CAS 27740-01-8

Escutelarina

Descrição:

Escutelarina é um glicosídeo flavonoide derivado principalmente da planta Scutellaria baicalensis, comumente conhecida como escutelária de Baikal. É caracterizado por sua estrutura química, que inclui um esqueleto de flavona ligado a um moiety de glicose. Escutelarina exibe várias atividades biológicas, incluindo efeitos antioxidantes, anti-inflamatórios e neuroprotetores, tornando-o de interesse na pesquisa farmacológica. O composto é solúvel em água e apresenta estabilidade moderada em condições padrão. Suas potenciais aplicações terapêuticas estão sendo exploradas em áreas como doenças neurodegenerativas e saúde cardiovascular. Além disso, Escutelarina tem sido estudado por sua capacidade de modular várias vias de sinalização, contribuindo para seus diversos efeitos farmacológicos. Assim como muitos compostos naturais, a eficácia e segurança de Escutelarina estão sujeitas a pesquisas em andamento, particularmente em relação à sua biodisponibilidade e mecanismos de ação em sistemas biológicos.

Fórmula: C₂₁H₁₈O₁₂

InChI: InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1

Chave InChI: InChIKey=DJSISFGPUUYILV-ZFORQUDYSA-N

SMILES: O=C1C=2C(OC(=C1)C3=CC=C(O)C=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=C(O)C2O

Sinónimos:

• 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• 7-(beta-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-<span class="text-smallcaps">D</span>-glucopyranuronoside
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-<span class="text-smallcaps">D</span>-
• Scutellarein 7-O-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-O-β-glucuronide
• Scutellarein 7-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronoside
• Scutellarin B
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-D-
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-D-glucopyranuronoside
• β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Scutellarin

Scutellarin

CAS: 27740-01-8

Scutellarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₁H₁₈O₁₂

Pureza: (HPLC) ≥98%

Cor e Forma: Powder

Peso molecular: 462.37

Ref: 11-1405S

β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl

CAS: 27740-01-8

Fórmula: C₂₁H₁₈O₁₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 462.3604

Ref: IN-DA002UML

Scutellarin

CAS: 27740-01-8

Fórmula: C₂₁H₁₈O₁₂

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: Yellow to brown powder

Peso molecular: 462.36

Ref: 7W-GC9987

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

CAS: 27740-01-8

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

Pureza: 98%

Peso molecular: 462.36g/mol

Ref: 54-OR1008029

Scutellarin

CAS: 27740-01-8

Scutellarin

Pureza: ≥95%

Peso molecular: 462.36g/mol

Ref: 54-BUP11189

Scutellarin

CAS: 27740-01-8

Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.

Fórmula: C₂₁H₁₈O₁₂

Pureza: 95%~99%

Peso molecular: 462.363

Ref: BP-BP1278

Scutellarin

CAS: 27740-01-8

Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.

Fórmula: C₂₁H₁₈O₁₂

Pureza: 97.12% - 99.75%

Cor e Forma: Solid

Peso molecular: 462.36

Ref: TM-T2789

Scutellarin

CAS: 27740-01-8

Natural glycoside

Fórmula: C₂₁H₁₈O₁₂

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 462.37

Ref: 5G-89788

Scutellarin

CAS: 27740-01-8

Applications Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
References Gao, C. et al.: Drug Metab. Dispos., 39, 2034 (2011); Chan, J.Y. et al.: Anticancer Res., 29, 3043 (2009); Wang, C.-Z. et al.: Phytomedicine, 17, 63 (2010);

Fórmula: C₂₁H₁₈O₁₂

Cor e Forma: Neat

Peso molecular: 462.36

Ref: TR-S201900

Scutellarin

CAS: 27740-01-8

Scutellarin is a bioactive flavonoid compound, which is derived primarily from the plant Scutellaria baicalensis and other species within the Scutellaria genus. As a naturally occurring phytochemical, Scutellarin exerts its effects through multiple biological pathways, including antioxidant, anti-inflammatory, and anti-apoptotic activities.

Fórmula: C₂₁H₁₈O₁₂

Pureza: Min. 95%

Cor e Forma: Yellow Powder

Peso molecular: 462.36 g/mol

Ref: 3D-MS08111