CAS 252964-68-4

2,4-Diidro-4-[4-[4-(4-metoxifenil)-1-piperazinil]fenil]-2-(1-metilpropil)-3H-1,2,4-triazol-3-ona

Descrição:

2,4-Diidro-4-[4-[4-(4-metoxifenil)-1-piperazinil]fenil]-2-(1-metilpropil)-3H-1,2,4-triazol-3-ona, com número CAS 252964-68-4, é um composto orgânico sintético caracterizado por sua complexa estrutura molecular, que inclui um anel de triazol, um grupo piperazina e um grupo metoxifenila. Este composto exibe propriedades típicas dos derivados de triazol, como potenciais atividades antifúngicas e antimicrobianas, devido à presença do grupo funcional triazol, conhecido por sua capacidade de interagir com alvos biológicos. O anel de piperazina contribui para seu perfil farmacológico, muitas vezes melhorando a solubilidade e a biodisponibilidade. Além disso, o grupo metoxi pode influenciar a lipofilicidade do composto e sua atividade biológica geral. A presença do grupo isopropílico modifica ainda mais suas propriedades estéricas e eletrônicas, afetando potencialmente sua interação com sistemas biológicos. No geral, a estrutura única deste composto sugere que ele pode ter aplicações em química medicinal, particularmente no desenvolvimento de agentes terapêuticos. No entanto, atividades biológicas específicas e perfis de segurança exigiriam investigação adicional por meio de estudos experimentais.

Fórmula: C₂₃H₂₉N₅O₂

InChI: InChI=1S/C23H29N5O2/c1-4-18(2)28-23(29)27(17-24-28)21-7-5-19(6-8-21)25-13-15-26(16-14-25)20-9-11-22(30-3)12-10-20/h5-12,17-18H,4,13-16H2,1-3H3

Chave InChI: InChIKey=IVIVGYTUQVJVPF-UHFFFAOYSA-N

SMILES: O=C1N(C=NN1C(CC)C)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OC)C=C4

Sinónimos:

• 2-Butan-2-yl-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• 3H-1,2,4-Triazol-3-one, 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-
• 4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

4-Methoxy Itraconazole Derivative (2-sec-Butyl-4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-2H-1,2,4-triazol-3(4H)-one)

CAS: 252964-68-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₂₃H₂₉N₅O₂

Cor e Forma: Off-White Powder

Peso molecular: 407.23213

Ref: 45-1A06380

2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

CAS: 252964-68-4

Fórmula: C₂₃H₂₉N₅O₂

Cor e Forma: Solid

Peso molecular: 407.5087

Ref: IN-DA00BBXR

Itraconazole EP Impurity A

CAS: 252964-68-4

Fórmula: C₂₃H₂₉N₅O₂

Cor e Forma: Pale Pink Solid

Peso molecular: 407.52

Ref: 4Z-I-0319

4-[4-[4-(4-Methoxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Produto Controlado

CAS: 252964-68-4

Fórmula: C₂₃H₂₉N₅O₂

Cor e Forma: Neat

Peso molecular: 407.51

Ref: 86-MM0258.02

Itraconazole EP Impurity A

CAS: 252964-68-4

Fórmula: C₂₃H₂₉N₅O₂

Peso molecular: 407.52

Ref: ST-EA-CP-I3001

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one

CAS: 252964-68-4

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (ITZ) is an antifungal drug that inhibits the synthesis of ergosterol. It is used in the treatment of systemic fungal infections such as candidiasis and cryptococcosis. ITZ is a metabolite of itraconazole and fluconazole. The presence of impurities in ITZ can be detected by liquid chromatography with a diode array detector or a fluorescence detector. An antiinfective drug product should be bioequivalent to the reference product and have comparable levels of impurities. Chromatograms are used to identify peaks on a graph and measure their height (area under the curve) to determine how much of each substance is present in the sample.

Fórmula: C₂₃H₂₉N₅O₂

Pureza: Min. 95%

Cor e Forma: White To Yellow Solid

Peso molecular: 407.51 g/mol

Ref: 3D-FB19470

2-(Sec-butyl)-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS: 252964-68-4

Pureza: 97%

Peso molecular: 407.5180054

Ref: 10-F727520

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one

Produto Controlado

CAS: 252964-68-4

Impurity Itraconazole EP Impurity A
Applications 2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (Itraconazole EP Impurity A) is an intermediate of Itraconazole.

Fórmula: C₂₃H₂₉N₅O₂

Cor e Forma: Beige

Peso molecular: 407.51

Ref: TR-B693320