CAS 26339-90-2

Escina Ib

Descrição:

Escina Ib, com o número CAS 26339-90-2, é uma saponina triterpenoide derivada das sementes da castanha-da-índia (Aesculus hippocastanum). É conhecida por suas potenciais propriedades terapêuticas, particularmente no tratamento da insuficiência venosa e condições relacionadas. Escina Ib exibe atividades anti-inflamatórias e antioxidantes, que contribuem para sua eficácia na promoção da saúde vascular. O composto é caracterizado por sua capacidade de aumentar a permeabilidade capilar e reduzir o edema, tornando-o benéfico no manejo do inchaço e desconforto associados a vários distúrbios circulatórios. Além disso, os compostos de escina, incluindo Escina Ib, são frequentemente estudados por seu papel na melhoria da microcirculação e na proteção contra o estresse oxidativo. Embora seja reconhecido principalmente por suas aplicações medicinais, mais pesquisas continuam a explorar sua gama completa de atividades biológicas e usos potenciais em farmacologia. Assim como muitos compostos naturais, os efeitos específicos e os mecanismos de ação podem variar, exigindo consideração cuidadosa nas aplicações clínicas.

Fórmula: C₅₅H₈₆O₂₄

InChI: InChI=1/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42-,43-,44-,47-,48-,49+,51-,52+,53+,54+,55-/m0/s1

Chave InChI: InChIKey=AXNVHPCVMSNXNP-OXPBSUTMSA-N

SMILES: C(O)[C@]12[C@](C=3[C@@](C)(C[C@H]1O)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@](CO)(C)[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](C(O)=O)O6)CC5)[H])[H])(CC(C)(C)[C@@H](OC(/C(=C\C)/C)=O)[C@@H]2OC(C)=O)[H]

Sinónimos:

• (3β,16α,21β,22α)-22-(acetyloxy)-16,24,28-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranosiduronic acid
• (3β,4β,16α,21β,22α)-22-(Acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranosiduronic acid
• Aescin B
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• Oleanane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
• beta-D-Glucopyranosiduronic acid, (3beta,16alpha,21beta(Z),22alpha)-22-(acetyloxy)-16,24,28-trihydroxy-21-((2-methyl-1-oxo-2-butenyl)oxy)olean-12-en-3-yl O-beta-D-glucopyranosyl-(1.2)-O-(beta-D-glucopyranosyl-(1.4))-
• escin Ib
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• Oleanane, β-D-glucopyranosiduronic acid deriv.
• β-D-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Aescin IB
• Escin IB(Aescin IB)
• Escin Impurity 2（Escin Ib）
• 22α-(Acetyloxy)-16α,24,28-trihydroxy-21β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]oleana-12-ene-3β-yl 4-O-[2-O-(β-D-gluco-hexopyranosyl)-β-D-gluco-hexopyranosyl]-β-D-gluco-hexopyranosiduronic acid
• 3-<2''-(β-D-glucopyranosido)-4'-(β-D-glucopyranosido)-β-D-glucuronopyranosido>-21-β-angeloyl-22-α-acetylprotoescigenin
• β-d-Glucopyranosiduronic acid, [3β,16α,21β(Z),22α]-22-(acetyloxy)-16,24,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-d-glucopyranosyl-(1→2)-O-[β-d-glucopyranosyl-(1→4)]-
• Aescin ib, 98%, from Aesculus wilsonii Rehder

Escin IB

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: 7W-GY9075

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Fórmula: C₅₅H₈₆O₂₄

Pureza: 95%~99%

Peso molecular: 1131.27

Ref: BP-BP0557

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to

Fórmula: C₅₅H₈₆O₂₄

Pureza: 99.09% - 99.81%

Cor e Forma: Solid

Peso molecular: 1131.26

Ref: TM-T5S1389

Escin IB

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: 4Z-I-083004

Escin ib

CAS: 26339-90-2

Natural glycoside

Fórmula: C₅₅H₈₆O₂₄

Pureza: ≥ 85.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 1131.26

Ref: 5G-80446

Escin Ib

CAS: 26339-90-2

Escin Ib is a natural saponin glycoside, which is derived from the seeds of Aesculus hippocastanum, commonly known as horse chestnut. Its mode of action involves inhibiting the enzyme hyaluronidase, thereby reducing capillary permeability and effectively controlling edema and inflammation. Additionally, it acts by stabilizing lysosomal membranes, further contributing to its anti-inflammatory effects.

Pureza: Min. 95%

Ref: 3D-FE145234

Escin Impurity B

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: ST-EA-CP-E104002

AESCIN IB(SH)

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Pureza: 103%

Cor e Forma: Solid

Peso molecular: 1131.2569

Ref: IN-DA00BE5S