CAS 23327-57-3

(±)-Cloridrato de nefopam

Descrição:

(±)-Cloridrato de nefopam é um composto sintético reconhecido principalmente por suas propriedades analgésicas. É classificado como um analgésico não opioide e é frequentemente usado para gerenciar a dor, particularmente em casos onde opioides tradicionais podem não ser adequados. A substância exibe um mecanismo de ação único, principalmente através da inibição da recaptação de neurotransmissores como serotonina, norepinefrina e dopamina, o que contribui para seus efeitos analgésicos. Quimicamente, é uma mistura racêmica, o que significa que contém partes iguais de dois enantiômeros, que podem exibir diferentes atividades farmacológicas. O cloridrato de nefopam é tipicamente administrado em sua forma de sal cloridrato, melhorando sua solubilidade e estabilidade. O composto é conhecido por sua relativamente baixa incidência de efeitos colaterais em comparação com opioides, tornando-se uma alternativa valiosa no manejo da dor. No entanto, ainda pode causar alguns efeitos adversos, incluindo náuseas e tontura. Assim como qualquer medicamento, seu uso deve ser orientado por um profissional de saúde, considerando as necessidades individuais do paciente e as potenciais interações com outros medicamentos.

Fórmula: C₁₇H₁₉NO·ClH

InChI: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

Chave InChI: InChIKey=CNNVSINJDJNHQK-UHFFFAOYSA-N

SMILES: CN1CC=2C(C(OCC1)C3=CC=CC=C3)=CC=CC2.Cl

Sinónimos:

• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
• 3,4,5,6-Tetrahydro-5-Methyl-1-Phenyl-1H-2,5-Benzoxazocine Hydrochloride
• 3-Methyl-7-Phenyl-6-Oxa-3-Azabicyclo[6.4.0]Dodeca-8,10,12-Triene Hydrochloride
• 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride
• Acupan
• Fenazoxine
• Fenazoxine hydrochloride
• Nefopam HCl
• R 738
• Nefopam hydrochloride

Nefopam Hydrochloride

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 289.80

Ref: 3B-N1169

5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride

CAS: 23327-57-3

Pureza: 95.0%

Cor e Forma: Solid

Peso molecular: 289.79998779296875

Ref: 10-F241971

Nefopam Hydrochloride

CAS: 23327-57-3

Cor e Forma: Neat

Ref: 61-FOR1189.00

Nefopam Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 23327-57-3

Cor e Forma: Single Solution

Ref: 61-AMP1189.00-01

(±)-Nefopam (hydrochloride)

CAS: 23327-57-3

Fórmula: C₁₇H₂₀ClNO

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 289.7998

Ref: IN-DA002MVZ

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Fórmula: C₁₇H₂₀ClNO

Pureza: 99.32% - 99.85%

Cor e Forma: Solid

Peso molecular: 289.8

Ref: TM-T0470

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride

Pureza: ≥98%

Peso molecular: 289.8g/mol

Ref: 54-BUP18744

Nefopam hydrochloride

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Pureza: ≥ 98.0%

Cor e Forma: White to off-white or beige powder

Peso molecular: 289.80

Ref: 7W-GP9613

Nefopam HCl

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 253.35 36.46

Ref: 4Z-N-371

Nefopam Hydrochloride

CAS: 23327-57-3

Nefopam Hydrochloride

Pureza: 98%

Peso molecular: 289.8g/mol

Ref: 54-OR1029203

Nefopam-d4 HCl

CAS: 23327-57-3

Fórmula: C₁₇H₁₅D₄NO·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 257.37 36.46

Ref: 4Z-N-376

Nefopam Hydrochloride

Produto Controlado

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·ClH

Cor e Forma: Neat

Peso molecular: 289.80

Ref: 86-MM1189.00

Nefopam Hydrochloride

Produto Controlado

CAS: 23327-57-3

Applications A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Fórmula: C₁₇H₁₉NO·ClH

Cor e Forma: White To Off-White

Peso molecular: 289.80

Ref: TR-N389400

Nefopam HCl - Bio-X ™

CAS: 23327-57-3

Nefopam is a non-narcotic analgesic drug that has been used in the treatment of chronic pain. It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Nefopam is also a nasal drug that relieves pain by blocking neurokinin 1 receptor, which reduces the production of prostaglandins. Nefopam acts in the brain and spinal cord to relieve pain through different mechanisms such as antinociceptive effects from triple monoamine reuptake inhibition, and antihyperalgesic activity through modulation of glutamatergic transmission.

Fórmula: C₁₇H₁₉NO·HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 289.8 g/mol

Ref: 3D-FN65100

Nefopam hydrochloride

CAS: 23327-57-3

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride (THPP) is a drug that is used as an analgesic and anti-inflammatory agent. THPP interacts with nonsteroidal anti-inflammatory drugs (NSAIDs) to cause neuronal death. It has been shown to inhibit the plate test for prostaglandin synthesis in human erythrocytes. The disulfide bond between cysteine residues on the protein molecule is susceptible to oxidative cleavage by reactive oxygen species from reactive oxygen species such as hydrogen peroxide and lipid peroxidation products. This can lead to the formation of a thiolate ion and a sulfenic acid intermediate. THPP is also known to produce chronic oral toxicity in rats at doses of 837 mg/kg/day for two months. A chemiluminescence method was used to measure the reaction

Fórmula: C₁₇H₂₀ClNO

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 289.8 g/mol

Ref: 3D-FN26174

N-Hydroxymethyl Nefopam N-Oxide

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO₃

Cor e Forma: White To Off-White Solid

Peso molecular: 285.35

Ref: 4Z-N-3710