CAS 24390-14-5

Doxiciclina hiclato

Descrição:

Doxiciclina hiclato é um antibiótico de amplo espectro pertencente à classe das tetraciclinas, usado principalmente para tratar várias infecções bacterianas, incluindo infecções do trato respiratório, infecções do trato urinário e certas condições de pele. É caracterizado pela sua capacidade de inibir a síntese de proteínas nas bactérias, ligando-se à subunidade ribossomal 30S, impedindo assim o crescimento e a reprodução dos microrganismos. Doxiciclina hiclato é um derivado semissintético da tetraciclina, que melhora sua estabilidade e absorção no trato gastrointestinal. A substância é tipicamente administrada por via oral e é conhecida por sua meia-vida relativamente longa, permitindo a dosagem uma ou duas vezes ao dia. Também é eficaz contra certas infecções protozoárias e é usada no tratamento da acne e como profilaxia para a malária. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais, fotossensibilidade e efeitos potenciais no desenvolvimento de ossos e dentes em crianças. Devido à sua ampla atividade, Doxiciclina hiclato é uma ferramenta valiosa tanto na medicina humana quanto veterinária.

Fórmula: C₂₂H₂₄N₂O₈C₂H₆O·ClHH₂O

InChI: InChI=1S/C22H24N2O8.C2H6O.ClH.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;1H;1H2/t7-,10+,14+,15-,17-,22-;;;/m0.../s1

Chave InChI: InChIKey=JRNIHERUNQWMMW-WBYAVNBMSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H].Cl.C(C)O.O

Sinónimos:

• (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
• (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione - ethanol (2:1) dihydrochloride hydrate
• (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione - ethanol (2:1) dihydrochloride hydrate
• (4S,4Ar,5S,5Ar,6R,12As)-4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide Hydrochloride
• (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide-ethanol hydrochloride hydrate (2:1:2:1)
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5α,5aα,6α,12aα)]-, compd. with ethanol (2:1), monohydrate
• 2-Naphthacenecarboxamide, 4β-(dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6β-methyl-1,11-dioxo-, monohydrochloride, compd. with ethyl alc. (2:1), monohydrate
• 4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Na
• 4-(Dimethylamino)-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide
• 4-(Dimethylamino)-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide-Ethanol (2:1) Dihydrochloride Hydrate
• 6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate
• Atridox
• BioPure MTAD
• Doryx
• Dox-T 100
• Doxitrat
• Doxy 100
• Doxycycline Hyclate
• Doxycycline Hyclate Monohydrate
• Doxycycline Hydrate
• Doxycycline Hydrochlocide
• Doxycycline Hydrochloride
• Doxycycline Hydrochloride Anhydrous
• Doxycycline Hydrochloride Hemiethanolate Hemihydrate
• Doxycycline hyclate COS
• Doxyprex
• Ethanol, compd. with (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate
• Ethanol, compd. with [4S-(4α,4aα,5α,5aα,6α,12aα)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate
• Monodoks
• Periostat
• Tetraclean

Doxycycline Hyclate

CAS: 10592-13-9, 24390-14-5, 564-25-0

Fórmula: C₂₂H₂₄N₂O₈C₂H₆O·HClH₂O

Pureza: >97.0%(HPLC)

Cor e Forma: Light yellow to Amber to Dark green powder to crystal

Peso molecular: 512.94

Ref: 3B-D4116

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate, 24390-14-5, is an antibiotic which inhibits bacterial growth by preventing polypeptide formation. Learn more at Thermo Fisher Scientific.

Fórmula: C₄₆H₅₈Cl₂N₄O₁₈

Cor e Forma: Powder or crystals or crystalline powder, Yellow

Peso molecular: 1025.88

Ref: 02-J60579

DOXYCYCLINE HYCLATE CRS

CAS: 24390-14-5

DOXYCYCLINE HYCLATE CRS

Fórmula: C₄₆H₅₈Cl₂N₄O₁₈

Cor e Forma: Crystalline Powder. Yellow. Powder.

Peso molecular: 1025.875

Ref: 41-D3000000

DOXYCYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 24390-14-5

DOXYCYCLINE FOR SYSTEM SUITABILITY CRS

Fórmula: C₄₆H₅₈Cl₂N₄O₁₈

Cor e Forma: Crystalline Powder. Yellow. Powder.

Peso molecular: 1025.875

Ref: 41-Y0001714

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate

Fórmula: C₂₂H₂₄N₂O₈ / C₂₂H₂₅ClN₂O₈

Pureza: 83.1% / 89.9%

Cor e Forma: Yellow

Peso molecular: 444.15327 / 480.12994

Ref: 47-780

Doxycycline Hyclate

CAS: 24390-14-5

Tetracyclines and their derivatives; salts thereof

Fórmula: C₁₂H₂₄N₂O₈C₂H₆O·ClHH₂O

Cor e Forma: Light Yellow Powder

Peso molecular: 1025.89

Ref: 45-1226003

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)

CAS: 24390-14-5

Fórmula: C₄₆H₅₈Cl₂N₄O₁₈

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 1025.8747

Ref: IN-DA0034T4

Doxycycline (hyclate)

CAS: 24390-14-5

Doxycycline (hyclate)

Pureza: ≥95%

Peso molecular: 512.9g/mol

Ref: 54-BUP17418

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate

Pureza: 99%

Peso molecular: 544.982g/mol

Ref: 54-BI12151

Doxycycline hyclate

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈·HCl·5H₂O·5C₂H₆O

Pureza: 95.0 - 102.0 % (C22H25ClN2O8, anhydrous and ethanol free basis)

Cor e Forma: Yellow, crystalline powder, hygroscopic

Peso molecular: 512.94

Ref: 7W-GA1726

Doxycycline Hyclate

CAS: 24390-14-5

Cor e Forma: Neat

Ref: 61-FOR0276.00

Doxycycline hyclate 100 µg/mL in Acetonitrile

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Cor e Forma: Single Solution

Peso molecular: 1025.87

Ref: 04-A13084280AL-100

Doxycycline hyclate

Produto Controlado

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Cor e Forma: Neat

Peso molecular: 1025.87

Ref: 04-C13084280

PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol

Produto Controlado

CAS: 101342-45-4, 14206-58-7, 179471-95-5, 2058-46-0, 23313-80-6, 24390-14-5, 41411-66-9, 64-72-2, 64-73-3, 64-75-5

Cor e Forma: Mixture

Ref: 04-A30000035ME

Doxycycline Hyclate

Produto Controlado

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Cor e Forma: Neat

Peso molecular: 1025.87

Ref: 86-MM0276.00

Doxycycline (hyclate)

CAS: 24390-14-5

Doxycycline hyclate (WC2031) is a synthetic tetracycline derivative with similar antimicrobial activity. Doxycycline hyclate is also an inhibitor of MMP.

Fórmula: C₂₂H₂₄N₂O₈·HClC₂H₆OH₂O

Pureza: 97.48% - >99.99%

Cor e Forma: Yellow Crystallien Powder

Peso molecular: 512.90

Ref: TM-T1687L

Doxycycline Hyclate

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈(C₂H₆O)HCl(H₂O)

Peso molecular: 444.44 : 1/2(46.07) : 36.5 : 1/2(18.0)

Ref: ST-EA-CP-D56008

Doxycycline Hyclate

Produto Controlado

CAS: 24390-14-5

Applications Antibacterial.
References Fabre, et al.: Chemotherapia, 11, 73 (1966), Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Polson, A.M., et al.: J. Periodontol., 68, 110 (1997),

Fórmula: C₂₂H₂₄N₂O₈·C₂H₆O·2ClH·H₂O

Cor e Forma: Yellow

Peso molecular: 1025.87

Ref: TR-D561500

Doxycycline-d3 Hyclate (Major)

Produto Controlado

CAS: 24390-14-5

Applications Doxycycline-d3 Hyclate, is the labeled analogue of Doxycycline Hyclate (D561500), acting as an Antibacterial.
References Fabre, et al.: Chemotherapia, 11, 73 (1966), Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Polson, A.M., et al.: J. Periodontol., 68, 110 (1997),

Fórmula: (C₂₂H₂₁D₃N₂O₈)•2HCl•xH₂O•C₂H₆O

Cor e Forma: Neat

Peso molecular: 2447.452364618

Ref: TR-D561503

Doxycycline hyclate - Bio-X ™

CAS: 24390-14-5

Doxycycline is a tetracycline antibiotic that is used to treat a range of bacterial infections. It is a broad-spectrum antibiotic. This drug inhibits bacterial protein synthesis by binding to its 30S prokaryotic ribosomal subunit. It also inhibits the production of essential proteins required for the bacterial to survive.

Fórmula: C₂₂H₂₄N₂O₈•HCl•(C₂H₆O)₀•(H₂O)₀

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 512.94 g/mol

Ref: 3D-BD166236

Doxycycline hyclate

CAS: 24390-14-5

Antibiotic; anti-protozoal; anti-helmintic; protein synthesis inhibitor

Fórmula: C₂₂H₂₄N₂O₈•HCl•(C₂H₆O)₀•(H₂O)₀

Pureza: Min. 95 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 512.94 g/mol

Ref: 3D-AA22608

Doxycycline Hyclate (DXH), 800U/mg

CAS: 24390-14-5

Fórmula: C₂₂H₂₄N₂O₈·HClH₂OC₂H₆O

Cor e Forma: Yellow, Hygroscopic crystalline powder

Peso molecular: 512.94

Ref: SR-65094

Doxycycline hydrochloride hemiethanolate hemihydrate, Antibiotic for Culture Media Use Only

CAS: 24390-14-5

Doxycycline is an antibiotic that inhibits bacterial growth by inhibiting protein synthesis, respiratory chain, DNA gyrase, DNA topoisomerase IV. Doxycycline inhibits papaverine by blocking the expression of both cytochrome P450 and epoxide hydrolase. Doxycycline is commonly found in studies for bacterial infections, drug therapy, histopathological studies, cell culture and chemometric analysis.

Fórmula: C₂₂H₂₄N₂O₈·HClH₂OC₂H₆O

Pureza: Min. 97.0 Area-%

Peso molecular: 512.90 g/mol

Ref: 3D-Q-201047