CAS 23651-95-8

Droxidopa

Descrição:

Droxidopa, com o número CAS 23651-95-8, é um análogo sintético do aminoácido da norepinefrina, utilizado principalmente como medicamento para tratar a hipotensão ortostática neurogênica. Funciona como um pró-fármaco, convertendo-se em norepinefrina no corpo, o que ajuda a aumentar a pressão arterial e melhorar o fluxo sanguíneo. A fórmula química de Droxidopa é C9H11NO4, e tem um peso molecular de aproximadamente 197,19 g/mol. Este composto é caracterizado por sua capacidade de atravessar a barreira hematoencefálica, tornando-o eficaz no tratamento de condições associadas à baixa pressão arterial devido à disfunção autonômica. Droxidopa é tipicamente administrado por via oral e é conhecido por seu perfil de segurança relativamente favorável, embora possa causar efeitos colaterais como dor de cabeça, náuseas e hipertensão. Sua farmacocinética envolve rápida absorção e metabolismo, com concentrações plasmáticas máximas ocorrendo dentro de algumas horas após a administração. No geral, Droxidopa representa uma opção terapêutica significativa para pacientes que sofrem de formas específicas de hipotensão ortostática.

Fórmula: C₉H₁₁NO₅

InChI: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

Chave InChI: InChIKey=QXWYKJLNLSIPIN-JGVFFNPUSA-N

SMILES: [C@@H]([C@@H](C(O)=O)N)(O)C1=CC(O)=C(O)C=C1

Sinónimos:

• (-)-threo-3,4-Dihydroxyphenylserine
• (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid
• (2S,3S)-2-ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
• (betaS)-beta,3-dihydroxy-D-tyrosine
• (βR)-β,3-Dihydroxy-<span class="text-smallcaps">L</span>-tyrosine
• <span class="text-smallcaps">L</span>-DOPS
• <span class="text-smallcaps">L</span>-Threodops
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, (βR)-
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, threo-
• <span class="text-smallcaps">L</span>-threo-3,4-Dihydroxyphenylserine
• <span class="text-smallcaps">L</span>-threo-3-(3,4-Dihydroxyphenyl)serine
• <span class="text-smallcaps">L</span>-threo-DOPS
• <span class="text-smallcaps">L</span>-threo-β-(3,4-Dihydroxyphenyl)serine
• Northera
• Serine, 3-(3,4-dihydroxyphenyl)-
• Serine, 3-(3,4-dihydroxyphenyl)-, <span class="text-smallcaps">L</span>-threo-
• Sm 5688
• Tyrosine, Beta,3-Dihydroxy-
• beta,3-Dihydroxytyrosine
• threo-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid
• threo-3-(3,4-Dihydroxyphenyl)-<span class="text-smallcaps">L</span>-serine
• threo-Dopaserine
• Serine, 3-(3,4-dihydroxyphenyl)-, L-threo-
• L-Tyrosine, β,3-dihydroxy-, (βR)-
• (βR)-β,3-Dihydroxy-L-tyrosine
• L-threo-3,4-Dihydroxyphenylserine

Droxidopa

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 213.19

Ref: 3B-D4235

Droxidopa

CAS: 23651-95-8

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Fórmula: C₉H₁₁NO₅

Cor e Forma: White Pale Yellow Powder

Peso molecular: 213.06372

Ref: 45-1229600

L-Tyrosine, β,3-dihydroxy-, (βR)-

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 213.1873

Ref: IN-DA002O25

Droxidopa

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Cor e Forma: Off-White Solid

Peso molecular: 213.19

Ref: 4Z-D-155003

Droxidopa (L-threo-3-(3,4-Dihydroxyphenyl)serine)

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Peso molecular: 213.19

Ref: 7W-GP7171

Droxidopa

CAS: 23651-95-8

Cor e Forma: Neat

Ref: 86-MM3786.00

Droxidopa

CAS: 23651-95-8

Droxidopa (L-DOPS), an oral prodrug, treats symptomatic orthostatic hypotension from neurogenic autonomic failure.

Fórmula: C₉H₁₁NO₅

Pureza: 97.27% - 99.88%

Cor e Forma: Solid

Peso molecular: 213.19

Ref: TM-T2547

L-threo-Droxidopa

Produto Controlado

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Cor e Forma: Neat

Peso molecular: 213.19

Ref: TR-D689960

Droxidopa

CAS: 23651-95-8

Pureza: 98%

Peso molecular: 213.1889954

Ref: 10-F787591

L-threo-Droxidopa-13C6

Produto Controlado

CAS: 23651-95-8

Fórmula: C₃C₆H₁₁NO₅

Cor e Forma: Neat

Peso molecular: 216.119

Ref: TR-D689963

L-threo-droxidopa

CAS: 23651-95-8

L-threo-droxidopa is a prodrug that is hydrolyzed in the liver to L-3,4-dihydroxyphenylalanine (L-DOPA) and then metabolized by dopamine β-hydroxylase to form dopamine. This drug has been shown to be effective for the treatment of Parkinson's disease. The long-term efficacy of this drug is unknown, but it has been shown to be safe and well tolerated for up to six months. L-threo-droxidopa has also been shown to be effective in lowering systolic blood pressure in patients with mild hypertension. The side effects of this drug include symptoms such as nausea, vomiting, dizziness, headache, and insomnia. However, these side effects are often transient and do not require discontinuation of treatment with this medication. There are no known interactions between L-threo-droxidopa and other drugs or foods. Pharmacological

Fórmula: C₉H₁₁NO₅

Pureza: Min. 95%

Cor e Forma: Off-White To Light (Or Pale) Beige Solid

Peso molecular: 213.19 g/mol

Ref: 3D-FT28252