CAS 2410-93-7

Metopterina

Descrição:

Metopterina, também conhecido como 4-amino-4-deóxi-N10-metilpteroylglutâmico, é um análogo do folato e um membro da classe de compostos antifolato. É reconhecido principalmente por seu papel como inibidor da diidrofolato redutase, uma enzima crítica na síntese de ácidos nucleicos. Metopterina é caracterizado por sua estrutura complexa, que inclui um anel de pteridina, um grupo de ácido para-aminobenzoico e uma cadeia lateral de ácido glutâmico. Este composto é frequentemente utilizado no tratamento de certos cânceres e doenças autoimunes devido à sua capacidade de interferir na proliferação celular. Metopterina é solúvel em água e apresenta um peso molecular relativamente baixo. Seus efeitos farmacológicos são atribuídos à sua capacidade de imitar o folato natural, interrompendo assim o metabolismo do folato em células que se dividem rapidamente. Embora tenha aplicações terapêuticas, Metopterina também pode levar a efeitos colaterais, exigindo monitoramento cuidadoso durante o tratamento. No geral, Metopterina serve como uma ferramenta importante na química médica, particularmente em oncologia e imunologia.

Fórmula: C₂₀H₂₁N₇O₆

InChI: InChI=1/C20H21N7O6/c1-27(9-11-8-22-16-15(23-11)18(31)26-20(21)25-16)12-4-2-10(3-5-12)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,8,13H,6-7,9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H3,21,22,25,26,31)

Chave InChI: InChIKey=HLIXOCXUWGDBNP-ZDUSSCGKSA-N

SMILES: O=C1C=2C(NC=C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)N2)=NC(N)=N1

Sinónimos:

• 10-Methylfolic acid
• 10-Methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
• Methopterin
• Methopterine
• N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)-methyl]methylamino]benzoyl]glutamic Acid
• N¹⁰-Methylfolic acid
• N¹⁰-Methylpteroylglutamic acid
• NSC 107144
• glutamic acid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, L-
• N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
• N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid
• N-(4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
• 2410-93-7
• Methotrexate Related Compound C (50 mg) ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzamido) pentanedioic acid)
• N10-MethylpteroylglutaMic Acid
• N10-Methylfolic acid
• Methotrexate-EP-Imp-C
• (2S)-2-[[4-[[(2-amino-4-hydroxy pteridin-6-yl) methyl] methyl amino] benzoyl] amino] pentanedioic acid
• N(10)-methylfolate
• Methotrexate Impurity 3(EP-C)
• benzoyl]glutaMic Acid
• N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid
• L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-
• Methotrexate imp C (Mono oxo imp)
• Methotrexate EP IMpurity C
• N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid
• Methotrexate EP Impurity C（Amethopterin EP Impurity C）
• N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]
• N-[p-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]- L-glutaMic Acid
• Methotrexate Impurity 3（Methotrexate EP Impurity C）
• Methotrexate Related CoMpound C
• N-[4-[[(2-AMino-1,4-dihydro-4-oxo-6-pteridinyl)
• 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
• Methyl]MethylaMino]benzoyl]-L-glutaMic Acid
• 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid
• N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

METHOTREXATE IMPURITY C CRS

CAS: 2410-93-7

METHOTREXATE IMPURITY C CRS

Ref: 41-Y0000663

Methotrexate Related Compound C ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzamido) pentanedioic acid)

CAS: 2410-93-7

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₂₀H₂₁N₇O₆

Cor e Forma: Dark Yellow Orange Powder

Peso molecular: 455.15533

Ref: 45-1414036

(S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 2410-93-7

(S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

Pureza: 98%

Peso molecular: 455.43g/mol

Ref: 54-OR1074673

Methopterin

CAS: 2410-93-7

Methopterin shows the activation and bone resorption function of murine osteoclasts.

Fórmula: C₂₀H₂₁N₇O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 455.43

Ref: TM-T20338

(2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic Acid (N-Methylfolic Acid, Methopterin)

Produto Controlado

CAS: 2410-93-7

Fórmula: C₂₀H₂₁N₇O₆

Cor e Forma: Neat

Peso molecular: 455.42

Ref: 86-MM0040.06

Methotrexate EP Impurity C (Methotrexate USP Related Compound C)

CAS: 2410-93-7

Fórmula: C₂₀H₂₁N₇O₆

Peso molecular: 455.43

Ref: 4Z-M-704

Methotrexate EP Impurity C

CAS: 2410-93-7

Fórmula: C₂₀H₂₁N₇O₆

Peso molecular: 455.43

Ref: ST-EA-CP-M12041

Methopterine (>90%)

Produto Controlado

CAS: 2410-93-7

Impurity Methotrexate EP Impurity C; Methotrexate USP Related Compound C
Applications Methopterine (Methotrexate EP Impurity C) is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy. Methotrexate USP Related Compound C
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),

Fórmula: C₂₀H₂₁N₇O₆

Pureza: >90%

Cor e Forma: Neat

Peso molecular: 455.42

Ref: TR-M305370

Methopterine-d3

Produto Controlado

CAS: 2410-93-7

Applications Labelled Methopterine (M305370). Methopterine is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy.
References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),

Fórmula: C₂₀H₁₈D₃N₇O₆

Cor e Forma: Neat

Peso molecular: 458.44

Ref: TR-M305372

Methotrexate Related Compound C

CAS: 2410-93-7

Methotrexate Related Compound C (MRCC) is a drug that binds to the folate receptor and inhibits the synthesis of purines, pyrimidines, and dNTPs. It can be used in the treatment of autoimmune diseases, cancer, and hyperproliferative diseases. MRCC is not effective against acute lymphoblastic leukemia or myelodysplastic syndrome. MRCC has been shown to have therapeutic effects on skin cancer cells in tissue culture by inhibiting their proliferation. The mechanism of action may be due to its ability to inhibit protein kinase C activity. MRCC has been shown to be an effective inhibitor of lipid kinase in vitro and in vivo.

Fórmula: C₂₀H₂₁N₇O₆

Pureza: Min. 95%

Peso molecular: 455.42 g/mol

Ref: 3D-CAA41093