CAS 251293-28-4

L-Valina, L-a-glutamil-L-treonil-L-prolil-L-a-aspartil-L-cisteinil-L-fenilalanil-L-triptofil-L-lisil-L-tirosil-L-cisteinil-,cíclico (5®10)-dissulfeto

Descrição:

L-Valina, L-a-glutamil-L-treonil-L-prolil-L-a-aspartil-L-cisteinil-L-fenilalanina-L-triptofano-L-lisina-L-tirosina-L-cisteinil-, cíclico (5®10)-disulfeto, identificado pelo número CAS 251293-28-4, é um peptídeo cíclico composto por múltiplos aminoácidos. Este composto apresenta uma estrutura cíclica formada por uma ligação dissulfeto entre dois resíduos de cisteína, o que contribui para sua estabilidade e propriedades únicas. A presença de vários aminoácidos, incluindo valina, glutamato, treonina, prolina, aspartato, cisteína, fenilalanina, triptofano, lisina e tirosina, sugere que pode exibir diversas atividades biológicas, potencialmente influenciando interações proteicas e funções celulares. A natureza cíclica do peptídeo pode aumentar sua resistência à degradação enzimática, tornando-o um candidato para aplicações terapêuticas. Além disso, a disposição específica dos aminoácidos pode conferir características conformacionais únicas, afetando sua solubilidade, afinidade de ligação e atividade biológica geral. Estudos adicionais seriam necessários para elucidar suas funções precisas e possíveis usos em bioquímica ou medicina.

Fórmula: C₆₄H₈₅N₁₃O₁₈S₂

Sinónimos:

• 1:PN: JP2002087982 PAGE: 2 claimed protein
• 47: PN: WO0031265 SEQID: 3 claimedprotein
• Human urotensin II
• Urotensin II (human)
• H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Disulfide bond)

Urotensin II (human)

CAS: 251293-28-4

Urotensin II is a vasoactive somatostatin-like cyclic peptide, which has long been regarded as a peptide exclusively produced by the urophysis of teleost fish. U-II has also been cloned from man. It was found to be the most potent mammalian vasoconstrictor identified so far. Furthermore, as urotensin II immunoreactivity was also found within central nervous system and endocrine tissues, it may have additional activities.

Fórmula: C₆₄H₈₅N₁₃O₁₈S₂

Pureza: ≥ 95%

Cor e Forma: White Powder

Peso molecular: 1388.59

Ref: 01-4029364

Urotensin II (114-124), human

CAS: 251293-28-4

Human Urotensin II (114-124) is an 11-amino acid peptide with vasoconstrictor properties and agonizes GPR14.

Fórmula: C₆₄H₈₅N₁₃O₁₈S₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1388.57

Ref: TM-TP1737

Urotensin II (Human)

CAS: 251293-28-4

A potent vasoconstrictor, available in the hydrochloride form with disulfide bonds between Cys5-Cys10 and as a 0.5mg vial.
Urotensin II (UT-II) is a peptide that is found in humans and other vertebrates and is involved in biological systems such as the nervous, endocrine, cardiovascular and renal.
Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function. Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.
UT-II is widely distributed throughout the body, with highest concentrations found in the cardiovascular system, particularly in the heart and blood vessels. UT-II has been shown to have a wide range of physiological effects in humans, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin. 
In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.

Fórmula: C₆₄H₈₅N₁₃O₁₈S₂

Pureza: Min. 95%

Peso molecular: 1,388.6 g/mol

Ref: 3D-PUT-4365-V