CAS 24346-00-7

Cloreto de S-Adenosil-L-metionina

Descrição:

Cloreto de S-Adenosil-L-metionina (SAMe) é um composto que ocorre naturalmente e desempenha um papel crucial em vários processos biológicos, particularmente em reações de metilação. É um composto sulfonio derivado do aminoácido metionina e do trifosfato de adenosina (ATP). SAMe é caracterizado por sua capacidade de doar grupos metila a uma variedade de substratos, incluindo DNA, proteínas e lipídios, o que é essencial para a regulação da expressão gênica e a manutenção da função celular. A forma de cloreto indica a presença de um íon cloreto associado à molécula, o que pode influenciar sua solubilidade e estabilidade. SAMe é solúvel em água e apresenta um pH neutro a ligeiramente básico em solução. É frequentemente utilizado em ambientes clínicos por seus potenciais efeitos terapêuticos, incluindo a melhoria do humor e o suporte à saúde do fígado. Além disso, SAMe está envolvido na síntese de biomoléculas importantes, como neurotransmissores e fosfolipídios, destacando sua importância tanto em funções metabólicas quanto neurológicas.

Fórmula: C₁₅H₂₃ClN₆O₅S

InChI: InChI=1/C15H22N6O5S.ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7?,8-,10-,11-,14-,27?;/m1./s1

Chave InChI: InChIKey=DYFPQIYEZQULMZ-XKGORWRGSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C[S+](CC[C@@H](C(O)=O)N)C)[C@H]1O.[Cl-]

Sinónimos:

• (3-amino-3-carboxypropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium chloride (non-preferred name)
• (3S)-5'-((3-Amino-3-carboxypropyl)methylsulphonio)-5'-deoxyadenosine chloride
• <span class="text-smallcaps">L</span>-Methionine, adenosine deriv.
• Adenosine, 5′-[(3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, chloride
• Adenosine, 5′-[(3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, chloride, (3S)-
• Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, chloride
• Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, chloride (1:1)
• Methionine, S-(5-deoxyadenos-5-yl)-, chloride, <span class="text-smallcaps">L</span>-
• S-(5-Adenosyl)-<span class="text-smallcaps">L</span>-methionine chloride
• S-Adenosyl-<span class="text-smallcaps">L</span>-methionine chloride
• S-Adenosylmethionine chloride
• [(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium chloride (non-preferred name)
• Methionine, S-(5-deoxyadenos-5-yl)-, chloride, L-
• Einecs 246-184-8
• S-ADENOSYL-L-METHIONINE CHLORIDE
• 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine chloride
• S-(5'-ADENOSYL)-L-METHIONINE CHLORIDE
• S-(5′-Adenosyl)-L-methionine chloride,Active methionine, AdoMet, SAM chloride
• SAM CHLORIDE
• ACTIVE METHIONINE
• Active methionine chloride
• ADENOSYL-L-METHIONINE CHLORIDE, S-(RG)
• S-ADENOSYL-L-METHIONINE CHLORIDE SALT USP/EP/BP
• S-Adenosyl-5'-L-methionine chloride
• S-ADENOSYL METHIONINE CHLORIDE SALT
• ((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium chloride
• SAM-Cl
• ADEMETHIONINECHLORIDE
• S-Adenosyl-5'-L-MethionineChlorideEx
• S-ADENOSYL-L-METHIONINE CHLORIDE SALT
• ADENOSYL-L-METHIONINE, S-CHLORIDE SALT
• (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfaniumyl)butanoate hydrochloride
• SAM-E CHLORIDE SALT

5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine chloride

CAS: 24346-00-7

Fórmula: C₁₅H₂₃ClN₆O₅S

Peso molecular: 434.8983

Ref: IN-DA00BDS8

S-(5'-Adenosyl)-L-methionine-13C5 Sulfate Salt (Synthetic)(Mixture of Diastereomers)

Produto Controlado

CAS: 24346-00-7

Stability Hygroscopic
Applications Labelled S-(5'-Adenosyl)-L-methionine Disulfate Salt (A291530). Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
References Friedel, H., et al.: Drugs, 38, 389 (1989), Lu, S., et al.: Int. J. Biochem. Cell Biol., 32, 391 (2000), Amin, K., et al.: Pharm. Res., 18, 914 (2001),

Fórmula: C₁₀₁₃C₅H₂₃N₆O₅S•HSO₄•xH₂SO₄

Pureza: >85%

Cor e Forma: Neat

Peso molecular: 404.4197079808

Ref: TR-A291533

S-(5'-Adenosyl)-L-methionine Disulfate Salt (Synthetic) (Mixture of Diastereomers)

CAS: 24346-00-7, 485-80-3

Stability Hygroscopic
Applications Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
References Friedel, H., et al.: Drugs, 38, 389 (1989), Lu, S., et al.: Int. J. Biochem. Cell Biol., 32, 391 (2000), Amin, K., et al.: Pharm. Res., 18, 914 (2001),

Fórmula: C₁₅H₂₆N₆O₁₃S

Pureza: >85%

Cor e Forma: Neat

Peso molecular: 594.59

Ref: TR-A291530