CAS 284035-33-2

2-cloro-6-[(2R)-3-[[1,1-dimetil-2-(2-naftalenil)etil]amino]-2-hidroxipropoxi]benzonitrila

Descrição:

2-cloro-6-[(2R)-3-[[1,1-dimetil-2-(2-naftalenil)etil]amino]-2-hidroxipropoxi]benzonitrila, com número CAS 284035-33-2, é um composto orgânico sintético caracterizado por sua estrutura complexa, que inclui um grupo cloro, um moiety de benzonitrila e uma cadeia lateral de hidroxi-propóxi. Este composto é tipicamente classificado como um intermediário farmacêutico ou ingrediente ativo, frequentemente associado a aplicações terapêuticas específicas. Sua estrutura molecular sugere interações potenciais com alvos biológicos, particularmente no contexto da ligação a receptores ou inibição de enzimas. A presença do anel de naftaleno indica características hidrofóbicas, que podem influenciar sua solubilidade e biodisponibilidade. Além disso, a quiralidade do composto, indicada pela configuração (2R), sugere que ele pode exibir propriedades estereoseletivas em sistemas biológicos. No geral, as características deste composto, incluindo seus grupos funcionais e estereoquímica, contribuem para sua potencial eficácia e perfil de segurança na química medicinal.

Fórmula: C₂₄H₂₅ClN₂O₂

InChI: InChI=1/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1

Chave InChI: InChIKey=PZUJQWHTIRWCID-HXUWFJFHSA-N

SMILES: C(C(NC[C@H](COC1=C(C#N)C(Cl)=CC=C1)O)(C)C)C2=CC3=C(C=C2)C=CC=C3

Sinónimos:

• 2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
• 2-Chloro-6-{[(2R)-2-hydroxy-3-{[2-methyl-1-(2-naphthyl)propan-2-yl]amino}propyl]oxy}benzonitrile
• 2-chloro-6-({(2R)-3-[(1,1-dimethyl-2-naphthalen-2-ylethyl)amino]-2-hydroxypropyl}oxy)benzonitrile
• 2-chloro-6-{[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propyl]oxy}benzonitrile
• Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-
• Nps 2143
• Sb 262470
• Sb 262470A
• benzonitrile, 2-chloro-6-[[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropyl]oxy]-
• 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile
• NPS 2143 USP/EP/BP
• SB262470
• SB-262470(NPS-2143)
• NPS-2143(SB 262470A )
• 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143)
• CS-1600
• NPS-2143 (SB-262470)
• NPS 2143;SB 262470A;NPS2143;SB262470
• 2-Chloro-6-[3-[1, 1-diMethyl-2-(2-naphthyl)ethylaMino]-2(R)-hydroxypropoxy]benzonitrile
• 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2
• 2-chloro-6-[(2R)-3-[[1
• NPS-2143 base
• 1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-
• (R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
• NPS 2143 hydrochloride(SB-262470)
• NPS 2143; SB 262470A ; NPS2143
• NPS 2143, SB262470 hydrochloride
• NPS-2143;NPS 2143; SB 262470A; NPS2143
• CS-276

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile

CAS: 284035-33-2

Fórmula: C₂₄H₂₅ClN₂O₂

Pureza: 98%

Peso molecular: 408.9205

Ref: IN-DA007KOE

NPS-2143

CAS: 284035-33-2

NPS-2143

Pureza: ≥98%

Peso molecular: 408.92g/mol

Ref: 54-BUP10169

NPS-2143

CAS: 284035-33-2

NPS-2143 is a small molecule that enhances the mitochondrial membrane potential by regulating intracellular calcium levels. It also prevents the loss of energy metabolism and pathogenic mechanisms of cells. NPS-2143 is a competitive antagonist to the calcium-sensing receptor, which is responsible for sensing extracellular and cytosolic calcium levels. This drug has been shown to inhibit leukocyte recruitment and inflammation in the lungs, as well as inhibiting platelet aggregation. NPS-2143 binds to basic proteins and peptide hormones, such as angiotensin II, erythropoietin, follicle stimulating hormone (FSH), luteinizing hormone (LH), insulin, prolactin, growth hormone (GH), parathyroid hormone (PTH), thyroid stimulating hormone (TSH), somatostatin, vasopressin, calcitonin, glucagon, and secretin.

Fórmula: C₂₄H₂₅ClN₂O₂

Pureza: Min. 95%

Peso molecular: 408.92 g/mol

Ref: 3D-JLA03533

NPS-2143

CAS: 284035-33-2

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.

Fórmula: C₂₄H₂₅ClN₂O₂

Pureza: 99.56%

Cor e Forma: Solid

Peso molecular: 408.92

Ref: TM-T1730