CAS 22144-77-0

(-)-Citochalasin D

Descrição:

(-)-Citochalasin D é um alcaloide que ocorre naturalmente e é derivado de várias espécies de fungos, particularmente do gênero *Helminthosporium*. É conhecido por sua capacidade de inibir a polimerização da actina, que desempenha um papel crucial em vários processos celulares, incluindo divisão celular, motilidade e manutenção da forma. O composto exibe uma estrutura complexa caracterizada por um anel de lactona e múltiplos grupos funcionais, contribuindo para sua atividade biológica. Como um potente disruptor do citoesqueleto, (-)-Citochalasin D tem sido amplamente estudado por seus efeitos na morfologia e movimento celular, tornando-se uma ferramenta valiosa na pesquisa em biologia celular. É frequentemente utilizado em ambientes de laboratório para investigar a dinâmica do citoesqueleto e suas implicações em vários processos fisiológicos e patológicos. Além disso, devido às suas propriedades biológicas, (-)-Citochalasin D tem aplicações potenciais na pesquisa do câncer e no desenvolvimento terapêutico, embora seu uso seja limitado por sua toxicidade e pela necessidade de manuseio cuidadoso em contextos experimentais.

Fórmula: C₃₀H₃₇NO₆

InChI: InChI=1/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14-/t17-,18+,22-,23-,24+,25-,26+,29+,30?/m1/s1

Chave InChI: InChIKey=SDZRWUKZFQQKKV-JHADDHBZSA-N

SMILES: O(C(C)=O)[C@H]/1[C@]23[C@]([C@H](CC4=CC=CC=C4)NC2=O)([C@H](C)C(=C)[C@@H](O)[C@@]3(/C=C/C[C@H](C)C(=O)[C@](C)(O)\C=C1)[H])[H]

Sinónimos:

• (3R,3aS,4R,6R,6aS,7Z,10R,12S,13Z,15S)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione
• (7E,13E)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• (7E,13Z)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
• 1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, [3S-(3R*,3aS*,4R*,6R*,6aS*,7E,10R*,12S*,13E,15S*,15aS*)]-
• 3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
• Cytochalasin D, Zygusporium mansonii
• NSC 209835
• Zygosporin A
• [11]Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-
• cytochalasin D
• 1h-cycloundec(d)isoindole-1,11(2h)-dione,3-benzyl-3,3-alpha,4,5,6,6-alpha,9,10
• CYTOCHALASIN D(RG)
• (7S,13E,16S,18R,19E,21R)-21-(ACETYLOXY)-7,18-DIHYDROXY-16,18-DIMETHYL-10-PHENYL[11]CYTOCHALASA-6(12),13,19-TRIENE-1,17-DIONE
• cytochalasin D from zygosporium masonii
• (11)cytochalasa-6(12),13,19-triene-1,17-dione,21-(acetyloxy)-7,18-dihydroxy-16
• Nsc209835
• CYTOCHALICIND
• Cytohalasin d
• CYTOCHALACIND
• Cytochalasin D, Zygosporin A
• 1H-Cycloundecdisoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
• CYTOCHALASIN D FROM ZYGOSPORIUMMANSONII
• 7(S),18(R)-dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate
• [11]Cytochalasa-6[12],13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-
• 1h-cycloundec(d)isoindole-1,11(2h)-dione,3-benzyl-3,3-alpha4,5,6,6-alpha,9,10,
• CYTOCHALASIN D, ZYGOSPORIUM MANSONII
• ,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-,15-acetate
• Lygosporin a
• ,18-dimethyl-10-phenyl-,(7s,13e,16s,18r,19e,21r)-
• 1H-Cycloundec[D]isoindole-1,11(2H)-dione, 3-benzyl-3,3-.alpha.,4,5,6,6-.alpha.,9,10,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-, 15-acetate
• 7,18-dihydroxy-10-phenyl-5,16,18-trimethyl-[11]cytochalas-21-acetoxy-6(12),13,
• 15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-115-acetate
• InSolution? Cytochalasin D,

Cytochalasin D

CAS: 22144-77-0

Cytochalasin D

Fórmula: C₃₀H₃₇NO₆

Pureza: By hplc: 99.79% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 507.61787g/mol

Ref: 54-BIC1016

Cytochalasin D

CAS: 22144-77-0

Fórmula: C₃₀H₃₇NO₆

Pureza: ≥ 97.0%

Cor e Forma: White powder

Peso molecular: 507.62

Ref: 7W-GA1531

Cytochalasin D

CAS: 22144-77-0

Cytochalasin D inhibits actin, chondrogenesis, fertilization, tumor growth, and phagocytosis; may increase B16 melanoma metastasis.

Fórmula: C₃₀H₃₇NO₆

Pureza: 99.586%

Cor e Forma: Needles From Acetone-Petroleum Ether Physical Description Needles Or Fluffy White Powder (Ntp 1992)

Peso molecular: 507.62

Ref: TM-T3229

Cytochalasin D

CAS: 22144-77-0

Fórmula: C₃₀H₃₇NO₆

Pureza: 95%~99%

Peso molecular: 507.627

Ref: BP-SBP60020

Cytochalasin D

CAS: 22144-77-0

Inhibits actin polymerization

Fórmula: C₃₀H₃₇NO₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 507.62 g/mol

Ref: 3D-FC29349