CAS 26305-03-3

pepstatina A ~120'000 U/mg

Descrição:

A pepstatina A é um potente e seletivo inibidor de aspartil proteases, particularmente renina e pepsina, e é derivada da fermentação de certas espécies da bactéria *Streptomyces*. É caracterizada por sua estrutura única, que inclui uma espinha dorsal peptídica com uma sequência específica que permite que ela se ligue efetivamente aos sítios ativos das enzimas-alvo, inibindo assim sua atividade. A substância tem um peso molecular de aproximadamente 1.000 Da e é frequentemente usada em pesquisas bioquímicas para estudar processos proteolíticos e cinética enzimática. A pepstatina A exibe alta especificidade e afinidade por aspartil proteases, tornando-se uma ferramenta valiosa tanto na pesquisa básica quanto aplicada, incluindo estudos relacionados à digestão de proteínas e regulação. Sua eficácia é frequentemente quantificada em unidades de inibição, como "120.000 U/mg", indicando sua potência. Além disso, é importante manusear a pepstatina A com cuidado, pois pode ter efeitos biológicos, e condições adequadas de armazenamento são necessárias para manter sua estabilidade e atividade.

Fórmula: C₃₄H₆₃N₅O₉

InChI: InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1

Sinónimos:

• Pepstatin A
• pepstatin A from microbial source
• Pepstatin (microbial product)
• Isovaleryl-Val-Val-Sta-Ala-Sta-OH
• N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
• (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
• Pepstatin

Pepstatin A

CAS: 26305-03-3

Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.

Fórmula: C₃₄H₆₃N₅O₉

Pureza: > 99%

Cor e Forma: White Powder

Peso molecular: 685.9

Ref: 01-4031136

Pepstatin

CAS: 26305-03-3

Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.

Fórmula: C₃₄H₆₃N₅O₉

Pureza: 96.74% - 99.94%

Cor e Forma: Solid

Peso molecular: 685.89

Ref: TM-T3695

L-Alaninamide,N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-

CAS: 26305-03-3

Fórmula: C₃₄H₆₃N₅O₉

Pureza: 75%

Cor e Forma: Solid

Peso molecular: 685.8921

Ref: IN-DA00I50B

Pepstatin A

CAS: 26305-03-3

Pepstatin A

Fórmula: C₃₄H₆₃N₅O₉

Pureza: By hplc: 98.2% (220 nm) (Typical Value in Batch COA)

Cor e Forma: white to off white powder

Peso molecular: 685.89212g/mol

Ref: 54-BIMI2205

Pepstatin

CAS: 26305-03-3

Pepstatin

Pureza: ≥95%

Peso molecular: 685.89g/mol

Ref: 54-BUP16261

Pepstatin A

CAS: 26305-03-3

Fórmula: C₃₄H₆₃N₅O₉

Pureza: >90.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 685.90

Ref: 3B-P3041

Pepstatin A

CAS: 26305-03-3

Fórmula: C₃₄H₆₃N₅O₉

Peso molecular: 685.90

Ref: 4Z-P-470001

Pepstatin A

CAS: 26305-03-3

Fórmula: C₃₄H₆₃N₅O₉

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 685.90

Ref: 7W-GE3524

Pepstatin A (Purity Higher than 90% by HPLC)

CAS: 26305-03-3

Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A has

Fórmula: C₃₄H₆₃N₅O₉

Pureza: Higher Than 90% By Hplc)

Peso molecular: 685.89 g/mol

Ref: 3D-IPA-4397

Pepstatin A (Synthetic)

CAS: 26305-03-3

Pepstatin A is a natural product that has been synthesized for use as an inhibitor of proteolytic enzymes. It inhibits the activity of a wide range of proteases and is used in vitro to study the biochemical properties of these enzymes. Pepstatin A inhibits the activity of many important proteases, including those involved in infectious diseases, such as HIV and hepatitis C virus. Pepstatin A binds to the active site on serine proteases, blocking access by their substrates and thereby inhibiting enzyme activity. The binding site is highly conserved among different types of serine protease, with approximately 90% homology between trypsin and chymotrypsin. The inhibitory mechanism involves a specific interaction between pepstatin A's hydrophobic side chain and the catalytic triad residues His57, Asp102, and Ser195 in trypsin or His57, Asp102, and Ser188 in chymotrypsin.

Fórmula: C₃₄H₆₃N₅O₉

Pureza: Min. 95%

Peso molecular: 685.89 g/mol

Ref: 3D-IPA-3998-PI

Pepstatin A

CAS: 26305-03-3

Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.

Peso molecular: 685.89 g/mol

Ref: 3D-CRB1001649