua capacidade de inibir a divisão celular fazem dele um assunto de interesse na pesquisa do câncer e no desenvolvimento de medicamentos.

Fórmula: C₂₅H₃₂N₂O₆

InChI: InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21+,23+,24+,25-/m0/s1

Chave InChI: InChIKey=CXBGOBGJHGGWIE-ACSXSLCXSA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC=C(OC)C5)[H])CCN3CC=C2)[H]

Sinónimos:

• (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid methyl ester
• 1H-Indolizino[8,1-cd]carbazole, aspidospermidine-3-carboxylic acid deriv.
• Aspidospermidine-3-Carboxylicacid,4-(Acetyloxy)-6,7-Didehydro-3-Hydroxy-16-Me
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12beta,19alpha)-
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-
• Bufexamacum
• Methyl (2Beta,3Beta,4Beta,5Alpha,12Beta,19Alpha)-4-(Acetyloxy)-3-Hydroxy-16-Methoxy-1-Methyl-6,7-Didehydroaspidospermidine-3-Carboxylate
• Methyl (2Beta,3Beta,4Beta,5Alpha,19Alpha)-4-(Acetyloxy)-3-Hydroxy-16-Methoxy-1-Methyl-6,7-Didehydroaspidospermidine-3-Carboxylate
• Methyl (2Beta,3Beta,4Beta,5Xi,12Beta,19Alpha)-4-(Acetyloxy)-3-Hydroxy-16-Methoxy-1-Methyl-6,7-Didehydroaspidospermidine-3-Carboxylate
• Methyl (2Beta,4Beta,5Alpha,12Beta,19Alpha)-4-(Acetyloxy)-3-Hydroxy-16-Methoxy-1-Methyl-6,7-Didehydroaspidospermidine-3-Carboxylate
• NSC 91994
• Thoxy-1-Methyl-,Methylester,(2-Beta,3-Beta,4-Beta,5-Alpha,12-Beta,19-Alpha)
• Vindolin
• Vindoline Tartrate
• Vindoline free base
• Vindoline, (-)-

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-, methylester, (2b,3b,4b,5a,12R,19a)-

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 456.5314

Ref: IN-DA00I48E

Vindoline

CAS: 2182-14-1

Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.

Fórmula: C₂₅H₃₂N₂O₆

Pureza: 99.89%

Cor e Forma: White Or Offwhite Powder

Peso molecular: 456.53

Ref: TM-T2773

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Peso molecular: 456.54

Ref: 4Z-V-116001

Vindoline

CAS: 2182-14-1

Vindoline

Pureza: ≥98%

Peso molecular: 456.53g/mol

Ref: 54-BUP06409

Vindoline

CAS: 2182-14-1

Vindoline

Pureza: 98%

Peso molecular: 456.53g/mol

Ref: 54-OR1025615

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Pureza: >98.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 456.54

Ref: 3B-V0193

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Pureza: 95%~99%

Peso molecular: 456.539

Ref: BP-BP1443

Vindoline

CAS: 2182-14-1

Cor e Forma: Neat

Ref: 86-MM3359.01

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White powder

Peso molecular: 456.53

Ref: 7W-GP8222

Vindoline

Produto Controlado

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Cor e Forma: Neat

Peso molecular: 456.53

Ref: TR-V416500

Vindoline

Produto Controlado

CAS: 2182-14-1

Vindoline is a monoterpenoid indole alkaloid that is found in plants of the genus Vinca. It has been used to prepare samples for thin-layer chromatography, and can be detected by sephadex g-100. The reaction mechanism of vindoline is thought to be similar to other indole alkaloids, such as tryptamine, where two molecules are combined through a covalent bond between the amine group and the carbonyl group. Vindoline has been shown to inhibit polymerase chain reactions and also has a number of biological properties that could be useful in tissue culture. This natural product structure has been shown to have steric interactions with enzymes, including tyrosinase, which is involved in plant metabolism. Vindoline may also be able to inhibit plant physiology by altering photosynthesis or respiration.

Fórmula: C₂₅H₃₂N₂O₆

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 456.53 g/mol

Ref: 3D-FV10830

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Peso molecular: 456.54

Ref: ST-EA-CP-V49003

Vindoline

CAS: 2182-14-1

Fórmula: C₂₅H₃₂N₂O₆

Cor e Forma: White To Off-White Solid

Peso molecular: 456.54

Ref: 4Z-V-040012