CAS 24730-10-7

Mesilato de diidroergocristina

Descrição:

Mesilato de diidroergocristina é um derivado semissintético de alcaloides do ergot, utilizado principalmente em aplicações farmacológicas. É caracterizado por sua capacidade de atuar como vasodilatador e tem sido estudado por seus potenciais efeitos neuroprotetores. O composto é tipicamente apresentado como um sal mesilato, que melhora sua solubilidade e estabilidade em várias formulações. Mesilato de diidroergocristina exibe uma estrutura complexa, com múltiplos centros quirais, o que contribui para sua atividade biológica. Sabe-se que interage com receptores adrenérgicos e serotoninérgicos, influenciando a liberação de neurotransmissores e o tônus vascular. A substância é frequentemente utilizada no tratamento de condições como distúrbios vasculares periféricos e declínio cognitivo associado ao envelhecimento. Os perfis de segurança e eficácia são estabelecidos por meio de estudos clínicos, embora os efeitos colaterais possam incluir distúrbios gastrointestinais e efeitos cardiovasculares. Assim como muitos agentes farmacológicos, seu uso deve ser monitorado por profissionais de saúde para mitigar possíveis reações adversas.

Fórmula: C₃₆H₄₅N₅O₈S

InChI: InChI=1/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1

Chave InChI: InChIKey=SPXACGZWWVIDGR-SPZWACKZSA-N

SMILES: O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@@H]5C[C@@]6(C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)[H])(C(C)C)O2.S(C)(=O)(=O)O

Sinónimos:

• (5'Alpha,10Alpha)-5'-Benzyl-12'-Hydroxy-3',6',18-Trioxo-2'-(Propan-2-Yl)-9,10-Dihydroergotaman Methanesulfonate (1:1)
• 5'alpha-Benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
• 9,10-Dihydroergocristine methanesulfonate
• Dihydroergocristine methanesulfonate
• Dihydroergocristinmesilat
• Dihydroergocristinmesilat [German]
• Ergocristine, 9,10-dihydro-, monomethanesulfonate (salt)
• Ergocristine, dihydro-, methanesulfonate
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, monomethanesulfonate (salt)
• Ergotamane-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'-alpha,10-alpha)-, monomethanesulfonate (salt)
• GNF Pf 3462
• Unii-Ds7Cl18Uam
• Dihydroergocristine mesylate
• DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID, VASOC
• ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
• (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
• (5,10a)-9,10-Dihydro-12hydroxy-2(1-methylethyl)-5(phenylmethyl)-ergotamane-3618-trionemesylate]
• (5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate
• DIHYDROERGOCRYSTINE METHANESULFONATE SALT
• Dihydroergocristine mesilate (D1945000)
• (5'A,10A)-9,10-DIHYDRO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(PHENYLMETHYL)-ERGOTAMAN-3',6',18-TRIONE MESYLATE
• Dihydroergocristine mesilate CRS
• 9,10-dihydro-ergocristinmonomethanesulfonate(salt)
• (5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt)
• dihydroergocristine methanesulfonate salt
• C13168
• Dihydroergotamine Mesilate Impurity E as Mesilate
• Dihydroergotamine Mesilate EP Impurity E as Mesilate

Dihydroergocristine methanesulfonate

CAS: 24730-10-7

5-HT receptor antagonist; partial agonist at adrenergic and dopaminergic receptors

Fórmula: C₃₆H₄₅N₅O₈S

Cor e Forma: White, Powder or crystals or crystalline powder

Peso molecular: 707.84

Ref: 02-J60638

DIHYDROERGOCRISTINE MESILATE CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE CRS

Fórmula: C₃₆H₄₅N₅O₈S

Peso molecular: 707.8362

Ref: 41-D1945000

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

Ref: 41-Y0002323

Dihydroergocristine (mesylate)

CAS: 24730-10-7

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: 99.86%

Cor e Forma: Solid

Peso molecular: 707.8362

Ref: IN-DA002P9C

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine mesylate

Pureza: ≥98%

Peso molecular: 707.84g/mol

Ref: 54-BUP12047

Dihydroergocristine Mesilate

Produto Controlado

CAS: 24730-10-7

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 707.84

Ref: 86-MM1812.00

Dihydroergocristine mesylate

CAS: 24730-10-7

DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: 98.9% - 99.79%

Cor e Forma: Solid

Peso molecular: 707.84

Ref: TM-T11043

9,10-Dihydroergocristine Methanesulfonate

CAS: 24730-10-7

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Peso molecular: 611.74 96.10

Ref: 4Z-E-088005

Dihydroergocristine Mesylate

CAS: 24730-10-7

Dihydroergocristine Mesylate

Peso molecular: 707.84g/mol

Ref: 54-BID1021

9,10-Dihydroergocristine Methanesulfonate

Produto Controlado

CAS: 24730-10-7

Applications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.
References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 707.84

Ref: TR-D446440

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine is an anti-hypertensive drug that belongs to the class of pharmacological agents. It is used for the treatment of high blood pressure and has been shown to reduce the risk of stroke in patients with cerebrovascular disease. Dihydroergocristine has been found to inhibit the production of 5-hydroxytryptamine (5-HT) by binding to serotonin receptors in vitro, although its effects on human serum levels have not been determined. This drug also inhibits certain enzymes, such as energy metabolism and protein synthesis. Dihydroergocristine can be administered in a solution or as an injection, depending on the severity of symptoms.

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: Min. 95%

Cor e Forma: Solid

Peso molecular: 707.84 g/mol

Ref: 3D-FD39334

Dihydroergocristine mesilate

CAS: 24730-10-7

Dihydroergocristine mesilate

Cor e Forma: White Solid

Ref: 47-120