CAS 2457-80-9

5′-(Metiltio)adenosina

Descrição:

5′-(Metiltio)adenosina, também conhecido como MTA, é um composto que ocorre naturalmente e desempenha um papel significativo em vários processos biológicos. É um derivado da adenosina, onde um grupo metiltio está ligado à posição 5' do açúcar ribose. O MTA é caracterizado por seu envolvimento na sinalização celular e no metabolismo, particularmente no contexto do metabolismo de purinas e como um potencial modulador das funções celulares. Ele exibe propriedades como ser um substrato para várias enzimas e ter implicações na regulação das respostas imunológicas e da inflamação. O MTA também é conhecido por seu papel na síntese de poliaminas, que são essenciais para o crescimento e diferenciação celular. Em termos de solubilidade, geralmente é solúvel em água e solventes polares, tornando-o acessível para várias aplicações bioquímicas. Seu número CAS, 2457-80-9, é usado para identificação em bancos de dados químicos e contextos regulatórios. No geral, 5′-(Metiltio)adenosina é um composto de interesse tanto na pesquisa bioquímica quanto em potenciais aplicações terapêuticas.

Fórmula: C₁₁H₁₅N₅O₃S

InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

Chave InChI: InChIKey=WUUGFSXJNOTRMR-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CSC)[C@H]1O

Sinónimos:

• 5'-(Methylthio)adenosine
• 5'-Deoxy-5'-Methylthioadenosine
• 5'-Methylthioadenosine
• 5'-S-Methyl-5'-thioadenosine
• 5'-S-Methylthioadenosine
• 5′-(Methylthio)-5′-deoxyadenosine
• 5′-Deoxy(methylthio)adenosine
• 9-(5-S-methyl-5-thiopentofuranosyl)-9H-purin-6-amine
• Adenosine, 5'-S-methyl-5'-thio-
• Brn 0042420
• Methylthioadenosine
• Nsc 335422
• Vitamin L(sub 2)
• Vitamin L2
• Vitamin L₂
• β-<span class="text-smallcaps">D</span>-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
• 4-26-00-03675 (Beilstein Handbook Reference)

Adenosine, 5'-S-methyl-5'-thio-

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 297.3335

Ref: IN-DA002OLP

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine

Pureza: ≥98%

Peso molecular: 297.33g/mol

Ref: 54-BUP14383

5’-Methylthioadenosine

CAS: 2457-80-9

5’-Methylthioadenosine

Pureza: 98%

Peso molecular: 297.33g/mol

Ref: 54-OR1011792

5''-Deoxy-5''-(methylthio)adenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Peso molecular: 297.33

Ref: 7W-GN7022

Adenosyl Methionine Impurity 1

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Cor e Forma: White To Off-White Solid

Peso molecular: 297.33

Ref: 4Z-A-106029

5'-Deoxy-5'-methylthioadenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: >95.0%(T)(HPLC)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 297.33

Ref: 3B-M3801

5'-S-Methyl-5'-thioadenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 95%~99%

Cor e Forma: Powder

Peso molecular: 297.333

Ref: BP-SBP01153

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 99.32% - 99.34%

Cor e Forma: Solid

Peso molecular: 297.33

Ref: TM-T8227

Adenosyl Methionine Impurity 1-13C5

CAS: 2457-80-9

Fórmula: C₆₁₃C₅H₁₅N₅O₃S

Peso molecular: 302.29

Ref: 4Z-A-106046

5'-Deoxy-5'-(methylthio)adenosine-d3

Produto Controlado

CAS: 2457-80-9

Applications Labelled 5'-Deoxy-5'-(methylthio)adenosine (D242600). 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: C₁₁H₁₂D₃N₅O₃S

Cor e Forma: Neat

Peso molecular: 300.35

Ref: TR-D242602

5'-Deoxy-5'-(methylthio)adenosine-13C

Produto Controlado

CAS: 2457-80-9

Applications A Labelled isotope of 5'-Deoxy-5'-(methylthio)adenosine (D242600) which is used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28)
References Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: CC₁₀H₁₅N₅O₃S

Cor e Forma: Neat

Peso molecular: 298.326

Ref: TR-D242604

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: C₁₁H₁₅N₅O₃S

Cor e Forma: White To Off-White

Peso molecular: 297.33

Ref: TR-D242600

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

5'-Deoxy-5'-(methylthio)adenosine is a nucleoside that has been shown to inhibit the growth of bowel cancer cells. 5'-Deoxy-5'-(methylthio)adenosine blocks the synthesis of DNA and RNA by inhibiting the action of enzymes involved in DNA metabolism. It also inhibits methionine synthase and phosphorylase, which are involved in protein synthesis. This compound has been shown to be effective in treating cancer tissues due to its ability to inhibit polymerase chain reactions and prevent the formation of cancerous cells.

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: (Hplc-Ms) Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 297.34 g/mol

Ref: 3D-ND07992

(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 96%

Peso molecular: 297.33

Ref: 10-F230436

5'-Deoxy-5'-(methylthio)adenosine-15N5

Produto Controlado

CAS: 2457-80-9

Fórmula: C₁₁H₁₅₁₅N₅O₃S

Cor e Forma: Neat

Peso molecular: 302.3

Ref: TR-D242603

5’-Deoxy-5’-(methylthio)adenosine

Produto Controlado

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Cor e Forma: Neat

Peso molecular: 297.33

Ref: TR-D232740

5\'-Deoxy-5\'-(methylthio)adenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Peso molecular: 297.33

Ref: ST-EA-CP-A88010