CAS 265121-04-8

Fosaprepitanto dimeglumina

Descrição:

Fosaprepitanto dimeglumina é um composto sintético usado principalmente como antiemético na prevenção de náuseas e vômitos associados à quimioterapia. É um pró-fármaco de aprepitant, que atua como um antagonista seletivo do receptor de neuroquinina-1 (NK1), inibindo assim a ação da substância P, um neuropeptídeo envolvido no reflexo do vômito. A substância é caracterizada por sua alta solubilidade em água devido à presença do grupo dimeglumina, que melhora sua biodisponibilidade. Fosaprepitant é tipicamente administrado por via intravenosa e é conhecido por sua eficácia em combinação com outros agentes antieméticos. Sua farmacocinética inclui conversão rápida em aprepitant no corpo, com uma meia-vida relativamente longa, permitindo efeitos antieméticos sustentados. Efeitos colaterais comuns podem incluir fadiga, tontura e distúrbios gastrointestinais. Como agente terapêutico, Fosaprepitanto dimeglumina desempenha um papel crucial na melhoria da qualidade de vida dos pacientes em tratamento contra o câncer, gerenciando efetivamente as náuseas e vômitos induzidos pela quimioterapia.

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

InChI: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1

Chave InChI: InChIKey=UGJUJYSRBQWCEK-GGXTVIBHSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NN(P(=O)(O)O)C(=O)N4.[C@H]([C@@H]([C@@H](CO)O)O)([C@H](CNC)O)O

Sinónimos:

• 1-Deoxy-1-(Methylamino)-D-Glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]Phosphonate
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
• D-Glucitol, 1-deoxy-1-(methylamino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) (salt)
• Fosaprepitant di(N-methylglucamine)
• Fosaprepitant dimeglumine [USAN]
• Ivemend
• Mk-0517
• Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
• Phosphonic acid, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-, compd. with 1-deoxy-1-(methylamino)-<span class="text-smallcaps">D</span>-glucitol (1:2)
• Unii-D35Fm8T64X
• Fosaprepitant dimeglumine
• Fosapitant Dimeglumine

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fórmula: C₃₇H₅₆F₇N₆O₁₆P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1004.8337

Ref: IN-DA00BF3G

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine

Pureza: ≥95%

Peso molecular: 1004.83g/mol

Ref: 54-BUP10189

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Cor e Forma: White To Off-White Solid

Peso molecular: 614.41 2*195.22

Ref: 4Z-F-361

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₁₈D₄F₇N₄O₆P·2C₇H₁₇NO₅

Cor e Forma: White To Off-White Solid

Peso molecular: 618.44 2*195.22

Ref: 4Z-F-364

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Pureza: >95.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 1,004.84

Ref: 3B-F1355

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine (MK-0517) is a soluble prodrug of aprepitant, which prevents nausea by blocking NK1 receptors.

Fórmula: C₃₇H₅₆F₇N₆O₁₆P

Pureza: 98% - 99.03%

Cor e Forma: Solid

Peso molecular: 1004.83

Ref: TM-T1790

Fosaprepitant Impurity 10

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₇P

Cor e Forma: White To Off-White Solid

Peso molecular: 630.42

Ref: 4Z-F-3617

Fosaprepitant-d4 Dimeglumine

Produto Controlado

CAS: 265121-04-8

Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Fórmula: C₃₇H₅₂D₄F₇N₆O₁₆P

Cor e Forma: Neat

Peso molecular: 1008.86

Ref: TR-F727307

Bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol); (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

CAS: 265121-04-8

Pureza: 98.05%

Peso molecular: 1004.844

Ref: 10-F979755

Fosaprepitant Dimeglumine

Produto Controlado

CAS: 265121-04-8

Applications Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Cor e Forma: White To Off-White

Peso molecular: 1004.83

Ref: TR-F727305

1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]m ethyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate

CAS: 265121-04-8

Fosaprepitant is a drug that belongs to the class of drugs used for chemotherapy. It is a prodrug that is converted in vivo to aprepitant, its active form. Fosaprepitant acts as an antagonist of the neurokinin-1 receptor (NK-1R) and inhibits the binding of substance P, which leads to an anti-inflammatory effect. Fosaprepitant has been shown to inhibit the production of substance P in animal models, leading to a reduction in inflammation. In clinical trials, fosaprepitant has been shown to be safe and well tolerated when used with other drugs such as cisplatin and docetaxel in patients with cancer.

Fórmula: C₂₃H₂₂F₇N₄O₆P•(C₇H₁₇NO₅)₂

Pureza: Min. 95%

Cor e Forma: White To Off-White Solid

Peso molecular: 1,004.83 g/mol

Ref: 3D-FD46503

Fosaprepitant-13C,15N3 Dimeglumine

Produto Controlado

CAS: 265121-04-8

Fórmula: C₃₆CH₅₆F₇N₃N₃O₁₆P

Cor e Forma: Neat

Peso molecular: 1008.82

Ref: TR-F727308