CAS 28860-95-9

Carbidopa

Descrição:

Carbidopa é um composto farmacêutico utilizado principalmente no tratamento da doença de Parkinson e seus sintomas. Funciona como um inibidor da dopa descarboxilase, que impede a conversão de levodopa em dopamina nos tecidos periféricos, aumentando assim a disponibilidade de levodopa para o cérebro, onde pode ser convertida em dopamina. Esse mecanismo melhora os efeitos terapêuticos da levodopa enquanto minimiza efeitos colaterais como náuseas e vômitos. Carbidopa é frequentemente administrado em combinação com levodopa para melhorar a eficácia do tratamento. O composto é caracterizado por sua fórmula molecular, que inclui átomos de carbono, hidrogênio, nitrogênio e oxigênio. Geralmente é administrado por via oral e é bem absorvido no trato gastrointestinal. Carbidopa tem um perfil de toxicidade relativamente baixo, mas pode causar efeitos colaterais como tontura, boca seca ou discinesia em alguns pacientes. Sua farmacocinética envolve rápida absorção e uma meia-vida relativamente curta, necessitando de múltiplas doses ao longo do dia para um efeito terapêutico ideal.

Fórmula: C₁₀H₁₄N₂O₄

InChI: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1

Chave InChI: InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N

SMILES: [C@@](CC1=CC(O)=C(O)C=C1)(C(O)=O)(NN)C

Sinónimos:

• (-)-<span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid
• (-)-<span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate
• (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid
• (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate
• (2S)-2-(Aminoazaniumyl)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
• (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
• (S)-Carbidopa
• (αS)-α-Hydrazinyl-3,4-dihydroxy-α-methylbenzenepropanoic acid
• 1-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid
• <span class="text-smallcaps">L</span>-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid
• <span class="text-smallcaps">L</span>-Carbidopa
• <span class="text-smallcaps">L</span>-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid
• <span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid
• <span class="text-smallcaps">L</span>-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid
• <span class="text-smallcaps">L</span>-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
• <span class="text-smallcaps">L</span>-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid
• <span class="text-smallcaps">L</span>-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid
• <span class="text-smallcaps">L</span>-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid
• <span class="text-smallcaps">L</span>-α-Methyldopahydrazine
• Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (S)-
• Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-
• Cabidopa
• Carbidopa
• HMD
• Hydrazino-α-methyldopa
• Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, <span class="text-smallcaps">L</span>-
• Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, L-
• L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid
• L-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid
• L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid
• L-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid
• L-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
• L-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid
• L-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid
• L-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid
• L-α-Methyldopahydrazine
• Lodosin
• Lodosyn
• Mk 486
• N-Aminomethyldopa
• α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
• α-Methyldopahydrazine
• Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αS)-
• L-alpha-Methyldopahydrazine
• 3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid
• Tocris-0455
• 1-(Mesithylene-2-sulfonyl)-3-nitro-1,2,4-triazole
• L-alpha-Methyl-alpha-hydrazino-beta-(3,4-dihydroxyphenylpropionic acid
• Carbidopum [INN-Latin]
• alpha-Hydrazino-alpha-methyl-beta-(3,4-dihydroxyphenyl)propionic acid
• CCRIS 5093
• 3-(3,4-DIHYDROXY-PHENYL)-2-HYDRAZINO-2-METHYL-PROPIONIC ACID
• (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (1:1)
• (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid
• SMR000058235
• NCGC00024596-01
• (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid
• alpha-hydrazino-3,4-dihydroxy-alpha-methyl-(S )-
• Carbidopa anhydrous
• Benzenepropanoic acid
• alpha-Methyldopahydrazine
• L-alpha-Methyl-beta-(3,4-dihydroxyphenyl)-alpha-hydrazinopropionic aci d
• alpha-HYDRAZINO-3,4-DIHYDROXY-alpha-METHYL-L-KINSON
• Hadrazino-alpha-methyldopa
• MLS000069628

Carbidopa Monohydrate

CAS: 28860-95-9, 38821-49-7

Fórmula: C₁₀H₁₄N₂O₄·H₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystaline

Peso molecular: 244.25

Ref: 3B-C2450

3,3,3-trideuterio-2-[dideuterio-(3,4-dihydroxyphenyl)methyl]-2-hydrazinylpropanoic acid

CAS: 28860-95-9

Fórmula: C₁₀H₁₄N₂O₄

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 226.2292

Ref: IN-DA00I5DW

Carbidopa

CAS: 28860-95-9

Carbidopa

Pureza: ≥98%

Peso molecular: 226.23g/mol

Ref: 54-BUP13336

(S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid

CAS: 28860-95-9

(S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid

Pureza: 97%

Peso molecular: 226.23g/mol

Ref: 54-OR1008689

Carbidopa

CAS: 28860-95-9

Fórmula: C₁₀H₁₄N₂O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 226.23

Ref: 4Z-C-212

Carbidopa

CAS: 28860-95-9

Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM).

Fórmula: C₁₀H₁₄N₂O₄

Pureza: 98.01% - ≥98%

Cor e Forma: Solid

Peso molecular: 226.23

Ref: TM-T6795

(S)-(-)-Carbidopa

Produto Controlado

CAS: 28860-95-9

Stability Unstable in Solution
Applications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);

Fórmula: C₁₀H₁₄N₂O₄

Cor e Forma: Neat

Peso molecular: 226.23

Ref: TR-C175985