CAS 21820-51-9

Fosfo-L-tirosina

Descrição:

Fosfo-L-tirosina é um derivado fosforilado do aminoácido tirosina, caracterizado pela adição de um grupo fosfato ao grupo hidroxila (-OH) da cadeia lateral da tirosina. Essa modificação desempenha um papel crucial na sinalização celular e na função das proteínas, particularmente no contexto de eventos de fosforilação que regulam vários processos biológicos. Fosfo-L-tirosina está frequentemente envolvido em vias de transdução de sinal, influenciando processos como crescimento celular, diferenciação e metabolismo. O composto é tipicamente solúvel em água e exibe uma natureza polar devido à presença do grupo fosfato, que aumenta sua reatividade e interação com outras biomoléculas. Sua presença em proteínas pode alterar significativamente sua atividade e interações, tornando-o um jogador chave na regulação das funções enzimáticas e respostas celulares. Fosfo-L-tirosina é comumente utilizado em pesquisas bioquímicas, particularmente em estudos relacionados à atividade da tirosina quinase e ao papel da fosforilação nos mecanismos celulares.

Fórmula: C₉H₁₂NO₆P

InChI: InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1

Chave InChI: InChIKey=DCWXELXMIBXGTH-QMMMGPOBSA-N

SMILES: O(P(=O)(O)O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1

Sinónimos:

• (2S)-2-Amino-3-(4-phosphonooxyphenyl)propanoic acid
• <span class="text-smallcaps">L</span>-Phosphotyrosine
• <span class="text-smallcaps">L</span>-Tyrosine, O-phosphono-
• <span class="text-smallcaps">L</span>-Tyrosine, dihydrogen phosphate (ester)
• <span class="text-smallcaps">L</span>-Tyrosine-O-phosphate
• H-Tyr(PO3)-OH
• N-phosphonotyrosine
• O-Phospho-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphono-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphotyrosine
• O-phosphono-L-tyrosine
• Phospho-<span class="text-smallcaps">L</span>-tyrosine
• Phosphotyrosine
• Tyrosine O-phosphate
• Tyrosine, di-H phosphate
• Tyrosine, dihydrogen phosphate (ester), <span class="text-smallcaps">L</span>-
• Tyrosine, phosphate
• L-Tyrosine, dihydrogen phosphate (ester)
• Tyrosine, dihydrogen phosphate (ester), L-

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: >97.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 261.17

Ref: 3B-P0959

H-Tyr(PO₃H₂)-OH

CAS: 21820-51-9

L-Phosphotyrosine can be used in the detection and quantification of tyrosine phosphorylation in proteins and as starting material in the synthesis of fluorescent substrates for protein tyrosine phosphatase assays. Furthermore, it has been incorporated in cyclic hexapeptides for studying intramolecular quenching of tryptophan fluorescence. L-Phosphotyrosine inhibits cellular growth by activating protein tyrosine phosphatases (Mishra and Hamburger). The phosphorylated amino acid protects TP53 wild-type cells against ionizing radiation.

Fórmula: C₉H₁₂NO₆P

Pureza: > 99%

Cor e Forma: Whitish Powder

Peso molecular: 261.17

Ref: 01-4025464

O-PHOSPHO-L-TYROSINE

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 261.1684

Ref: IN-DA003THO

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: ≥ 95.0%

Cor e Forma: White to off-white powder

Peso molecular: 261.17

Ref: 7W-GM6522

H-Tyr(H2PO3)-OH

CAS: 21820-51-9

H-Tyr(H2PO3)-OH

Pureza: 98%

Peso molecular: 261.17g/mol

Ref: 54-OR1007549

O-Phospho-L-tyrosine

CAS: 21820-51-9

Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.
References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)

Fórmula: C₉H₁₂NO₆P

Cor e Forma: Neat

Peso molecular: 261.17

Ref: TR-P365000

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 261.17

Ref: 10-F493251

O-Phospho-L-tyrosine

CAS: 21820-51-9

O-Phospho-L-tyrosine is a phosphorylated form of L-tyrosine. It is used as an immunogen in the production of monoclonal antibodies. O-Phospho-L-tyrosine has also been shown to inhibit the enzyme indole alkaloids, which are responsible for the development of oral pathogens. The dephosphorylation of O-Phospho-L-tyrosine by tyrosine phosphatases leads to its conversion back to L-tyrosine. This compound can be detected by chromatographic analysis and is commonly used in analytical methods to identify natural compounds.

Fórmula: C₉H₁₂NO₆P

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 261.17 g/mol

Ref: 3D-FP27018