CAS 26098-04-4
:Gentamicina C1a
Descrição:
Gentamicina C1a é um antibiótico aminoglicosídeo derivado da bactéria Micromonospora purpurea. É utilizado principalmente para tratar várias infecções bacterianas, particularmente aquelas causadas por bactérias Gram-negativas. Gentamicina C1a exibe um amplo espectro de atividade antibacteriana e atua inibindo a síntese de proteínas nas bactérias, levando à morte celular. A substância é caracterizada por sua estrutura complexa, que inclui múltiplos açúcares amino e um núcleo de 2-deoxiestreptamina. Geralmente é administrado por injeção devido à sua baixa biodisponibilidade oral. Gentamicina C1a é conhecido por seu potencial nefrotóxico e ototóxico, exigindo monitoramento cuidadoso da função renal e da audição durante o tratamento. O medicamento é frequentemente utilizado em combinação com outros antibióticos para aumentar sua eficácia e reduzir o risco de desenvolvimento de resistência. Sua farmacocinética envolve rápida distribuição nos tecidos do corpo, com uma meia-vida que pode variar com base na função renal. No geral, Gentamicina C1a continua sendo uma opção crítica no arsenal contra infecções graves, particularmente em ambientes hospitalares.
Fórmula:C19H39N5O7
InChI:InChI=1/C19H39N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h8-18,24-27H,3-7,20-23H2,1-2H3
Chave InChI:InChIKey=VEGXETMJINRLTH-BOZYPMBZSA-N
SMILES:O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3
Sinónimos:- <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-
- Geneticin C<sub>1a</sub>
- Gentamicin C1a
- Gentamicin C<sub>1a</sub>
- Gentamicin C<sub>3</sub>
- Gentamycin C<sub>1a</sub>
- O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-erythro-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
- Gentamycin C1a
- Gentamicin C3
- O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
- D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-
- Gentamisin C3
- GentaMycin C1a Acetate
- O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine
- 6-O-(3-Deoxy-4-methyl-3-methylamino-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine
- Gentamicin C1a Pentaacetate Salt
- GentaMicin D Acetate
- Geneticin C1a
- Gentamicin D
- O-3-Deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptaMine Pentaacetate Salt
- 6-O-[3-Deoxy-4-methyl-3-(methylamino)-β-L-arabinopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine
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Pureza (%)
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100
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0
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50
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90
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95
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100
10 produtos.
D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-
CAS:Fórmula:C19H39N5O7Pureza:95%Cor e Forma:SolidPeso molecular:449.5423(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol
CAS:(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-DiolPureza:98+%Peso molecular:449.54g/molGentamicin C1a pentaacetate salt
CAS:Fórmula:C29H59N5O17Pureza:≥ 95%Cor e Forma:White to off-white crystalline powderPeso molecular:749.8Gentamicin C1a
CAS:Gentamicin C1a, a major component with antibacterial activity, is the precursor to Etimicin.Fórmula:C19H39N5O7Cor e Forma:SolidPeso molecular:449.54Gentamicin C1a Pentaacetate Salt
CAS:Stability Hygroscopic
Applications Antibacterial.
References Holt, H.A., et al.: J. Antimicrob. Chemother., 34, 747 (1994), Wilschanski, M., et al.: Am. J. Respir. Crit. Care Med., 161, 860 (2000),Fórmula:C29H59N5O17Cor e Forma:BeigePeso molecular:749.8Gentamicin C1a Deuterated Pentaacetate (>90%)
CAS:Produto ControladoFórmula:C19H39N5O7·C10H20O10Pureza:>90%Cor e Forma:NeatPeso molecular:449.5Gentamicin C1a pentaacetate
CAS:Gentamicin C1a pentaacetate is an aminoglycoside antibiotic derivative, which is synthesized through the acetylation of the hydroxyl groups in gentamicin C1a. This compound is derived from the fermentation products of Micromonospora species, a genus of actinobacteria. Its mode of action is similar to that of standard aminoglycosides, primarily involving the binding to bacterial 30S ribosomal subunits. This binding interferes with protein synthesis by causing misreading of mRNA, ultimately leading to the inhibition of protein production and bacterial cell death.
Fórmula:C29H59N5O17Pureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:749.8 g/molGentamicin C1a
CAS:Gentamicin C1a is an aminoglycoside antibiotic, which is a secondary metabolite derived from the bacterium Micromonospora. This antibiotic functions through a mode of action that involves binding to the 30S subunit of bacterial ribosomes. This binding disrupts protein synthesis by causing misreading of the mRNA, ultimately leading to inhibition of bacterial growth and cellular death.
Fórmula:C19H39N5O7Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:449.54 g/mol
