CAS 26833-87-4

Homoharringtonina

Descrição:

Homoharringtonina, com o número CAS 26833-87-4, é um alcaloide natural derivado da espécie de planta Cephalotaxus harringtonia. É conhecido principalmente por seu papel como agente antineoplásico, particularmente no tratamento de certos tipos de leucemia, como a leucemia mieloide aguda (LMA). O composto funciona inibindo a síntese de proteínas, o que leva à supressão da proliferação de células cancerosas. Homoharringtonina exibe um mecanismo de ação único ao direcionar o processo de iniciação da tradução eucariótica, tornando-o distinto de outros agentes quimioterapêuticos. Geralmente é administrado por via intravenosa e tem sido estudado por sua eficácia em combinação com outros medicamentos de quimioterapia. A substância é caracterizada por sua complexa estrutura molecular, que inclui múltiplos centros quirais, contribuindo para sua atividade biológica. Embora mostre promessas em aplicações clínicas, seu uso pode estar associado a efeitos colaterais, incluindo mielossupressão e distúrbios gastrointestinais. Pesquisas em andamento continuam a explorar seu potencial e otimizar seu uso terapêutico em oncologia.

Fórmula: C₂₉H₃₉NO₉

InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

Chave InChI: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES: O(C([C@@](CCCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

Sinónimos:

• (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brn 5687925
• Ceflatonin
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
• Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cgx-635
• Myelostat
• Nsc 141633
• Omacetaxine mepesuccinate
• Omacetaxine mepesuccinate [USAN]
• Omapro
• O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• Synribo
• Unii-6Fg8041S5B

Omacetaxine Mepesuccinate (Homoharringtonine)

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Cor e Forma: White To Off-White Solid

Peso molecular: 545.63

Ref: 4Z-O-027001

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 545.62

Ref: 7W-GP6715

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine

Pureza: ≥98%

Peso molecular: 545.62g/mol

Ref: 54-BUP10774

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 545.63

Ref: 3B-H1775

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: 95%~99%

Peso molecular: 545.629

Ref: BP-BP0732

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.

Fórmula: C₂₉H₃₉NO₉

Pureza: 98.21% - 99.91%

Cor e Forma: Off-White Cryst

Peso molecular: 545.62

Ref: TM-T3380

Homoharringtonine

CAS: 26833-87-4

Natural alkaloid

Fórmula: C₂₉H₃₉NO₉

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 545.63

Ref: 5G-89708

Homoharringtonine

Produto Controlado

CAS: 26833-87-4

Applications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester harringtonine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977), Tipping, A., et al.: Leukemia, 16, 2349 (2002), Marin, D., et al.: Cancer, 103, 1850 (2005), Levy, V., et al.: Br. J. Cancer, 95, 253 (2006), de Lavallade, H., et al.: Blood, 2779 (2007),

Fórmula: C₂₉H₃₉NO₉

Cor e Forma: Neat

Peso molecular: 545.62

Ref: TR-H596500

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.

Fórmula: C₂₉H₃₉NO₉

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 545.62 g/mol

Ref: 3D-FH15974

Homoharringtonine - Bio-X ™

CAS: 26833-87-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₉H₃₉NO₉

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 545.62 g/mol

Ref: 3D-BH300085

Homoharringtonine

CAS: 26833-87-4

Pureza: 99%

Peso molecular: 545.629

Ref: 10-F979707