CAS 24305-27-9

Hormônio liberador de tireotropina

Descrição:

A hormona liberadora de tirotropina (TRH), também conhecida como Hormônio liberador de tireotropina, é um hormônio tripeptídico composto por três aminoácidos: ácido pirrolidínico, histidina e prolina. Ela desempenha um papel crucial na regulação da função tireoidiana, estimulando a liberação do hormônio estimulante da tireoide (TSH) da glândula pituitária anterior. A TRH é sintetizada no hipotálamo e está envolvida no eixo hipotálamo-hipofisário-tireoide, influenciando processos metabólicos e a homeostase energética. O número CAS 24305-27-9 identifica especificamente este peptídeo, que geralmente é encontrado em forma sólida ou liofilizada para aplicações de pesquisa e terapêuticas. A TRH é solúvel em água e pode ser administrada por várias vias, incluindo injeção intravenosa ou subcutânea. Sua atividade biológica é mediada através de receptores específicos na glândula pituitária, levando a efeitos subsequentes na produção de hormônios tireoidianos. Além disso, a TRH tem sido estudada por seus potenciais papéis em várias condições fisiológicas e patológicas, incluindo seus efeitos sobre o humor e as respostas ao estresse.

Fórmula: C₁₆H₂₂N₆O₄

InChI: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

Chave InChI: InChIKey=XNSAINXGIQZQOO-SRVKXCTJSA-N

SMILES: C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3

Sinónimos:

• (Pyro)-<span class="text-smallcaps">L</smallcap>-glutamic acid-<smallcap>L</smallcap>-histidine-<smallcap>L</span>-proline-NH₂
• (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2
• 252: PN: WO2010033207 SEQID: 378 claimed protein
• 5-Oxo-<span class="text-smallcaps">L</smallcap>-prolyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• 83: PN: US20090175821 PAGE: 403 claimed protein
• <span class="text-smallcaps">L</smallcap>-Prolinamide, 5-oxo-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-histidyl-
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-proline amide
• Abbott 38579
• Antepan
• Fda 1725
• L-Pyroglutamyl-L-histidyl-L-prolinamide
• L-Pyroglutamyl-L-histidyl-L-proline amide
• Lopremone
• Prem
• Protirelin
• Protirelina
• Protireline
• Relefact TRH
• Rifathyroin
• Rifotironin
• Ro 8-6270/9
• Stimu TSH
• Synthetic TRF
• Synthetic TRH
• Synthetic TSH-releasing factor
• Synthetic TSH-releasing hormone
• Synthetic thyrotropin-releasing factor
• Synthetic thyrotropin-releasing hormone
• TRF
• TRH
• TSH-releasing factor
• TSH-releasing hormone
• Thypinone
• Thyrefact
• Thyroid releasing hormone
• Thyroid-stimulating hormone-releasing factor
• Thyroliberin
• Thyrotropic hormone-releasing factor
• Thyrotropic hormone-releasing hormone
• Thyrotropic releasing hormone
• Thyrotropic-releasing factor
• Thyrotropin-releasing factor
• Thyrotropin-releasing hormone
• Tsh-Rf
• L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-

Thyrotropin-Releasing Hormone

CAS: 24305-27-9

Thyrotropin-Releasing Hormone

Fórmula: C₁₆H₂₂N₆O₄

Cor e Forma: White, Lyophilized powder

Peso molecular: 362.38

Ref: 02-J62120

TRH

CAS: 24305-27-9

TRH exhibits a variety of biological effects, when injected into humans or animals. Its physiological role appears to be the stimulation of thyrotropin (TSH) and prolactin (PRL) release from the anterior pituitary. Though it was first identified in the hypothalamus as a regulator of the pituitary-thyroid axis, TRH was detected as well by Luo et al. in pancreatic β-cells co-localized with insulin. Application of the hormone reverted hyperglycemia in rats. Moreover, TRH plays an important role in the control of human hair-growth and hair follicle pigmentation.

Fórmula: C₁₆H₂₂N₆O₄

Pureza: 98.6%

Cor e Forma: Whitish Powder

Peso molecular: 362.39

Ref: 01-4038214

PROTIRELIN CRS

CAS: 24305-27-9

PROTIRELIN CRS

Fórmula: C₁₆H₂₂N₆O₄

Peso molecular: 362.3837

Ref: 41-P3760000

Protirelin

CAS: 24305-27-9

Protirelin

Pureza: ≥98%

Peso molecular: 362.38g/mol

Ref: 54-BUP06401

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

CAS: 24305-27-9

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

Pureza: 98%

Peso molecular: 362.38g/mol

Ref: 54-OR1026190

Thyrotropin releasing hormone

CAS: 24305-27-9

Fórmula: C₁₆H₂₂N₆O₄

Peso molecular: 362.38

Ref: 7W-GL4561

Protirelin

CAS: 24305-27-9

Fórmula: C₁₆H₂₂N₆O₄

Peso molecular: 362.39

Ref: 4Z-PP-357001

Protirelin

CAS: 24305-27-9

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

Fórmula: C₁₆H₂₂N₆O₄

Pureza: 99.76%

Cor e Forma: White Or Almost White Powder

Peso molecular: 362.38

Ref: TM-T6956

Protirelin

CAS: 24305-27-9

Cor e Forma: Neat

Ref: 86-MM3358.00

Protirelin

CAS: 24305-27-9

Fórmula: C₁₆H₂₂N₆O₄

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 362.38

Ref: BP-BPPG055

Thyrotropin-Releasing Hormone

Produto Controlado

CAS: 24305-27-9

Applications Thyrotropin-Releasing Hormone is a hypothalamic hypophysiotropic neuropeptide, which has the ability to stimulate the release of thyroid-stimulating hormone in mammals. It is proven that Thyrotropin-Releasing Hormone can be used to accelerate wound healing.
References Kanasaki, H., et al.: Neuropeptides., 54, 73 (2015); Nie, C., et al.: J. Surg. Res., 189, 364 (2014);

Fórmula: C₁₆H₂₂N₆O₄

Cor e Forma: Off-White

Peso molecular: 362.38

Ref: TR-T413510

L-Pyroglutamyl-L-histidyl-L-prolinamide

CAS: 24305-27-9

L-Pyroglutamyl-L-histidyl-L-prolinamide (PGC) is a pyrrolidine that is used for the treatment of neurologic disorders. It has been shown to be effective in treating depression and a number of other neurologic disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. PGC has also been shown to have an antidepressant effect in women with depression who are pregnant or have recently given birth. In addition, it has been found to be clinically effective in the treatment of symptoms associated with Parkinson’s Disease. PGC is not absorbed into the bloodstream and must be injected directly into muscle tissue or fat cells in order to produce its therapeutic effects.

Fórmula: C₁₆H₂₂N₆O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 362.38 g/mol

Ref: 3D-FP33965

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS: 24305-27-9

Thyrotropin releasing hormone (TRH) is a peptide that is produced in the hypothalamus. It has various functions, including being an activator of thyroid stimulating hormone (TSH) and releasing growth hormone from the anterior pituitary gland. TRH also has anti-inflammatory effects and is used as a research tool in cell biology. TRH binds to receptors on cells and can activate ion channels, which causes an influx of calcium ions into cells. This leads to the activation of protein kinases, which are important in cell signaling pathways. TRH also interacts with other proteins, such as receptor tyrosine kinases and G-protein coupled receptors.

Fórmula: C₁₆H₂₂N₆O₄

Pureza: Min. 95%

Peso molecular: 362.38 g/mol

Ref: 3D-PTR-4011-V

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS: 24305-27-9

Thyrotropin Releasing Hormone (TRH) is a hormone that stimulates the release of thyroid hormones. TRH has been used to diagnose and treat conditions such as autoimmune diseases, infectious diseases, and thyroid disease. It is also used in the treatment of patients with hypothyroidism who are not responding to levothyroxine therapy. TRH is administered intravenously or intramuscularly. This drug is primarily used for diagnostic purposes in women who have symptoms of hyperthyroidism but normal serum levels of TSH and thyroxine levels. TRH administration can result in a rise in serum prolactin levels, which may be useful for diagnosis of the condition hyperprolactinemia.

Fórmula: C₁₆H₂₂N₆O₄•H₂O

Pureza: Min. 95%

Peso molecular: 380.4 g/mol

Ref: 3D-PTR-4011