CAS 22494-42-4

Diflunisal

Descrição:

Diflunisal é um medicamento anti-inflamatório não esteroidal (AINE) que é utilizado principalmente por suas propriedades analgésicas e anti-inflamatórias. É caracterizado por sua capacidade de inibir a enzima ciclooxigenase (COX), que desempenha um papel crucial na síntese de prostaglandinas, compostos envolvidos na inflamação e na sinalização da dor. Diflunisal é tipicamente administrado na forma de comprimidos e é conhecido por sua meia-vida relativamente longa, permitindo uma dosagem menos frequente em comparação com outros AINEs. A estrutura química de Diflunisal inclui um derivado do ácido salicílico com dois átomos de flúor, o que aumenta sua eficácia anti-inflamatória. É frequentemente utilizado no manejo de condições como osteoartrite e artrite reumatoide. Embora geralmente bem tolerado, Diflunisal pode causar efeitos colaterais típicos dos AINEs, incluindo desconforto gastrointestinal e potenciais riscos cardiovasculares. Assim como qualquer medicamento, é essencial usar Diflunisal sob supervisão médica para mitigar riscos e garantir o uso terapêutico apropriado.

Fórmula: C₁₃H₈F₂O₃

InChI: InChI=1/C13H8F2O3/c14-10-3-1-8(6-11(10)15)7-2-4-12(16)9(5-7)13(17)18/h1-6,16H,(H,17,18)

Chave InChI: InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N

SMILES: FC1=C(C=CC(F)=C1)C2=CC(C(O)=O)=C(O)C=C2

Sinónimos:

• 2',4'-Difluoro-4-Hydroxybiphenyl-3-Carboxylic Acid
• 2-Hydroxy-5-(2,4-difluorophenyl)benzoic acid
• 2′,4′-Difluoro-4-hydroxy[1,1′-biphenyl]-3-carboxylic acid
• 2′,4′-Difluoro-4-hydroxybiphenyl-3-carboxylic acid
• 3-Biphenylcarboxylic acid, 2',4'-difluoro-4-hydroxy-
• 3-Biphenylcarboxylic acid, 2′,4′-difluoro-4-hydroxy-
• 5-(2,4-Difluorophenyl) salicylic acid
• 5-(3,4-Difluorophenyl)-2-Hydroxy-Benzoic Acid
• Adomal
• Difludol
• Diflusinal
• Dolisal
• Doloban
• Dolobid
• Dolobis
• Flovacil
• Fluniget
• Fluodonil
• Flustar
• Mk 647
• [1,1'-Biphenyl]-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
• [1,1′-Biphenyl]-3-carboxylic acid, 2′,4′-difluoro-4-hydroxy-
• Diflunisal
• 2-(hydroxy)-5-(2,4-difluorophenyl)benzoicacid
• LABOTEST-BB LT00771921
• 1’-biphenyl]-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-[
• 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid
• 2',4'-DIFLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID
• 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicaci
• 1’-biphenyl)-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-(
• 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicacid
• 2',4'-DIFLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
• 2',4'-Difluoro-4-hydroxy-(1',1-diphenyl)-3-carboxylic acid

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Pureza: >98.0%(GC)

Cor e Forma: White to Almost white powder to crystaline

Peso molecular: 250.20

Ref: 3B-D5875

Diflunisal

CAS: 22494-42-4

Cor e Forma: Neat

Ref: 61-FOR3050.00

Diflunisal

CAS: 22494-42-4

Carboxylic acids with phenol function but without other

Fórmula: C₁₃H₈F₂O₃

Cor e Forma: Powder

Peso molecular: 250.04415

Ref: 45-1197506

[1,​1'-​Biphenyl]​-​3-​carboxylic acid, 2',​4'-​difluoro-​4-​hydroxy-

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 250.1976

Ref: IN-DA003PIH

Diflunisal

CAS: 22494-42-4

Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

Fórmula: C₁₃H₈F₂O₃

Pureza: 98.92% - 99.42%

Cor e Forma: Solid

Peso molecular: 250.20

Ref: TM-T0808

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Pureza: ≥ 98%

Cor e Forma: White or off-white powder

Peso molecular: 250.20

Ref: 7W-GL2053

Diflunisal

CAS: 22494-42-4

Diflunisal

Pureza: ≥98%

Peso molecular: 250.2g/mol

Ref: 54-BUP15779

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 250.20

Ref: 4Z-D-523

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Cor e Forma: Neat

Peso molecular: 250.20

Ref: 04-C12631600

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Cor e Forma: Neat

Peso molecular: 250.20

Ref: 86-MM3050.00

2',4'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid

CAS: 22494-42-4

2',4'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid

Fórmula: C₁₃H₈F₂O₃

Pureza: 98%

Cor e Forma: pale yellow solid

Peso molecular: 250.20g/mol

Ref: 54-PC11123

Diflunisal

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Peso molecular: 250.20

Ref: ST-EA-CP-D50000

Diflunisal

Produto Controlado

CAS: 22494-42-4

Applications Diflunisal acts as an analgesic agent, used in Alzheimer’s studies (1,2,3) as an anti-inflammatory. As well as in autolytic regulation of human kallikrein -related peptidase 6 (4).
References 1. Little, S. et al.: J Biol Chem. 1997 Oct 3;272(40):25135-42.2. Diamandis, E. et al.: Clin. Biochem. 2000 Jul;33(5):369-75.3. Hutchinson, S. et al.: Clin. Chem. 2003 May;49(5):746-51. 4. Baber, S et al.: Biochemistry. 2007 May 1;46(17):5209-17.

Fórmula: C₁₃H₈F₂O₃

Cor e Forma: Neat

Peso molecular: 250.20

Ref: TR-D445751

Diflunisal-d3

Produto Controlado

CAS: 22494-42-4

Applications Labelled Diflunisal. Analgesic; anti-inflammatory.
References Little, S., et al.: J. Biol. Chem., 272, 25135 (1997), Diamandis, E., et al.: Clin. Biochem., 33, 369 (2000), Hutchinson, S., et al.: Clin. Chem., 49, 746 (2003), Blaber, S., et al.: Biochemistry, 46, 5209 (2007),

Fórmula: C₁₃D₃H₅F₂O₃

Cor e Forma: Neat

Peso molecular: 253.216

Ref: TR-D445752

Diflunisal

CAS: 22494-42-4

Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID), which is a synthetic derivative of salicylic acid. It is primarily sourced through chemical synthesis rather than extraction from natural elements. Diflunisal functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a crucial role in the biosynthesis of prostaglandins. This inhibition results in reduced production of prostaglandins, compounds involved in inflammation and pain signaling pathways.

Fórmula: C₁₃H₈F₂O₃

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 250.2 g/mol

Ref: 3D-FD16025

2′,4′-Difluoro-4-hydroxy-biphenyl-3-carboxylic acid

CAS: 22494-42-4

Fórmula: C₁₃H₈F₂O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 250.201

Ref: 10-F031599