CAS 221877-54-9

Zotarolimus

Descrição:

Zotarolimus, com o número CAS 221877-54-9, é um composto macrolídeo sintético que pertence à classe de agentes imunossupressores. É utilizado principalmente na área médica como um revestimento de stent liberador de fármacos para prevenir a reestenose nas artérias coronárias após a angioplastia. Zotarolimus atua inibindo a proliferação de células musculares lisas e modulando a resposta imunológica, o que ajuda a reduzir o risco de obstrução arterial. O composto exibe um mecanismo de ação semelhante ao do sirolimus, visando a via do alvo mamífero da rapamicina (mTOR), que é crucial para o crescimento celular e o metabolismo. Zotarolimus é caracterizado por sua natureza lipofílica, que melhora sua capacidade de aderir às superfícies dos stents e liberar gradualmente ao longo do tempo. Sua farmacocinética envolve uma meia-vida relativamente longa, permitindo efeitos terapêuticos sustentados. Perfis de segurança e eficácia foram estabelecidos por meio de estudos clínicos, tornando-o uma ferramenta valiosa na cardiologia intervencionista. No entanto, como todos os medicamentos, pode ter efeitos colaterais e contraindicações potenciais que precisam ser considerados na prática clínica.

Fórmula:C₅₂H₇₉N₅O₁₂

InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

Chave InChI:InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES:O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

Sinónimos:

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
42-(1-Tetrazolyl)rapamycin
A 179578
Abt 578
Endeavor
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Resolute
Unii-H4gxr80ize
Zotarolimus
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ZotaroliMus(ABT-578)
Zotarolimus, &gt
ZotaroliMus, >90%
ZOTAROLIMUS USP/EP/BP
ZOTAROLIMUS Impurities
ZotaroliMus API
42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
CS-1162
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Ver mais sinónimos

Pureza (%)

100

7 produtos.

+ Info
Zotarolimus
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:95%
Cor e Forma:Solid
Peso molecular:966.2100
Ref: IN-DA00BF84
1mg
96,00€
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5mg
162,00€
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25mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus
Pureza:≥95%
Peso molecular:966.21g/mol
Ref: 54-BUP04934
1mg
53,00€
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5mg
113,00€
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10mg
186,00€
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Zotarolimus
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₉N₅O₁₂
Cor e Forma:Off-White Solid
Peso molecular:966.23
Ref: 4Z-Z-141
5mg
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10mg
698,00€
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25mg
1.153,00€
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50mg
2.002,00€
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100mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:95% - 98.01%
Cor e Forma:Solid
Peso molecular:966.21
Ref: TM-T6033
+ Info
Zotarolimus-d3
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₆D₃N₅O₁₂
Peso molecular:969.23
Ref: 4Z-Z-142
5mg
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Zotarolimus
CAS:
- 221877-54-9
<p>Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.</p>
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:Min. 95%
Cor e Forma:White Powder
Peso molecular:966.21 g/mol
Ref: 3D-FZ28788
2mg
135,00€
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5mg
166,00€
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10mg
224,00€
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25mg
382,00€
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Zotarolimus-d3, >90% (contains d0)
Produto ControladoTenha em atenção que se trata de um produto controlado em alguns países e que tem de ser tratado em conformidade com os regulamentos relevantes. Esteja ciente de que isto pode implicar despesas e documentação adicionais.
CAS:
- 221877-54-9
Fórmula:C₅₂D₃H₇₆N₅O₁₂
Cor e Forma:Neat
Peso molecular:969.229
Ref: TR-Z700802
2500µg
1.509,00€
IVA não incluído
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