CAS 22260-51-1

Mesilato de bromocriptina

Descrição:

Mesilato de bromocriptina é um composto sintético utilizado principalmente como agonista da dopamina no tratamento de várias condições médicas, incluindo a doença de Parkinson, a hiperprolactinemia e certos tipos de acromegalia. É derivado de alcaloides do ergot e funciona estimulando os receptores de dopamina, particularmente os receptores D2, o que ajuda a regular os níveis hormonais e melhorar o controle motor. A forma de sal mesilato melhora sua solubilidade e estabilidade, tornando-o adequado para formulações farmacêuticas. Mesilato de bromocriptina é tipicamente administrado por via oral e é conhecido por sua absorção e biodisponibilidade relativamente rápidas. Os efeitos colaterais comuns podem incluir náuseas, tontura e fadiga, refletindo sua atividade no sistema nervoso central. O composto é classificado como um medicamento sob prescrição e deve ser usado sob supervisão médica devido a potenciais interações com outros medicamentos e contraindicações em certas populações de pacientes. Sua estrutura química inclui um átomo de bromo, que contribui para suas propriedades farmacológicas, e é frequentemente estudado por seus efeitos nas funções neuroendócrinas.

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

InChI: InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2,3,4)/t18-,23-,24+,25+,31-,32+;/m1./s1

Chave InChI: InChIKey=NOJMTMIRQRDZMT-GSPXQYRGSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=C(Br)NC6C=CC5)(C(C)C)O1)[C@@H](CC(C)C)C(=O)N7[C@]2(CCC7)[H].S(C)(=O)(=O)O

Sinónimos:

• (+)-Bromocriptine methanesulfonate
• (5'Alpha)-2-Bromo-12'-Hydroxy-5'-(2-Methylpropyl)-3',6',18-Trioxo-2'-(Propan-2-Yl)Ergotaman Methanesulfonate (1:1)
• (5Xi,5'Alpha)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• (8Xi,12'Xi)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• 2-bromo-A-ergocryptine methanesulfonate salt
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• Bagren
• Bromocriptine Mesylate
• Bromocryptine mesylate
• Bromocryptine methanesulfonate
• Cb 154
• Cycloset
• Ergocryptine, 2-bromo-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5′α)-, monomethanesulfonate (salt)
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• Parlodel

Bromocriptine Mesilate

CAS: 22260-51-1

Cor e Forma: Neat

Ref: 61-FOR1159.00

Bromocriptine mesilate

CAS: 22260-51-1

Bromocriptine mesilate

Fórmula: C₃₂H₄₀BrN₅O₅

Pureza: 86.2%

Cor e Forma: Off-White

Peso molecular: 653.22128

Ref: 47-50

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

Fórmula: C₃₃H₄₄BrN₅O₈S

Peso molecular: 750.7002

Ref: 41-Y0000677

BROMOCRIPTINE MESILATE CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE CRS

Fórmula: C₃₃H₄₄BrN₅O₈S

Cor e Forma: Crystalline Powder. White. Whitish. Powder.

Peso molecular: 750.7002

Ref: 41-B1150000

Bromocriptine Mesylate

CAS: 22260-51-1

Alkaloids of rye ergot and their derivatives; salts thereof, nesoi

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Cor e Forma: White Off-White Powder

Peso molecular: 749.2094

Ref: 45-1076501

Bromocriptine mesylate

CAS: 22260-51-1

Fórmula: C₃₃H₄₄BrN₅O₈S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 750.7002

Ref: IN-DA007P10

Bromocriptine Mesylate

CAS: 22260-51-1

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Cor e Forma: White To Off-White Solid

Peso molecular: 654.61 96.10

Ref: 4Z-B-333

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Peso molecular: 750.7g/mol

Ref: 54-BI12183

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Pureza: ≥98%

Peso molecular: 750.7g/mol

Ref: 54-BUP17549

Bromocriptine Mesilate

Produto Controlado

CAS: 22260-51-1

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 750.70

Ref: 86-MM1159.00

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)

Fórmula: C₃₃H₄₄BrN₅O₈S

Pureza: 99.85% - 99.96%

Cor e Forma: White Solid

Peso molecular: 750.7

Ref: TM-T5842

Bromocryptine mesylate

CAS: 22260-51-1

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄SO₃

Pureza: 98.0 - 102.0 % (anhydrous basis)

Cor e Forma: White powder

Peso molecular: 750.70

Ref: 7W-GP6938

Bromocriptine mesylate

Produto Controlado

CAS: 22260-51-1

Dopamine (D2) agonist; inhibits neuronal NOS enzyme

Fórmula: C₃₂H₄₀BrN₅O₅•CH₄O₃S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 750.7 g/mol

Ref: 3D-FB19032

Bromocriptine mesylate - Bio-X ™

Produto Controlado

CAS: 22260-51-1

Bromocriptine is a dopamine D2 receptor agonist that is used for the treatment of galactorrhoea which is due to hyperprolactinemia and other prolactin-related conditions. This drug is an ergot alkaloid derivative that inhibits prolactin secretion. Additionally, it can be used to management signs and symptoms of Parkinsonian syndrome. Research has indicated this drug for pulmonary fibrosis as well.

Fórmula: C₃₃H₄₄BrN₅O₈S

Pureza: Min. 99 Area-%

Cor e Forma: Powder

Peso molecular: 750.7 g/mol

Ref: 3D-BB164266

2-Bromo α-Ergocryptine Mesylate

Produto Controlado

CAS: 22260-51-1

Applications The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. 2-Bromo-α-Ergocryptine is a dopamine receptor agonist and a derivative of the ergotoxin group of ergot alkaloids (2). It is also a prolactin inhibitor (3).
References (1) Ptácek, R., et al.: Med Sci Monit. 17, RA215 (2011) (2) Lieberman, A. N. and Goldstein, M.: Pharmacol Rev. 37, 217 (1985) (3) Nazli, K., et al.: Br J Clin Pract. 43, 322 (1989)

Fórmula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Cor e Forma: White To Off-White

Peso molecular: 750.70

Ref: TR-B682600