CAS 27215-14-1

Neoandrographolide

Descrição:

Neoandrographolide é um composto natural derivado da planta Andrographis paniculata, comumente conhecido por suas propriedades medicinais. Pertence à classe dos diterpenoides e é caracterizado por sua complexa estrutura bicíclica, que contribui à sua atividade biológica. Este composto exibe uma variedade de efeitos farmacológicos, incluindo propriedades anti-inflamatórias, antioxidantes e antimicrobianas. Neoandrographolide tem sido estudado por suas potenciais aplicações terapêuticas, particularmente no tratamento de várias doenças, incluindo infecções e condições inflamatórias. Seu mecanismo de ação geralmente envolve a modulação de vias de sinalização e a inibição de citocinas pró-inflamatórias. Além disso, é conhecido por possuir efeitos hepatoprotetores, tornando-o de interesse na pesquisa sobre a saúde do fígado. O composto é tipicamente extraído das folhas da planta Andrographis e pode ser analisado usando várias técnicas, como cromatografia e espectroscopia, para confirmar sua pureza e concentração. No geral, Neoandrographolide representa uma área significativa de interesse na química de produtos naturais e farmacologia devido às suas diversas atividades biológicas e potenciais benefícios à saúde.

Fórmula: C₂₆H₄₀O₈

InChI: InChI=1/C26H40O8/c1-15-5-8-19-25(2,14-33-24-22(30)21(29)20(28)18(13-27)34-24)10-4-11-26(19,3)17(15)7-6-16-9-12-32-23(16)31/h9,17-22,24,27-30H,1,4-8,10-14H2,2-3H3/t17-,18-,19-,20-,21+,22-,24-,25+,26+/m1/s1

Chave InChI: InChIKey=YGCYRQKJYWQXHG-RDNQFMDVSA-N

SMILES: C[C@]12[C@@]([C@@](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)CCC1)(CCC(=C)[C@H]2CCC=4C(=O)OCC4)[H]

Sinónimos:

• (5S,6S,10R)-17-(beta-D-glucopyranosyloxy)-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,12,15-decahydro-20:5,10-dicycloretinal
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 2(5H)-Furanone, 3-[2-[5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• 3-[2-[(4aS,5R,8aS)-5,8a-Dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-5H-furan-2-one
• 5β,9β<span class="text-smallcaps">H</span>,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• Neoandrographiside
• {(1R,4aS,8aS)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalen-1-yl}methyl beta-D-glucopyranoside
• 2(5H)-Furanone, 3-[2-[5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 5β,9βH,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• Neoandrographolide
• Neoandrographolide (Neoandrographiside)
• 3-(2-((1S,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)methyl)-decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
• Andrographolide Impurity 7
• 19-hydroxy-8(17),13-laboiadien-16,15-olide-o-βD-glucopyranoside
• ANDROGRAPHOLIDE, NEO(P)
• 3-[2-[(1R,4aβ)-5α-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethyl]-2(5H)-furanone
• D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• ANDROGRAPHOLIDE, NEO-
• ent-19-Hydroxy-8(17),13-labdadien-16,15-olide 19-O-β-D-glucopyranoside
• ANDROGRAPHOLIDE, NEO(SH)
• Neoandrographolide USP/EP/BP
• 4-[2-[(4aS,5R,8aS)-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 480.5910

Ref: IN-DA00BC02

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide

Pureza: ≥98%

Peso molecular: 480.59g/mol

Ref: 54-BUP07499

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 480.59

Ref: 7W-GC5354

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.Neoandrographolide inhibits iNOS and COX-2 expression through inhibiting p38 MAPKs activation.

Fórmula: C₂₆H₄₀O₈

Pureza: 95%~99%

Peso molecular: 480.598

Ref: BP-BP0988

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 480.60

Ref: 3B-N1127

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has hypolipidemic, cardio-protective, anti-inflammatory effects, and enhances chemo-sensitivity without major liver harm.

Fórmula: C₂₆H₄₀O₈

Pureza: 98.52% - 99.00%

Cor e Forma: Less Columnar Crystal Colorless Columnar Crystal

Peso molecular: 480.59

Ref: TM-T3884

Neoandrographolide

CAS: 27215-14-1

Natural glycoside

Fórmula: C₂₆H₄₀O₈

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 480.6

Ref: 5G-89740

Neoandrographolide

Produto Controlado

CAS: 27215-14-1

Applications Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.
References Jarukamjorn, K., et al.: J. Health Sci., 54, 370-381 (2008);

Fórmula: C₂₆H₄₀O₈

Cor e Forma: Neat

Peso molecular: 480.59

Ref: TR-N389913

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide is a diterpene compound that has been shown to have a significant cytotoxic effect on HL-60 cells. It also shows matrix effects in body formation and chemiluminescence. Neoandrographolide is extracted from the plant Andrographis paniculata, which belongs to the family Acanthaceae. This plant has been used historically as a medical herb in China and India for centuries. The extract of this plant has shown anti-inflammatory properties and can be used to treat infectious diseases such as bowel disease.

Fórmula: C₂₆H₄₀O₈

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 480.6 g/mol

Ref: 3D-MN11576

3-(2-((1R,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

CAS: 27215-14-1

Pureza: 98%

Peso molecular: 480.5979919

Ref: 10-F870427