CAS 28822-58-4

3-Isobutil-1-metilxantina

Descrição:

3-Isobutil-1-metilxantina (CAS 28822-58-4) é um derivado de xantina que exibe propriedades semelhantes à cafeína e à teobromina, atuando principalmente como um inibidor da fosfodiesterase. Este composto é caracterizado por suas características estruturais, que incluem um núcleo de xantina com grupos isobutil e metila em posições específicas, contribuindo para sua atividade biológica. É conhecido por seus efeitos estimulantes, melhorando a alerta e a função cognitiva, e frequentemente é estudado por suas potenciais aplicações terapêuticas em condições como asma e outros distúrbios respiratórios devido às suas propriedades broncodilatadoras. O composto é tipicamente solúvel em solventes orgânicos e exibe estabilidade moderada sob condições laboratoriais padrão. Seu perfil farmacológico inclui efeitos sobre os receptores de adenosina, que desempenham um papel crucial em vários processos fisiológicos. Assim como muitos derivados de xantina, também pode ter implicações na pesquisa relacionada a processos metabólicos e regulação de energia. Precauções de segurança e manuseio devem ser observadas, assim como com qualquer substância química, para mitigar potenciais riscos à saúde.

Fórmula: C₁₀H₁₄N₄O₂

InChI: InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

Chave InChI: InChIKey=APIXJSLKIYYUKG-UHFFFAOYSA-N

SMILES: C(C(C)C)N1C2=C(C(=O)N(C)C1=O)NC=N2

Sinónimos:

• 1-Methyl-3-(2-methylpropyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione
• 1-Methyl-3-isobutylxanthine
• 1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-
• 3,7-Dihydro-3-isobutyl-1-methyl-1H-purin-2,6-dion
• 3,7-dihidro-3-isobutil-1-metil-1H-purina-2,6-diona
• 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
• 3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
• 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione
• 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
• 3-Isobutyl-1-methylxanthine
• IMX
• Ibmx
• Isobutylmethylxanthine
• Methylisobutylxanthine
• Nsc 165960
• Sc 2964
• Xanthine, 3-isobutyl-1-methyl-

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the gro

Fórmula: C₁₀H₁₄N₄O₂

Cor e Forma: Solid, White

Peso molecular: 222.25

Ref: 02-J64598

1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 222.2438

Ref: IN-DA002WN3

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: ≥ 99.0%

Cor e Forma: White solid

Peso molecular: 222.24

Ref: 7W-GL2425

3-Isobutyl-1-Methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-Methylxanthine

Pureza: 98%

Peso molecular: 222.24g/mol

Ref: 54-OR1011019

IBMX

CAS: 28822-58-4

IBMX

Pureza: ≥98%

Peso molecular: 222.24g/mol

Ref: 54-BUP15795

IBMX

CAS: 28822-58-4

IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 98% - >99.99%

Cor e Forma: Off-White

Peso molecular: 222.24

Ref: TM-T1713

IBMX

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Peso molecular: 222.25

Ref: 4Z-K-031077

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Applications A nonspecific inhibitor of phosphodiesterases.
References Beavo., J.A., et al.: Mol. Pharmacol., 6, 597 (1970), Scamps, F., et al.: Eur. J. Pharmacol., 224, 119 (1993)

Fórmula: C₁₀H₁₄N₄O₂

Cor e Forma: Neat

Peso molecular: 222.24

Ref: TR-I785000

IBMX - Bio-X ™

Produto Controlado

CAS: 28822-58-4

IBMX is a competitive non-selective phosphodiesterase inhibitor that raises cAMP and activates PKA. It also inhibits TNFα and leukotriene synthesis. This chemical compound reduces inflammation and is an adenosine receptor antagonist.

IBMX is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₄N₄O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 222.24 g/mol

Ref: 3D-BI164529

3-Isobutyl-1-methylxanthine

Produto Controlado

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Fórmula: C₁₀H₁₄N₄O₂

Cor e Forma: Slightly Yellow Powder

Peso molecular: 222.24 g/mol

Ref: 3D-FI24659

3-Isobutyl-1-methylxanthine

Produto Controlado

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-Isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Fórmula: C₁₀H₁₄N₄O₂

Peso molecular: 222.24 g/mol

Ref: 3D-J-640140

IBMX

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 98%

Cor e Forma: Solid, Light yellow powder

Peso molecular: 222.248

Ref: 10-M01902