CAS 2753-30-2

Gedunina

Descrição:

Gedunina é um composto químico que ocorre naturalmente e é classificado como um limonoide, derivado principalmente das sementes da árvore de neem (Azadirachta indica). É conhecido por suas diversas atividades biológicas, incluindo propriedades antimaláricas, antifúngicas e anticancerígenas. Gedunina exibe uma estrutura molecular complexa caracterizada por múltiplos anéis e grupos funcionais, que contribuem para seus efeitos farmacológicos. O composto despertou interesse na química medicinal devido às suas potenciais aplicações terapêuticas, particularmente no desenvolvimento de novos agentes antimaláricos. Além disso, o mecanismo de ação de Gedunina envolve a inibição de certas enzimas e vias críticas para a sobrevivência de patógenos, tornando-se um assunto de pesquisa no campo da descoberta de medicamentos. Sua solubilidade e estabilidade em vários solventes podem variar, influenciando sua biodisponibilidade e eficácia. No geral, Gedunina representa uma área significativa de estudo para pesquisadores que exploram produtos naturais como fontes de compostos terapêuticos novos.

Fórmula: C₂₈H₃₄O₇

InChI: InChI=1S/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21+,22-,25-,26+,27+,28-/m1/s1

Chave InChI: InChIKey=YJXDGWUNRYLINJ-BHAPSIHVSA-N

SMILES: C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]6(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C6)[H])[H]

Sinónimos:

• Gedunin
• 16,17-Seco-24-nor-5α,13α,14β,17α-chola-1,20,22-trien-16-oic acid, 14,15β:21,23-diepoxy-7α,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone, acetate
• Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 5-(acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-
• D-Homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione, 7-(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-, (5α,7α,13α,14β,15β,17aα)-
• (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

Gedunin

CAS: 2753-30-2

Fórmula: C₂₈H₃₄O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 482.5654

Ref: IN-DA00C4IP

Gedunin

CAS: 2753-30-2

Gedunin

Pureza: ≥98%

Peso molecular: 482.57g/mol

Ref: 54-BUP07233

Gedunin

CAS: 2753-30-2

Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.

Fórmula: C₂₈H₃₄O₇

Pureza: 99.64% - 99.68%

Cor e Forma: Solid

Peso molecular: 482.57

Ref: TM-T21883

Gedunin

CAS: 2753-30-2

Oxygen-heterocyclic compound

Fórmula: C₂₈H₃₄O₇

Pureza: ≥ 90.0 % (HPLC)

Peso molecular: 482.57

Ref: 5G-82370

Gedunin

Produto Controlado

CAS: 2753-30-2

Stability Hygroscopic
Applications Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
References 1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 174505092. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 179134823. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111

Fórmula: C₂₈H₃₄O₇

Cor e Forma: Neat

Peso molecular: 482.56

Ref: TR-G303503

Gedunin

CAS: 2753-30-2

Gedunin is a pentacyclic triterpenoid compound which is primarily found in the neem tree (Azadirachta indica) and other plants in the Meliaceae family.Gedunin works by inhibiting heat shock proteins (Hsp), which are involved in protein folding and stress responses in cells. It also triggers apoptosis in cancer cells and modulates inflammatory pathways to reduce inflammation.Gedunin is used for its anticancer, antimalarial, antibacterial, antifungal, anti-inflammatory, and neuroprotective properties. It has shown promise in inducing apoptosis in cancer cells, effectively combating malaria parasites, exhibiting antimicrobial properties, reducing inflammation, and potentially benefiting neurodegenerative diseases like Parkinson's.

Fórmula: C₂₈H₃₄O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 482.57 g/mol

Ref: 3D-XG161760