CAS 25316-40-9

Cloridrato de doxorrubicina

Descrição:

Cloridrato de doxorrubicina é um antibiótico antraciclínico comumente utilizado na quimioterapia do câncer. É caracterizado por sua cor vermelha brilhante e é conhecido por sua potente atividade antitumoral. O composto atua intercalando o DNA, inibindo assim a síntese de ácidos nucleicos e interrompendo a replicação das células cancerosas. A doxorrubicina é solúvel em água e apresenta um perfil de solubilidade dependente do pH, o que é importante para sua formulação e administração. Seu mecanismo de ação também envolve a geração de radicais livres, contribuindo para seus efeitos citotóxicos. No entanto, o uso de doxorrubicina está associado a vários efeitos colaterais, incluindo cardiotoxicidade, que limita sua dose acumulativa. Geralmente é administrada por via intravenosa e muitas vezes é usada em combinação com outros agentes quimioterápicos para aumentar a eficácia contra várias malignidades, incluindo câncer de mama, leucemia e linfomas. Devido aos seus significativos benefícios terapêuticos e riscos potenciais, o monitoramento e gerenciamento cuidadosos são essenciais durante o tratamento.

Fórmula: C₂₇H₂₉NO₁₁·ClH

InChI: InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

Chave InChI: InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl

Sinónimos:

• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
• (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
• (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
• (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• ADM hydrochloride
• ADR
• Adriablastina CS
• Adriacin
• Adriamycin
• Adriamycin, hydrochloride
• Adriblastin
• Adriblastina
• Adriblastina RD
• Adrosal
• Ameisu hydrochloride
• Caelyx pegylated liposomal
• DOX HCl
• Doxolipad
• Doxorubicin, HCl
• Doxorubicin-LANS
• Doxorubicin-TEVA
• Doxourbicin HCl
• Fi 106
• Fi 6804
• Hydroxydaunorubicin hydrochloride
• Lipo-Dox
• Lipodox
• Myocet liposomal

Doxorubicin hydrochloride - Bio-X ™

CAS: 25316-40-9

Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.

Fórmula: C₂₇H₂₉NO₁₁•HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 579.98 g/mol

Ref: 3D-BD164391

Doxorubicin HCl

CAS: 25316-40-9

Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.

Fórmula: C₂₇H₂₉NO₁₁·HCl

Pureza: Min. 98 Area-%

Cor e Forma: Red Powder

Peso molecular: 579.98 g/mol

Ref: 3D-AD15377

Doxorubicin hydrochloride

CAS: 25316-40-9

Fórmula: C₂₇H₃₀ClNO₁₁

Pureza: 95.0%

Cor e Forma: Solid, Crystalline Powder or Granules or Powder

Peso molecular: 579.98

Ref: 10-F021790

Doxorubicin hydrochloride, 10 mg/ml aqueous solution

CAS: 25316-40-9

Doxorubicin hydrochloride, 10 mg/ml aqueous solution, is a chemotherapeutic agent, which is an anthracycline antibiotic derived from the bacterium *Streptomyces peucetius var. caesius*. Its mode of action involves the intercalation into DNA, disrupting the replication and transcription processes crucial for cancer cell proliferation. Additionally, it generates free radicals that cause further damage to cellular structures and inhibit topoisomerase II, thereby preventing the unwinding of DNA necessary for replication.

Fórmula: C₂₇H₂₉NO₁₁•HCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 579.98 g/mol

Ref: 3D-AD184265

Des-[(4-Amino-2,3,6-trideoxy-hexapyranosyl)oxy)-1-methyl] 2-Carboxylate Doxorubicin

Produto Controlado

CAS: 25316-40-9

Fórmula: C₂₀H₁₂O₇

Cor e Forma: Neat

Peso molecular: 364.305

Ref: TR-D558001

Epirubicin EP Impurity C

CAS: 25316-40-9

Fórmula: C₂₇H₂₉NO₁₁HCl

Peso molecular: 543.53 : 36.46

Ref: ST-EA-CP-E117003

Daunorubicin EP Impurity D

CAS: 25316-40-9

Fórmula: C₂₇H₂₉NO₁₁HCl

Peso molecular: 543.53 : 36.46

Ref: ST-EA-CP-D104004