CAS 231277-92-2

Lapatinib

Descrição:

Lapatinib é um inibidor de tirosina quinase de pequenas moléculas usado principalmente no tratamento de certos tipos de câncer de mama, particularmente aqueles que são HER2-positivos. Funciona inibindo a atividade do receptor do fator de crescimento epidérmico (EGFR) e HER2, que estão envolvidos na proliferação e sobrevivência das células cancerosas. Lapatinib é tipicamente administrado por via oral e muitas vezes é usado em combinação com outras terapias, como capecitabina, para aumentar sua eficácia. O composto tem uma fórmula molecular que reflete sua estrutura complexa, que inclui múltiplos anéis aromáticos e grupos funcionais que contribuem para sua atividade farmacológica. Lapatinib é caracterizado por sua solubilidade moderada em solventes orgânicos e solubilidade relativamente baixa em água, o que pode influenciar sua biodisponibilidade. Os efeitos colaterais podem incluir diarreia, erupção cutânea e potenciais problemas cardíacos, exigindo monitoramento cuidadoso durante o tratamento. No geral, Lapatinib representa uma abordagem terapêutica direcionada em oncologia, exemplificando a mudança em direção à medicina personalizada no tratamento do câncer.

Fórmula: C₂₉H₂₆ClFN₄O₄S

InChI: InChI=1/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

Chave InChI: InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4

Sinónimos:

• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-
• 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
• Gd 2016
• Gsk 572016
• Gw 572016
• Gw 572016X
• Lapatinib base
• N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
• N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
• N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
• N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine
• N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
• Tycerb
• Tyverb
• Lapatinib

Lapatinib

CAS: 231277-92-2

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 581.06

Ref: 3B-L0360

N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

CAS: 231277-92-2

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 581.0575

Ref: IN-DA0039KT

Lapatinib

CAS: 231277-92-2

Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: 99.00% - 99.81%

Cor e Forma: Powder

Peso molecular: 581.06

Ref: TM-T0078

Lapatinib

CAS: 231277-92-2

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: ≥ 99.0%

Cor e Forma: Pale yellow to yellow powder

Peso molecular: 581.06

Ref: 7W-GP6924

Lapatinib

CAS: 231277-92-2

Lapatinib

Pureza: ≥98%

Peso molecular: 581.06g/mol

Ref: 54-BUP16996

Lapatinib

CAS: 231277-92-2

Fórmula: C₂₉H₂₆ClFN₄O₄S

Cor e Forma: Yellow Solid

Peso molecular: 581.06

Ref: 4Z-L-251

Lapatinib

CAS: 231277-92-2

Lapatinib

Pureza: 98%

Peso molecular: 581.06g/mol

Ref: 54-PC108772

Lapatinib

Produto Controlado

CAS: 231277-92-2

Applications Lapatinib is a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. This drug is used to treat breast cancer, especially metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy.
References Konecny, G., et al.: Cancer Res., 66, 1630 (2006); Geyer, C., et al.: N. Engl. J. Med., 355, 2733 (2006);

Fórmula: C₂₉H₂₆ClFN₄O₄S

Cor e Forma: Light Yellow

Peso molecular: 581.06

Ref: TR-L175808

Lapatinib

CAS: 231277-92-2

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: Min. 95%

Cor e Forma: Slightly Yellow Powder

Peso molecular: 581.06 g/mol

Ref: 3D-FC12433

Lapatinib base - Bio-X ™

CAS: 231277-92-2

Lapatinib is an antineoplastic agent used to treat breast and lung cancer. This drug is also a tyrosine kinase inhibitor and inhibits human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1). Lapatinib has shown to inhibit ERBB-driven tumor cell growth in vitro and in various animal models.

Fórmula: C₂₉H₂₆ClFN₄O₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 581.06 g/mol

Ref: 3D-BC164610

Lapatinib ditosylate monohydrate

CAS: 231277-92-2

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Fórmula: C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂•H₂O

Pureza: Min. 95%

Peso molecular: 943.48 g/mol

Ref: 3D-FL24843