CAS 2752-65-0

Ácido gambógico

Descrição:

Ácido gambógico, com o número CAS 2752-65-0, é um composto natural derivado da resina da árvore Garcinia hanburyi, comumente conhecida como gamboge. Este pigmento amarelado é composto principalmente por uma mistura complexa de xantonas policíclicas. Ácido gambógico exibe uma variedade de atividades biológicas, incluindo propriedades anti-inflamatórias, antioxidantes e potenciais anticancerígenas, tornando-o de interesse na pesquisa farmacêutica. É caracterizado por sua cor amarela e é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. O composto foi estudado por seus efeitos em várias linhagens celulares de câncer, mostrando promessas na inibição do crescimento tumoral. Além disso, Ácido gambógico tem sido utilizado na medicina tradicional, particularmente no sudeste asiático, por suas propriedades terapêuticas. No entanto, seu uso é acompanhado de cautela devido à potencial toxicidade em concentrações mais altas. No geral, Ácido gambógico representa uma área significativa de estudo na química de produtos naturais e suas aplicações na medicina.

Fórmula: C₃₈H₄₄O₈

InChI: InChI=1/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1

Chave InChI: InChIKey=GEZHEQNLKAOMCA-RRZNCOCZSA-N

SMILES: C(/C=C(\C(O)=O)/C)[C@@]12[C@]34C(C(=O)C=5C(O3)=C(CC=C(C)C)C6=C(C5O)C=C[C@](CCC=C(C)C)(C)O6)=C[C@@](C1=O)(C[C@]4(C(C)(C)O2)[H])[H]

Sinónimos:

• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
• (2Z)-4-[(11R,14aS)-8-hydroxy-3,3,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-7,15-dioxo-3a,4,5,7-tetrahydro-3H,11H-1,5-methanofuro[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methylbut-2-enoic acid
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 1,5-Methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-α,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, [1R-[1α,1(Z),3aβ,5α,11β,14aS*]]-
• B''-Guttiferin
• Cambogic acid
• R-Gambogic acid
• Ui1907
• beta-Guttiferin
• Gambogic acid
• Gambogic acid, 95%, a caspases activator
• 3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-7-tetrahydro-8-hydroxy-alph
• Guttic acid
• β-Guttilactone
• B"-Guttiferrin
• Gambogic acid, 97%(HPLC)
• 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid
• cambogicacid
• Beta-Guttiferrin
• R,S-Gambogic acid
• alpha-GaMbogic acid
• BETA-GUTTILACTONE
• Guttatic acid
• (z)-methyl-3-pentenyl)-
• GaMbogic aci
• GUTTATIC ACID
• 1,5-methano-1h,3h,11h-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonicacid,3a,4,5,
• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid
• GUTTIC ACID
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid
• Gambogic acid, >=98%

GAMBOGIC ACID

CAS: 2752-65-0

Fórmula: C₃₈H₄₄O₈

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 628.7512

Ref: IN-DA00BD9X

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Pureza: ≥95%

Peso molecular: 628.75g/mol

Ref: 54-BUP10107

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Pureza: 98%

Peso molecular: 628.75g/mol

Ref: 54-OR1023023

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition.

Fórmula: C₃₈H₄₄O₈

Pureza: 95%~99%

Peso molecular: 628.762

Ref: BP-BP0613

Gambogic acid

CAS: 2752-65-0

Fórmula: C₃₈H₄₄O₈

Pureza: ≥ 98.0%

Cor e Forma: Yellow to orange powder

Peso molecular: 628.75

Ref: 7W-GL8216

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.

Fórmula: C₃₈H₄₄O₈

Pureza: 97.16% - 98.67%

Cor e Forma: Solid

Peso molecular: 628.75

Ref: TM-T6185

R,s-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Fórmula: C₃₈H₄₄O₈

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 628.76

Ref: 5G-80455

R-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Fórmula: C₃₈H₄₄O₈

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 628.76

Ref: 5G-85875

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a xanthonoid compound, which is a naturally occurring product derived from the resin of Garcinia hanburyi, a tree found in Southeast Asia. It functions primarily through its apoptotic and anti-proliferative effects on cancer cells. Mechanistically, Gambogic acid binds to transferrin receptors, leading to the disruption of cell survival pathways, inhibition of the NF-kB signaling pathway, and induction of apoptosis by activating caspases and influencing mitochondrial pathways.

Pureza: Min. 95%

Ref: 3D-FG42759