CAS 23583-48-4

8-Bromo-AMPc

Descrição:

8-Bromo-AMPc, com o número CAS 23583-48-4, é um derivado sintético do monofosfato de adenosina cíclico (cAMP), um mensageiro secundário crucial em vários processos biológicos. Este composto é caracterizado pela presença de um átomo de bromo na posição 8 do anel de adenina, o que melhora sua estabilidade e altera sua atividade biológica em comparação com o cAMP natural. 8-Bromo-AMPc é frequentemente utilizado em pesquisas bioquímicas para estudar as vias de transdução de sinal, particularmente aquelas que envolvem a proteína quinase A (PKA), pois pode imitar os efeitos do cAMP enquanto é resistente à degradação por fosfodiesterases. O composto é tipicamente solúvel em água e solventes orgânicos, tornando-o versátil para aplicações de laboratório. Sua capacidade de ativar a PKA e influenciar as respostas celulares o torna uma ferramenta valiosa em farmacologia e biologia celular. No entanto, como muitas substâncias químicas, deve ser manuseado com cuidado, seguindo os protocolos de segurança apropriados devido aos seus potenciais efeitos biológicos.

Fórmula: C₁₀H₁₁BrN₅O₆P

InChI: InChI=1/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1

Chave InChI: InChIKey=DVKQVRZMKBDMDH-UUOKFMHZSA-N

SMILES: BrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]

Sinónimos:

• (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 23583-48-4
• 3',5'-(Hidrogenofosfato) Ciclico De 8-Bromoadenosina
• 3',5'-(Hydrogenophosphate) Cyclique De 8-Bromoadenosine
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
• 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 8-Bromadenosin-cyclisch-3',5'-(hydrogenphosphat)
• 8-Bromo-cAMP
• 8-Bromo-cyclic 3',5'-AMP
• 8-Bromo-cyclic 3′,5′-AMP
• 8-Bromoadenosine Cyclic 3',5'-(Hydrogen Phosphate)
• 8-Bromoadenosine cyclic 3',5'-monophosphate
• 8-Bromoadenosine cyclic 3',5'-phosphate
• 8-Bromoadenosine cyclic 3′,5′-monophosphate
• 8-Bromoadenosine cyclic 3′,5′-phosphate
• 8-Bromoadenosine-cAMP
• Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate)
• Adenosine, 8-bromo-, cyclic 3′,5′-(hydrogen phosphate)
• Cyclic 8-bromoadenosine 3',5'-monophosphate
• Cyclic 8-bromoadenosine 3′,5′-monophosphate
• Nsc 171719
• 8-Bromo Cyclic Adenosine Monophosphate
• 8-BROMOADENOSINE-3-5-CYCLICMONOPHOSPHATE FREE ACID
• 8-Bromoadenosine 3',5'-monophosphate
• 8-Br-A-3:5-MP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE USP/EP/BP
• -CyclicMonophosphate
• 8-BR-CAMP
• 8-BROMOADENOSINE 3' 5'-CYCLIC
• 8-bromo-3',5'-cyclic AMP
• 8-BR-CAMP,98+%
• B-cAMP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE
• 8-Bromoadenosine 3',5'-phosphoric acid
• 8-Bromoadenosine-3'',-5''-cyclic monophosphoric acid
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE
• 8-Bromocyclic AMP
• 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE
• Cyclic amp, 8-bromo
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHORIC ACID

8-Bromoadenosine-3',5'-cyclic monophosphate

CAS: 23583-48-4

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₁₀H₁₁BrN₅O₆P

Peso molecular: 408.11

Ref: 02-J64469

8-Bromoadenosine cyclic 3',5'-monophosphate

CAS: 23583-48-4

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 408.1020

Ref: IN-DA002NRS

8-Bromoadenosine 3'',5''-cyclic monophosphate

CAS: 23583-48-4

Fórmula: C₁₀H₁₁BrN₅O₆P

Peso molecular: 408.11

Ref: 7W-GN1084

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP

Pureza: ≥95%

Peso molecular: 408.1g/mol

Ref: 54-OR1005158

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: 97.30%

Cor e Forma: Solid

Peso molecular: 408.1

Ref: TM-T35424

8-Bromoadenosine 3',5'-cyclic monophosphate

CAS: 23583-48-4

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: Min. 98 Area-%

Cor e Forma: Beige Powder

Peso molecular: 408.11 g/mol

Ref: 3D-NB07972

8-Bromo-cAMP

CAS: 23583-48-4

Pureza: 98%

Peso molecular: 406.96

Ref: 10-F554595