CAS 23541-50-6

Cloridrato de daunorrubicina

Descrição:

Cloridrato de daunorrubicina é um antibiótico antraciclínico derivado da bactéria Streptomyces peucetius, utilizado principalmente na terapia do câncer, particularmente para tratar leucemia mieloide aguda e leucemia linfoblástica aguda. Apresenta uma cor vermelho-alaranjada e é conhecido por suas potentes propriedades citotóxicas, que interferem na replicação e transcrição do DNA ao intercalar-se nas cadeias de DNA e inibir a topoisomerase II. Esse mecanismo leva à apoptose em células cancerosas que se dividem rapidamente. Cloridrato de daunorrubicina é tipicamente administrado por via intravenosa e possui um perfil de efeitos colaterais bem documentado, incluindo cardiotoxicidade, mielossupressão e potencial para malignidades secundárias. Sua solubilidade em água é aumentada pela forma de sal hidroclorídrico, tornando-o adequado para uso clínico. A farmacocinética do composto envolve metabolismo hepático e excreção renal, e muitas vezes é utilizado em combinação com outros agentes quimioterápicos para aumentar a eficácia terapêutica. Devido aos seus significativos benefícios terapêuticos e riscos associados, o monitoramento cuidadoso durante o tratamento é essencial.

Fórmula: C₂₇H₂₉NO₁₀·ClH

InChI: InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

Chave InChI: InChIKey=GUGHGUXZJWAIAS-QQYBVWGSSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl

Sinónimos:

• (1R,3R)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-D-lyxo-hexopyranoside hydrochloride
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• Cerubidine
• Daunoblastin
• Daunomycin chlorohydrate
• Daunorubicin hydrochloride
• Daunorubicin, HCl
• Ndc 0082-4155
• Ondena
• RP 13057 hydrochloride
• Rubidomycin Hydrochloride
• Daunomycin, hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

Daunorubicin Hydrochloride

CAS: 20830-81-3, 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·HCl

Pureza: >98.0%(N)

Cor e Forma: Orange to Red powder to crystal

Peso molecular: 563.98

Ref: 3B-D4532

Daunorubicin hydrochloride

CAS: 23541-50-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₂₇H₃₀ClNO₁₀

Cor e Forma: Powder, Orange to red

Peso molecular: 563.98

Ref: 02-J60224

DAUNORUBICIN HYDROCHLORIDE CRS

CAS: 23541-50-6

DAUNORUBICIN HYDROCHLORIDE CRS

Fórmula: C₂₇H₃₀ClNO₁₀

Cor e Forma: Powder

Peso molecular: 563.9808

Ref: 41-D0125000

Daunorubicin Hydrochloride

CAS: 23541-50-6

Antibiotics nesoi

Fórmula: C₂₇H₂₉NO₁₀·HCI

Cor e Forma: Red Orange Needles Crystalline Powder

Peso molecular: 667.09144

Ref: 45-1164700

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein

Fórmula: C₂₇H₂₉NO₁₀·HCl

Pureza: 96.21% - 99.53%

Cor e Forma: Cancer Drug

Peso molecular: 563.99

Ref: TM-T1511

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

CAS: 23541-50-6

Fórmula: C₂₇H₃₀ClNO₁₀

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 563.9808

Ref: IN-DA0037I5

Daunorubicin HCl (Epirubicin EP Impurity D HCl)

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·HCl

Cor e Forma: Orange Red Solid

Peso molecular: 527.53 36.46

Ref: 4Z-D-481

Daunorubicin hydrochloride, EP grade

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·HCl

Pureza: ≥ 90.0% (anhydrous)

Cor e Forma: Orange-red crystalline powder

Peso molecular: 563.98

Ref: 7W-GA7448

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Pureza: ≥95%

Peso molecular: 563.99g/mol

Ref: 54-BUP15460

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Pureza: 98%

Peso molecular: 563.9808g/mol

Ref: 54-BID0122

Daunorubicin hydrochloride

Produto Controlado

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·ClH

Cor e Forma: Neat

Peso molecular: 563.98

Ref: 04-C11968000

Daunorubicin Hydrochloride

Produto Controlado

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀·ClH

Cor e Forma: Neat

Peso molecular: 563.98

Ref: 86-MM0284.00

Daunorubicin Hydrochloride

CAS: 23541-50-6

Applications Anthracycline antibiotic related to the rhodomycins. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, Z., et al.: J. Pharmacol. Experim. Ther., 327, 474 (2008), Zhao, Y., et al.: Int. J. Pharm., 379, 90 (2009), Bayne, W., et al.: J. Pharm. Sci., 98, 2540 (2009),

Fórmula: C₂₇H₂₉NO₁₀·ClH

Cor e Forma: Red

Peso molecular: 563.98

Ref: TR-D194500

Daunorubicin HCl - Bio-X ™

CAS: 23541-50-6

Daunorubicin is an anthracycline antibiotic and antineoplastic agent that is used in the treatment of a variety of cancers such as nonlymphocytic leukemia and acute lymphocytic leukemia. The drug binds to DNA and inhibits transcription by intercalating between DNA base pairs and affecting the activity of the topoisomerase II enzyme and thus the gene expression. This results in apoptosis, mitochondrial injury, and finally cell death.

Fórmula: C₂₇H₂₉NO₁₀•HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 563.98 g/mol

Ref: 3D-BD164356

Daunorubicin HCl

CAS: 23541-50-6

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Fórmula: C₂₇H₂₉NO₁₀·HCl

Pureza: Min. 95%

Cor e Forma: Red Powder

Peso molecular: 563.98 g/mol

Ref: 3D-MD11679

Doxorubicin EP Impurity A

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀HCl

Peso molecular: 527.5 : 36.46

Ref: ST-EA-CP-D102001

Epirubicin EP Impurity D

CAS: 23541-50-6

Fórmula: C₂₇H₂₉NO₁₀HCl

Peso molecular: 527.53 : 36.46

Ref: ST-EA-CP-E117004