CAS 228266-40-8

N,β,β-Trimetil-L-fenilalanil-N-[(1S,2E)-3-carboxi-1-(1-metiletil)-2-buten-1-il]-N,3-dimetil-L-valinamida

Descrição:

N,β,β-Trimetil-L-fenilalanil-N-[(1S,2E)-3-carboxi-1-(1-metiletil)-2-buten-1-il]-N,3-dimetil-L-valinamida, com número CAS 228266-40-8, é um composto sintético que pertence à classe de derivados de aminoácidos. Esta substância apresenta uma estrutura complexa caracterizada por múltiplos centros quirais, o que contribui para sua potencial atividade biológica. A presença dos grupos de fenilalanina e valina sugere que pode interagir com sistemas biológicos, possivelmente influenciando a síntese de proteínas ou a atividade enzimática. Os grupos funcionais de ácido carboxílico e alceno do composto indicam uma reatividade potencial, tornando-o de interesse na química medicinal e no design de fármacos. Sua estereoequilibrio específico também pode desempenhar um papel crucial em suas propriedades farmacológicas, afetando a afinidade de ligação e a seletividade por alvos biológicos. Assim como muitos compostos sintéticos, entender sua solubilidade, estabilidade e reatividade sob várias condições é essencial para aplicações em pesquisa e desenvolvimento. Estudos adicionais seriam necessários para elucidar seu perfil biológico completo e possíveis usos terapêuticos.

Fórmula: C₂₇H₄₃N₃O₄

InChI: InChI=1S/C27H43N3O4/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34)/b18-16+/t20-,21-,22-/m1/s1

Chave InChI: InChIKey=CNTMOLDWXSVYKD-PSRNMDMQSA-N

SMILES: [C@H](C(C)(C)C1=CC=CC=C1)(C(N[C@H](C(N([C@H](/C=C(/C(O)=O)\C)C(C)C)C)=O)[C@@](C)(C)C)=O)NC

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Valinamide, N,β,β-trimethyl-<smallcap>L</span>-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl-
• <span class="text-smallcaps">L</smallcap>-Valinamide, N,β,β-trimethyl-<smallcap>L</span>-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-
• Hti 286
• N,beta,beta-Trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-L-valinamide
• N,β,β-Trimethyl-<span class="text-smallcaps">L</smallcap>-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl-<smallcap>L</span>-valinamide
• Spa 110
• L-Valinamide, N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl-
• N,β,β-Trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl-L-valinamide
• L-Valinamide, N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-

L-Valinamide,N,b,b-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-butenyl]-N,3-dimethyl-

CAS: 228266-40-8

Fórmula: C₂₇H₄₃N₃O₄

Pureza: 99.65%

Peso molecular: 473.6480

Ref: IN-DA00BF4U

Taltobulin

CAS: 228266-40-8

Taltobulin is a nitrogen-containing analog that binds to the α subunit of the renal tubular adenylate cyclase and inhibits its activity. This results in decreased levels of cyclic AMP and less activation of protein kinases, which are important for regulating cellular functions. Taltobulin has been shown to inhibit cancer cells in culture as well as bladder and other cancers in animal studies. It also has minimal toxicity, with most side effects being mild and reversible. Taltobulin is used to treat autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. Antibodies against taltobulin have been found in patients who were treated with this drug. These antibodies were found to be specific for the α subunit of the renal tubular adenylate cyclase and may be used as a diagnostic marker for patients who have been exposed to taltobulin or other similar drugs.

Fórmula: C₂₇H₄₃N₃O₄

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 473.65 g/mol

Ref: 3D-DJA26640

Taltobulin

CAS: 228266-40-8

Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.

Fórmula: C₂₇H₄₃N₃O₄

Pureza: 99.86%

Cor e Forma: Solid

Peso molecular: 473.65

Ref: TM-TQ0141