CAS 26098-04-4

Gentamicina C1a

Descrição:

Gentamicina C1a é um antibiótico aminoglicosídeo derivado da bactéria Micromonospora purpurea. É utilizado principalmente para tratar várias infecções bacterianas, particularmente aquelas causadas por bactérias Gram-negativas. Gentamicina C1a exibe um amplo espectro de atividade antibacteriana e atua inibindo a síntese de proteínas nas bactérias, levando à morte celular. A substância é caracterizada por sua estrutura complexa, que inclui múltiplos açúcares amino e um núcleo de 2-deoxiestreptamina. Geralmente é administrado por injeção devido à sua baixa biodisponibilidade oral. Gentamicina C1a é conhecido por seu potencial nefrotóxico e ototóxico, exigindo monitoramento cuidadoso da função renal e da audição durante o tratamento. O medicamento é frequentemente utilizado em combinação com outros antibióticos para aumentar sua eficácia e reduzir o risco de desenvolvimento de resistência. Sua farmacocinética envolve rápida distribuição nos tecidos do corpo, com uma meia-vida que pode variar com base na função renal. No geral, Gentamicina C1a continua sendo uma opção crítica no arsenal contra infecções graves, particularmente em ambientes hospitalares.

Fórmula: C₁₉H₃₉N₅O₇

InChI: InChI=1/C19H39N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h8-18,24-27H,3-7,20-23H2,1-2H3

Chave InChI: InChIKey=VEGXETMJINRLTH-BOZYPMBZSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Sinónimos:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-
• Geneticin C_1a
• Gentamicin C1a
• Gentamicin C_1a
• Gentamicin C₃
• Gentamycin C_1a
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-erythro-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Gentamycin C1a
• Gentamicin C3
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-
• Gentamisin C3
• GentaMycin C1a Acetate
• O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine
• 6-O-(3-Deoxy-4-methyl-3-methylamino-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine
• Gentamicin C1a Pentaacetate Salt
• GentaMicin D Acetate
• Geneticin C1a
• Gentamicin D
• O-3-Deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptaMine Pentaacetate Salt
• 6-O-[3-Deoxy-4-methyl-3-(methylamino)-β-L-arabinopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine

D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-

CAS: 26098-04-4

Fórmula: C₁₉H₃₉N₅O₇

Pureza: %

Cor e Forma: Solid

Peso molecular: 449.5423

Ref: IN-DA002RNM

Gentamicin C1a

CAS: 26098-04-4

Fórmula: C₁₉H₃₉N₅O₇

Peso molecular: 449.55

Ref: 4Z-G-044005

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol

CAS: 26098-04-4

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol

Pureza: 98+%

Peso molecular: 449.54g/mol

Ref: 54-OR1030815

Gentamicin C1a pentaacetate salt

CAS: 26098-04-4

Fórmula: C₂₉H₅₉N₅O₁₇

Pureza: ≥ 95%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 749.8

Ref: 7W-GA4559

Gentamicin C1a

CAS: 26098-04-4

Gentamicin C1a, a major component with antibacterial activity, is the precursor to Etimicin.

Fórmula: C₁₉H₃₉N₅O₇

Cor e Forma: Solid

Peso molecular: 449.54

Ref: TM-T74669

Gentamicin C1a Pentaacetate Salt

CAS: 26098-04-4

Stability Hygroscopic
Applications Antibacterial.
References Holt, H.A., et al.: J. Antimicrob. Chemother., 34, 747 (1994), Wilschanski, M., et al.: Am. J. Respir. Crit. Care Med., 161, 860 (2000),

Fórmula: C₂₉H₅₉N₅O₁₇

Cor e Forma: Beige

Peso molecular: 749.8

Ref: TR-G360590

Gentamicin C1a Deuterated Pentaacetate (>90%)

Produto Controlado

CAS: 26098-04-4

Fórmula: C₁₉H₃₉N₅O₇·C₁₀H₂₀O₁₀

Cor e Forma: Neat

Peso molecular: 449.54+(300.26)

Ref: TR-G360592

Gentamicin C1a pentaacetate

CAS: 26098-04-4

Gentamicin C1a pentaacetate is an aminoglycoside antibiotic derivative, which is synthesized through the acetylation of the hydroxyl groups in gentamicin C1a. This compound is derived from the fermentation products of Micromonospora species, a genus of actinobacteria. Its mode of action is similar to that of standard aminoglycosides, primarily involving the binding to bacterial 30S ribosomal subunits. This binding interferes with protein synthesis by causing misreading of mRNA, ultimately leading to the inhibition of protein production and bacterial cell death.

Fórmula: C₂₉H₅₉N₅O₁₇

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 749.8 g/mol

Ref: 3D-AG16458

Gentamicin C1a

CAS: 26098-04-4

Gentamicin C1a is an aminoglycoside antibiotic, which is a secondary metabolite derived from the bacterium Micromonospora. This antibiotic functions through a mode of action that involves binding to the 30S subunit of bacterial ribosomes. This binding disrupts protein synthesis by causing misreading of the mRNA, ultimately leading to inhibition of bacterial growth and cellular death.

Fórmula: C₁₉H₃₉N₅O₇

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 449.54 g/mol

Ref: 3D-AG170748

Gentamicin C1a

CAS: 26098-04-4

Fórmula: C₁₉H₃₉N₅O₇

Peso molecular: 449.5

Ref: ST-EA-CP-G33012