CAS 23180-57-6

Paeoniflorina

Descrição:

Paeoniflorina é um composto natural extraído principalmente das raízes da planta de peônia, particularmente Paeonia lactiflora. É classificado como um glicosídeo monoterpeno e é conhecido por suas várias propriedades farmacológicas. Paeoniflorina exibe efeitos anti-inflamatórios, analgésicos e neuroprotetores, tornando-o de interesse na medicina tradicional e na farmacologia moderna. O composto é frequentemente estudado por suas potenciais aplicações terapêuticas em condições como dor, ansiedade e doenças neurodegenerativas. Em termos de sua estrutura química, Paeoniflorina consiste em uma porção de glicose ligada a um composto fenólico, o que contribui para sua atividade biológica. Geralmente é solúvel em água e exibe estabilidade sob várias condições de pH. Além disso, foi demonstrado que Paeoniflorina modula várias vias de sinalização, aumentando seu potencial como agente terapêutico. Seu perfil de segurança é geralmente favorável, mas mais pesquisas são necessárias para entender completamente seus mecanismos de ação e potenciais efeitos colaterais.

Fórmula: C₂₃H₂₈O₁₁

InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1

Chave InChI: InChIKey=YKRGDOXKVOZESV-WRJNSLSBSA-N

SMILES: C(OC(=O)C1=CC=CC=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@]6(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C6)[H]

Sinónimos:

• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Nsc 178886
• Paeoniflorin
• Peoniflorin
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-Glucopyranosid, 5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5ba)]-
• β-D-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopiranosido, 5b-[(benzoiloxi)metil]tetrahidro-5-hidroxi-2-metil-2,5-metano-1H-3,4-dioxaciclobuta[cd]pentalen-1a(2H)-il, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopyrannoside, [(benzoyloxy)methyl]-5b tetrahydrohydroxy-5 methyl-2 methano-2,5 1H-dioxacyclo-3,4 buta[cd]pentalenyl 1a(2H), [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• Paeoniflorm
• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-D-glucopyranoside
• [(3S,3aR,6S,7aR)-3-(beta-D-glucopyranosyloxy)-7a-hydroxy-6-methyloctahydro-2,6-epoxy-1-benzofuran-3-yl]methyl benzoate
• Reishi Mushroom
• [(1aR,2R,3aR,5S,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [1a-(hexopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [(1aR,2S,3aR,5R,5aR)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-D-glucopyranoside deriv.
• Reishi Mushroom Extract
• [(1aR,2S,3aR,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate

Paeoniflorin

CAS: 23180-57-6

Fórmula: C₂₃H₂₈O₁₁

Pureza: >95.0%(NMR)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 480.47

Ref: 3B-P1876

PAEONIFLORIN CRS

CAS: 23180-57-6

PAEONIFLORIN CRS

Fórmula: C₂₃H₂₈O₁₁

Peso molecular: 480.4618

Ref: 41-Y0001856

Paeoniflorin

CAS: 23180-57-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Fórmula: C₂₃H₂₈O₁₁

Cor e Forma: Off-White White Powder

Peso molecular: 480.16316

Ref: 45-1491616

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Pureza: ≥95%

Peso molecular: 480.46g/mol

Ref: 54-BUP15107

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Pureza: 98%

Peso molecular: 480.46g/mol

Ref: 54-OR1027748

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin, a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases.

Fórmula: C₂₃H₂₈O₁₁

Pureza: 95%~99%

Peso molecular: 480.466

Ref: BP-BP1056

Paeoniflorin

CAS: 23180-57-6

Fórmula: C₂₃H₂₈O₁₁

Peso molecular: 480.47

Ref: 4Z-P-311001

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.

Fórmula: C₂₃H₂₈O₁₁

Pureza: 96.9% - 97.43%

Cor e Forma: White Fine Powder

Peso molecular: 480.46

Ref: TM-T2230

Paeoniflorin

CAS: 23180-57-6

Fórmula: C₂₃H₂₈O₁₁

Pureza: ≥ 97.5%

Cor e Forma: White powder

Peso molecular: 480.46

Ref: 7W-GC2063

Paeoniflorin RS

CAS: 23180-57-6

Cor e Forma: White Solid Powder

Ref: 2K-1144000021

Paeoniflorin

CAS: 23180-57-6

Natural glycoside

Fórmula: C₂₃H₂₈O₁₁

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 480.47

Ref: 5G-89384

Paeoniflorin (>80%)

Produto Controlado

CAS: 23180-57-6

Applications Paeoniflorin is an active compound of the Paeonia root. Paeoniflorin inhibits Aβ25-35-induced mitochondrial dysfunction, which includes decreased mitochondrial membrane potential, increased Bax/Bcl-2 ratio, cytochrome c release and activity of caspase-3 and caspase-9. Paeoniflorin could attenuate or restore the viability loss, apoptotic increase, and ROS production induced by Aβ25-35 in SH-SY5Y cells.
References Yuan,Y., et. al.: Int. J. Mol. Sci., 14, 18502 (2013); Wang, K., et. al.: Cell Mol. Neurobiol., 34, 227 (2014)

Fórmula: C₂₃H₂₈O₁₁

Pureza: >80%

Cor e Forma: Neat

Peso molecular: 480.46

Ref: TR-P133830

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin is a bioactive compound, which is a monoterpene glycoside derived from the roots of Paeonia lactiflora, commonly known as peony. This compound functions through multiple mechanisms, including the modulation of calcium channels, the inhibition of the production of pro-inflammatory cytokines, and the regulation of neurotransmitter levels. It effectively exhibits anti-inflammatory and immunomodulatory effects.

Fórmula: C₂₃H₂₈O₁₁

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 480.46 g/mol

Ref: 3D-MP08290

PAEONIFLORIN

CAS: 23180-57-6

Pureza: 95%

Peso molecular: 480.4660034

Ref: 10-F859163

b-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl

CAS: 23180-57-6

Fórmula: C₂₃H₂₈O₁₁

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 480.4618

Ref: IN-DA00I4J3

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Fórmula: C₂₃H₂₈O₁₁

Pureza: 88.6%

Cor e Forma: Off-White

Peso molecular: 480.16316

Ref: 47-769