CAS 27848-84-6
:Nicergolina
Descrição:
Nicergolina é um composto sintético classificado como um derivado de ergolina, utilizado principalmente por suas propriedades neuroprotetoras e de melhoria cognitiva. É conhecido por sua capacidade de melhorar o fluxo sanguíneo cerebral e aumentar a utilização de oxigênio no cérebro, tornando-o benéfico no tratamento de distúrbios cognitivos associados ao envelhecimento e problemas vasculares. Nicergolina exibe uma estrutura complexa, apresentando um sistema de anéis bicíclicos característico das ergolinas, e geralmente é administrado na forma de seu sal mesilato. A substância é solúvel em água e apresenta lipofilicidade moderada, permitindo que atravesse a barreira hematoencefálica de forma eficaz. Seus efeitos farmacológicos são atribuídos à sua ação como antagonista alfa-adrenérgico e modulador de receptores de serotonina, que contribuem para seus efeitos vasodilatadores. Nicergolina é geralmente bem tolerado, com um perfil de efeitos colaterais que pode incluir tontura, distúrbios gastrointestinais e dor de cabeça. Devido às suas propriedades de melhoria cognitiva, foi explorado em vários contextos clínicos, particularmente no manejo da demência e outras deficiências cognitivas.
Fórmula:C24H26BrN3O3
InChI:InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
Chave InChI:InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
SMILES:O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3
Sinónimos:- (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
- (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
- (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
- 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
- 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
- 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
- 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
- Brn 4828393
- Cergodum
- Circo-Maren
- Dilasenil
- Duracebrol
- Ergobel
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
- Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
- Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergotop
- Fi 6714
- Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
- MNE
- Memoq
- Nicergolent
- Nicergolin
- Nicergolin [German]
- Nicergolina
- Nicergolina [DCIT]
- Nicergoline [USAN:INN:BAN:JAN]
- Nicergolinum
- Nicergolinum [INN-Latin]
- Nicotergoline
- Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
- Nimergoline
- Nimergoline base
- Nsc 150531
- Rp 19651
- Sermion
- Ta 079
- Unii-Jcv8365Fwn
- Vasospan
- [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
- Ver mais sinónimos
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
20 produtos.
Nicergoline
CAS:Fórmula:C24H26BrN3O3Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:484.39Nicergoline
CAS:<p>Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic 1-adrenoceptors on vascular smooth muscle. This Thermo Scientific Chemicals brand product was originally part </p>Fórmula:C24H27BrN3O3Cor e Forma:White to yellow, Powder or granular powderPeso molecular:485.40NICERGOLINE FOR SYSTEM SUITABILITY CRS
CAS:NICERGOLINE FOR SYSTEM SUITABILITY CRSFórmula:C24H26BrN3O3Cor e Forma:PowderPeso molecular:484.3855NICERGOLINE FOR PEAK IDENTIFICATION CRS
CAS:NICERGOLINE FOR PEAK IDENTIFICATION CRSFórmula:C24H26BrN3O3Cor e Forma:PowderPeso molecular:484.3855Nicergoline
CAS:Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.Fórmula:C24H26BrN3O3Pureza:98% - 99.80%Cor e Forma:SolidPeso molecular:484.39Nicergoline-13C-d3
CAS:Fórmula:C2313CH23D3BrN3O3Cor e Forma:White To Off-White SolidPeso molecular:488.40Nicergoline
CAS:Fórmula:C24H26BrN3O3Pureza:98.5 - 102.0 % (anhydrous basis)Cor e Forma:White to off-white or light-yellow powderPeso molecular:484.39Nicergoline-d3
CAS:Produto Controlado<p>Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.<br>References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)<br></p>Fórmula:C24D3H23BrN3O3Cor e Forma:NeatPeso molecular:487.404Nicergoline
CAS:Produto Controlado<p>Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.<br>References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)<br></p>Fórmula:C24H26BrN3O3Cor e Forma:White To Off-WhitePeso molecular:484.39Nicergoline - Bio-X ™
CAS:<p>Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms associated with cerebrovascular abnormalities. This drug works by inhibiting alpha-1 adrenoreceptors on vascular smooth muscles which results in peripheral vasodilation. Furthermore, this drug has been suggested to ameliorate cognitive deficits.</p>Fórmula:C24H26BrN3O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:484.39 g/molNicergoline
CAS:<p>α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant</p>Fórmula:C24H26BrN3O3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:484.4 g/mol
