CAS 2436-17-1

5-Metoxi-3-indolilacetonitrila

Descrição:

5-Metoxi-3-indolilacetonitrila, com o número CAS 2436-17-1, é um composto químico que apresenta uma estrutura de indol, que é um composto bicíclico consistindo em um anel de benzeno fundido a um anel de pirrol. Este composto é caracterizado pela presença de um grupo metóxi (-OCH3) na posição 5 do anel de indol e um grupo acetonitrilo (-C≡N) na posição 3. O grupo metóxi contribui para a polaridade do composto e pode influenciar sua reatividade e solubilidade em vários solventes. A parte de acetonitrilo introduz um grupo funcional nitrilo, que é conhecido por sua capacidade de participar de reações nucleofílicas e pode servir como um bloco de construção versátil na síntese orgânica. 5-Metoxi-3-indolilacetonitrila pode exibir atividade biológica, tornando-o de interesse na química medicinal e farmacologia. Suas propriedades, como ponto de fusão, ponto de ebulição e solubilidade, podem variar com base nas condições específicas e na pureza da amostra.

Fórmula: C₁₁H₁₀N₂O

InChI: InChI=1/C11H10N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4H2,1H3

SMILES: COc1ccc2c(c1)c(CC#N)c[nH]2

Sinónimos:

• 5-Methoxyindole-3-acetonitrile
• (5-methoxy-1H-indol-3-yl)acetonitrile

2-(5-methoxy-1H-indol-3-yl)acetonitrile

CAS: 2436-17-1

Fórmula: C₁₁H₁₀N₂O

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 186.2099

Ref: IN-DA006W7A

5-Methoxyindole-3-acetonitrile

CAS: 2436-17-1

Ref: 7W-GK1206

(5-Methoxy-1H-indol-3-yl)acetonitrile

CAS: 2436-17-1

(5-Methoxy-1H-indol-3-yl)acetonitrile

Pureza: ≥95%

Cor e Forma: Beige Solid

Peso molecular: 186.21g/mol

Ref: 54-OR8748

5-Methoxyindole-3-acetonitrile

CAS: 2436-17-1

5-Methoxyindole-3-acetonitrile is a synthetic compound used as a reference for the synthesis of melatonin. It is produced by the addition of magnesium to 5-methoxyindole, followed by reaction with cyanide and nitrile. The synthesis of this compound was first published in 1938 and has since been used as a reference for many other studies. It has been shown that 5-methoxyindole-3-acetonitrile has high performance liquid chromatography properties, with a linear range from 0.5 to 50 mg/mL and an ultraviolet spectrum that falls within the region between 220 nm and 400 nm. A molecular modeling study was conducted on this compound, which showed that it conforms with 4-hydroxy indole ring systems found in natural products such as tryptophan and serotonin. This product also has fluorescent properties, which are caused by its electron withdrawing group (cyano).

Fórmula: C₁₁H₁₀N₂O

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 186.21 g/mol

Ref: 3D-FM38506

5-Methoxyindole-3-acetonitrile-d2

Produto Controlado

CAS: 2436-17-1

Applications 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen re
References Barchas, et al.: Nature, 214, 919 (1967); Glass, J.D., et al.: Science, 214, 821 (1981)

Fórmula: C₁₁D₂H₈N₂O

Cor e Forma: Neat

Peso molecular: 188.222

Ref: TR-M262819

5-METHOXYINDOLE-3-ACETONITRILE

CAS: 2436-17-1

Fórmula: C₁₁H₁₀N₂O

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 186.214

Ref: 10-F386808

5-Methoxyindole-3-acetonitrile

Produto Controlado

CAS: 2436-17-1

Applications 5-Methoxyindole-3-acetonitrile is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors.
References Van Zandt, M., et al.: J. Med. Chem., 48, 3141 (2005); Wu, J., et al.: Bioorg. Med. Chem. Lett., 17, 4664 (2007);

Fórmula: C₁₁H₁₀N₂O

Cor e Forma: Neat

Peso molecular: 186.21

Ref: TR-M262818

5-Methoxyindole-3-acetonitrile

CAS: 2436-17-1

5-Methoxyindole-3-acetonitrile is a versatile building block that can be used for the synthesis of complex compounds. It is a fine chemical that is not commercially available and is sold at high prices as a research chemical. 5-Methoxyindole-3-acetonitrile has been used as a reagent in the synthesis of some pharmaceuticals, such as beta blockers. This compound also has been researched for its potential use as an intermediate in organic syntheses and reactions, including those involving peptides and proteins. The versatility of this chemical makes it useful for the construction of new molecules with medicinal properties.

Fórmula: C₁₁H₁₀N₂O

Peso molecular: 186.22 g/mol

Ref: 3D-M-3480

Melatonin Impurity 1

CAS: 2436-17-1

Fórmula: C₁₁H₁₀N₂O

Peso molecular: 186.21

Ref: ST-EA-CP-M166004