CAS 24939-03-5

Poli(I:C)

Descrição:

Poli(I:C), ou ácido poliinossínico-policitídico, é uma molécula sintética de RNA de dupla fita que atua como um potente imunostimulante. É reconhecido principalmente por seu papel em mimetizar infecções virais, ativando assim a resposta imunológica, particularmente através da estimulação dos receptores tipo Toll (TLRs), especificamente TLR3. Essa ativação leva à produção de várias citocinas e interferons, melhorando as defesas antivirais do corpo. Poli(I:C) é frequentemente utilizado em pesquisas e aplicações terapêuticas, incluindo o desenvolvimento de vacinas e imunoterapia contra o câncer, devido à sua capacidade de induzir uma resposta imunológica robusta. A substância é tipicamente caracterizada por seu alto peso molecular e é solúvel em água, tornando-a adequada para vários ensaios biológicos. Além disso, Poli(I:C) pode ser modificado para melhorar sua estabilidade e eficácia, como por meio da incorporação de modificações químicas que aumentam sua resistência à degradação por nucleases. No geral, Poli(I:C) é uma ferramenta valiosa em imunologia e pesquisa terapêutica, contribuindo para nossa compreensão dos mecanismos imunológicos e das estratégias de tratamento potenciais.

Fórmula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

InChI: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

Chave InChI: InChIKey=ACEVNMQDUCOKHT-ZLOOHWKQSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](COP(=O)(O)O)[C@H]1O.O[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)N2C(=O)N=C(N)C=C2

Sinónimos:

• 4-amino-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one - 9-(5-O-phosphonopentofuranosyl)-3,9-dihydro-6H-purin-6-one (1:1)
• 5'-Cytidylic Acid - 5'-Inosinic Acid (1:1)
• 5′-Cytidylic acid, homopolymer, complex with 5′-inosinic acid homopolymer (1:1)
• 5′-Cytidylic acid, polymers, complex with 5′-inosinic acid polymers (1:1)
• 5′-Inosinic acid homopolymer-5′-cytidylic acid homopolymer complex (1:1)
• 5′-Inosinic acid, homopolymer, complex with 5′-cytidylic acid homopolymer (1:1)
• 5′-Inosinic acid, polymers, complex with 5′-cytidylic acid polymers (1:1)
• NSC 120949
• NSC 123233
• NSC 128576
• Poly I:C
• Poly I:C Polyinosinicacid-polycytidylic acid
• Poly(C).poly(I)
• Poly(C:I)
• Poly(I)-poly(C)
• Poly(I).poly(C) complex
• Poly(cytidylic acid)-poly(inosinic acid)
• Poly(rI)-poly(rC)
• Poly(rI:rC)
• Polycytidylic-polyinosinic acid
• Polycytidysic acid
• Polyinosinate-polycytidylate complex
• Polyinosinate:polycytidylate
• Polyinosine-polycytidylic acid
• Polyinosinic acid-polycytidylic acid
• Polyinosinic acid:polycytidylic acid complex
• Polyinosinic-polycytidylic acid complex

5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)

CAS: 24939-03-5

Fórmula: C₂₁H₃₅N₇O₁₆P₂

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 703.4874

Ref: IN-DA00I4RN

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid

Pureza: ≥90%

Ref: 54-BUP06314

Polyinosinic acid-polycytidylic acid sodium salt

CAS: 24939-03-5

Ref: 7W-GC1062

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts as the most potent IFN inducer.

Fórmula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 671.4

Ref: TM-T23171

Poly(I:C) (~90%)

Produto Controlado

CAS: 24939-03-5

Applications Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
References Smith, G.A., et al.: PLoS One, 10, e0121072 (2015); Dauletbaev, N., et al.: J. Immunol., 195, 2829 (2015); Broering, R., et al.: J. Viral Hepatitis, 21, 480 (2014); Colapicchioni, V., et al.: J. Mater. Chem. B: Mater. Biol. Med., 3, 7408 (2015)

Fórmula: H₂(C₁₀H₁₁N₄O₈P)n·H₂(C₉H₁₂N₃O₈P)n

Pureza: ~90%

Cor e Forma: Neat

Peso molecular: 671.40

Ref: TR-P688075

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Fórmula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Cor e Forma: Powder

Ref: 3D-OP29952

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Fórmula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Pureza: (Hplc-Ms) Min. 95.0 Area-%

Ref: 3D-J-030005